Results 11 to 20 of about 14,999 (134)

Identification of differentially methylated genes in first-trimester placentas with trisomy 16

Scientific Reports, 2022
The presence of an extra chromosome in the embryo karyotype often dramatically affects the fate of pregnancy. Trisomy 16 is the most common aneuploidy in first-trimester miscarriages.
Ekaterina N. Tolmacheva, Stanislav A. Vasilyev, Tatiana V. Nikitina, Ekaterina S. Lytkina, Elena A. Sazhenova, Daria I. Zhigalina, Oksana Yu. Vasilyeva, Anton V. Markov, Victoria V. Demeneva, Liubov A. Tashireva, Anna A. Kashevarova, Igor N. Lebedev   +11 more
doaj   +2 more sources

LncRNA GATA3-AS1 promotes allergic rhinitis by regulating the miR-488-3p/NFIA axis

European Journal of Medical Research
Background The pathogenesis of allergic rhinitis (AR) is affected by a combination of genetic and environmental factors. Objectives This study aimed to investigate the potential mechanisms of long non-coding RNA GATA binding protein 3 antisense RNA 1 ...
Xin Zhang, Taotao Lu, Rui Li
doaj   +2 more sources

The lncRNA GATA3-AS1/miR-495-3p/CENPU axis predicts poor prognosis of breast cancer via the PLK1 signaling pathway. [PDF]

Aging (Albany NY), 2021
The function of centromere protein U (CENPU) gene in breast cancer has not been well understood. Therefore, we explored the expression profiles of CENPU gene in breast carcinoma to better understand the functions of this gene, as well as the relationship between CENPU expression and the prognosis of breast carcinoma patients.
Lin S, Zhao M, Lv Y, Mao G, Ding S, Peng F.   +5 more
europepmc   +3 more sources

LncRNA GATA3-AS1 Promotes Bladder Uroepithelial Cancer Progression by Stabilizing DDX5. [PDF]

J Cancer
Objective: Exploration of molecular markers is an ongoing focus in the field of bladder cancer research. Based on data from public databases, GATA3-AS1 was identified as upregulated in bladder urothelial carcinoma (BLCA); however, its exact function and regulatory mechanism in this context remain unclear.
Duan Y, Liu Z, Ma Y, Qi P, Guo Y, Zhang A.   +5 more
europepmc   +3 more sources

LncRNA GATA3-AS1-mediated miR-2116-5p interaction modulates TCF12 and contributes to podocyte dysfunction in childhood nephrotic syndrome. [PDF]

Clinics (Sao Paulo)
Childhood Nephrotic Syndrome (NS) is a common kidney disease. This study investigates the role of LncRNA GATA3-AS1 and miR-2116-5p in childhood NS and their impact on podocyte function.This study employed qRT-PCR to detect the levels of GATA3-AS1 and miR-2116-5p in serum and evaluated their diagnostic value.
Tong X, Zhao Y, Huang P.
europepmc   +3 more sources

GATA3 Deletion Associated With Juvenile Idiopathic Arthritis: Expanding the Phenotypic Spectrum of Hypoparathyroidism, Sensorineural Deafness, and Renal Dysplasia (HDR) Syndrome. [PDF]

Am J Med Genet A
ABSTRACT Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome is caused by pathogenic variants in the GATA3 gene located on chromosome 10p14. Here we present a 10‐year‐old girl with HDR syndrome who also has oligoarticular juvenile idiopathic arthritis (JIA).
Meiss LN, Karam AV, Shalen J, Tunkel DE, Yi BY, Guthrie KS, Kudalkar EM, Patrick AE, Rasmussen SA.   +8 more
europepmc   +2 more sources

Functional, Pharmacogenomic, and Immune Landscapes of Long Non-Coding RNAs in Cancer. [PDF]

Adv Sci (Weinh)
A systematic analysis of 33 cancer types reveals widespread associations between lncRNAs and cancer pathways, drug responses, immune features, and immunotherapy outcomes. The study identifies key lncRNAs linked to therapeutic response and adverse events and introduces PILNC, an interactive web portal for exploring the functional, pharmacogenomic, and ...
Wang R, Luo M, Liu Y, Yang J, Chen Y, Chen C, Ma L, Ding S, Wengler J, Zang Y, Lim B, Li W, Yang L, Lin C, Diao L, Han L.   +15 more
europepmc   +2 more sources

Disulfidptosis-associated lncRNAs predict breast cancer subtypes

Scientific Reports, 2023
Disulfidptosis is a newly discovered mode of cell death. However, its relationship with breast cancer subtypes remains unclear. In this study, we aimed to construct a disulfidptosis-associated breast cancer subtype prediction model.
Qing Xia, Qibin Yan, Zehua Wang, Qinyuan Huang, Xinying Zheng, Jinze Shen, Lihua Du, Hanbing Li, Shiwei Duan   +8 more
doaj   +1 more source

The Expression Profiles of lncRNAs Are Associated with Neoadjuvant Chemotherapy Resistance in Locally Advanced, Luminal B-Type Breast Cancer. [PDF]

Int J Mol Sci
lncRNAs are noncoding transcripts with tissue and cancer specificity. Particularly, in breast cancer, lncRNAs exhibit subtype-specific expression; they are particularly upregulated in luminal tumors. However, no gene signature-based laboratory tests have
González-Woge M, Contreras-Espinosa L, García-Gordillo JA, Aguilar-Villanueva S, Bargallo-Rocha E, Cabrera-Galeana P, Vasquez-Mata T, Cervantes-López X, Vargas-Lías DS, Montiel-Manríquez R, Bautista-Hinojosa L, Rebollar-Vega R, Castro-Hernández C, Álvarez-Gómez RM, De La Rosa-Velázquez IA, Díaz-Chávez J, Jiménez-Trejo F, Arriaga-Canon C, Herrera LA.   +18 more
europepmc   +2 more sources

Genomic Analysis of the Function of the Transcription Factor gata3 during Development of the Mammalian Inner Ear [PDF]

, 2009
We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Lawoko-Kerali, Grace, Kneebone, Adam, Niranjan, Mahesan, Cacciabue-Rivolta, Daniela, Holley, Matthew, Van Doorninck, Hikke, Milo, Marta, Rivolta, Marcelo, Johnson, Claire   +8 more
core   +3 more sources