Results 121 to 130 of about 2,723,058 (227)

Asthma: From Phenotypes to Endotypes—Beyond Type 2 Inflammation

Respirology, Volume 31, Issue 11, Page 1077-1090, November 2026.
ABSTRACT Asthma is a heterogeneous syndrome featuring variable pathophysiology, clinical presentation and treatment response. This review examines a comprehensive endotype‐phenotype framework for asthma assessment with an emphasis on characteristics beyond T2 inflammatory status alone.
Mario Fernando, Gregory G. King
wiley   +1 more source

CXCL12/ZNF503/GATA3/MMP1 axis promotes tumor progression and metastasis of triple-negative breast cancer

Breast Cancer Research
Background Triple-negative breast cancer (TNBC) is a subtype of breast cancer which has the poorest prognosis, with high recurrence and metastasis rates. ZNF503 (Zinc finger elbow-related proline domain protein 2) was a transcriptional factor involved in
Siyu Liu, Aichen Liu, Lulu Zhang, Jing Li, Xiaobin Cao, Peiqi Yu, Yu Han, Jingjing Liu   +7 more
doaj   +1 more source

Gene regulatory mechanisms guiding bifurcation of inhibitory and excitatory neuron lineages in the mouse anterior brainstem

eLife
Selector transcription factors (TFs) control choices of alternative cellular fates during development. The ventral rhombomere 1 of the embryonic mouse (Mus musculus) brainstem produces neuronal precursors that can differentiate into either inhibitory ...
Sami Kilpinen, Lassi Virtanen, Silvana Bodington Celma, Amos Bonsdorff, Heidi Heliölä, Kaia Achim, Juha Partanen   +6 more
doaj   +1 more source

GATA3 Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population.

Reports of biochemistry & molecular biology
The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified.This case-control study was performed on 86 patients with AR and 86 healthy subjects.
Afshin, Shirkani, Atena, Mansouri, Mohammad Reza, Abbaszadegan, Reza, Faridhosseini, Farahzad, Jabbari Azad, Mehran, Gholamin   +5 more
openaire   +1 more source

Primary Hepatic Neuroendocrine Neoplasms: Systematic Review and Expert Pathologist Reappraisal Using the WHO 6th Edition Framework

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Primary hepatic neuroendocrine neoplasms (PHNENs) are exceedingly rare. Published evidence often lacks adequate clinicopathological support for a primary hepatic origin and uses inconsistent historical terminology. Previous reviews have pooled well‐differentiated neuroendocrine tumours (NETs), poorly differentiated neuroendocrine carcinomas ...
Marcello Maestri, Ottavia Cicerone, Alessandro Gambella, Federica Grillo, Stefano La Rosa, Silvia Uccella, Alessandro Vanoli   +6 more
wiley   +1 more source

Prediction of response to neoadjuvant chemotherapy in patients with muscle-invasive urothelial bladder cancer: role of immune-related gene expression

Cancer Immunology, Immunotherapy
This prospective study aimed at investigating the role of immune-related gene expression (GATA3, METTL3, ERCC2, PD-L1 and IFN-γ) in the prediction of response to platinum-based neoadjuvant chemotherapy (NAC) in treatment of muscle-invasive bladder cancer
Hadeer Mahmoud, Abeer M. Abd El-Aziz, Osama Ezzat, Hany Ibrahim Kenawy, Ahmed A. Shokeir   +4 more
doaj   +1 more source

Females Display Greater Disease Severity in a Mouse Model of Vitiligo

Pigment Cell &Melanoma Research, Volume 39, Issue 6, November 2026.
We compared depigmentation in vitiligo‐prone, h3TA2 mice among males and females, and explored the effects of treatment with HSP70iQ435A plasmid DNA, delivered by biolistic administration. Mice shown from each cohort exemplify increased depigmentation among female mice and the treatment benefit of HSP70iQ435A. ABSTRACT Vitiligo is an autoimmune disease
Kaitlyn G. O'Donnell, Zhussipbek Mukhatayev, Hanin Abuzer, Rohan S. Shivde, Sriram Saravanan Shanmugavelandy, Octavio K. Bartos, Ellis Kang, Emilia R. Dellacecca, Dinesh Jaishankar, Surya Pandey, Hee Kap Kang, Ziyou Ren, I. Caroline Le Poole   +12 more
wiley   +1 more source

Gata3 Insufficiency Accelerates Recanalization of Damaged Lymphatics via Adjusting Collagen Composition

Lymphatics
The impaired repair of lymphatic vessels after tissue damage is an etiological hallmark of lymphedema. Previously, we demonstrated that lymphatic recanalization after the popliteal lymph node extirpation was delayed in Gata2 heterozygous mice.
Moyuru Hayashi, Takuya Harada, Jun Takai, Satoshi Uemura, Takashi Moriguchi, Tomomi Watanabe-Asaka, Yoshiko Kawai   +6 more
doaj   +1 more source

A missense GATA3 mutation, Thr272Ile, causes the hypoparathyroidism, deafness, and renal dysplasia syndrome.

, 2009
CONTEXT: The hypoparathyroidism, deafness, renal dysplasia (HDR) syndrome is caused by mutations in the gene encoding GATA3, which belongs to a family of dual zinc-finger transcription factors that have a role in vertebrate embryonic development ...
Thakker, Rajesh V., Grigorieva, Irina V., Gomes, T, Nesbit, Michael, Cranston, T, Gomes, Thushari, Cranston, Treena, Grigorieva, IV, Gaynor, Katherine U., Thakker, Rajesh, Gortner, L, Gaynor, KU, Nesbit, M. Andrew, Gortner, Ludwig   +13 more
core   +1 more source

GATA3 Gene Mutation [PDF]

, 2020
openaire   +1 more source