Results 101 to 110 of about 2,723,058 (227)
Association of autoimmune Addison's disease with alleles of STAT4 and GATA3 in European cohorts.
PLoS ONE, 2014 BackgroundGene variants known to contribute to Autoimmune Addison's disease (AAD) susceptibility include those at the MHC, MICA, CIITA, CTLA4, PTPN22, CYP27B1, NLRP-1 and CD274 loci. The majority of the genetic component to disease susceptibility has yet
Anna L Mitchell +35 more
doaj +1 more source
Immunology, EarlyView.This systematic review establishes disease‐specific dysregulations of human innate lymphoid cells (ILCs), demonstrating that an ILC1/ILC3 imbalance compromises mucosal barriers in inflammatory bowel disease, while activated ILC2s drive allergic airway inflammation.
Luan F. Lückmann +7 more
wiley +1 more source
TRIM28 mediates Mettl5 ubiquitination to promotes Th2 polarization
Frontiers in ImmunologyBackgroundTh2 polarization is the primary characteristic of airway allergy (AA) and many other immune disorders. Further elucidation of its mechanism is necessary.
Beiping Miao +13 more
doaj +1 more source
Genetic Susceptibility to Periodontitis
Journal of Periodontal Research, EarlyView.Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley +1 more source
Treatment‐Associated Type 2/22 Helper T‐Cell States in Dupilumab‐Treated Atopic Dermatitis
Clinical &Experimental Allergy, EarlyView.
Mai Nishimura +5 more
wiley +1 more source
Microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases
Periodontology 2000, EarlyView.Abstract Objectives To critically evaluate the current evidence on microbial and host‐derived biomarkers for the diagnosis and management of peri‐implant diseases, with emphasis on their biological relevance, potential clinical utility, and current translational limitations.
Su Sheng Quach +5 more
wiley +1 more source
Translating gut microbiome research into therapies for type 1 diabetes
Experimental Physiology, EarlyView.Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok +2 more
wiley +1 more source
The expression and functions of Gata3 are not impaired by treatment with SH-2251.
, 2013 (A), The mRNA expression of Gata3 in the SH-2251-trearted Th2 cells was determined using quantitative RT-PCR. The relative intensity (/Hprt) is shown with the standard deviation.
Soichi Tofukuji (403144) +7 more
core +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
Identification of Key Hub Genes Associated with Breast Cancer Stem Cells to Overcome Therapy Resistance [PDF]
Iranian South Medical JournalBackground: Breast cancer is one of the most common and fatal malignancies in women. The presence of cancer stem cells (CSCs), which play a crucial role in metastasis, therapeutic resistance, and disease recurrence, presents a major treatment challenge ...
Mobina Khorshidi +3 more
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