Results 91 to 100 of about 2,723,058 (227)

Gain- and Loss-of-Function Mutations in the Breast Cancer Gene GATA3 Result in Differential Drug Sensitivity

PLOS Genetics, 2016
Patterns of somatic mutations in cancer genes provide information about their functional role in tumourigenesis, and thus indicate their potential for therapeutic exploitation. Yet, the classical distinction between oncogene and tumour suppressor may not always apply.
Barbara Mair, Tomasz Konopka, Claudia Kerzendorfer, Katia Sleiman, Sejla Salic, Violeta Serra, Markus K. Muellner, Vasiliki Theodorou, Sebastian M. B. Nijman   +8 more
openaire   +5 more sources

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Epigenetic control of cellular plasticity in breast cancer progression

The FEBS Journal, EarlyView.
Cancer cells undergo cell state transitions, termed plasticity, driving cancer progression and dictating therapeutic response. We define breast cancer plasticity into four interconnected processes: (1) breast cancer stem cell fates, (2) epithelial‐to‐mesenchymal transition, (3) maintenance of luminal identity, and (4) acquisition of therapeutic ...
Ellie J. Massey, Elizabeth Podleszanski, William J. Muller   +2 more
wiley   +1 more source

Overview of 32 Th2-specific inducible genes, highlighting their functions and GATA3 dependency.

, 2013
(*) GATA3 dependency was evaluated by the recovery score (RS) [22].(**) GATA3 dependency was evaluated by gene expression ratio (Gata3/Control siRNA).“Unevaluable” means that mRNA level was too low to detect by qPCR.Unifying 24 genes identified in the ...
Hitoshi Tanaka (423113), Yutaka Suzuki (1379), Shu Horiuchi (423111), Hiroyuki Hosokawa (46662), Toshinori Nakayama (46666), Atsushi Onodera (423109), Junji Yamashita (423112), Yasumasa Ogawa (423114), Tetsuya Sasaki (423108), Yukiko Watanabe (423110)   +9 more
core   +1 more source

Differential expression of GATA3 in cancers of the breast.

, 2022
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients ...
Shahan Mamoor
core   +1 more source

NFE2L2‐mutated urothelial carcinomas frequently show concomitant myxoid and squamous features and have high PD‐L1 expression

Histopathology, EarlyView.
Aims NFE2L2 encodes the transcription factor, NRF2, which is a regulator of cellular oxidative stress responses and metabolic homeostasis. NFE2L2 alterations are implicated in multiple cancers, with significant study in thoracic oncology, with an adverse prognosis, aggressive behaviour, metabolic reprogramming and diminished responses to chemotherapy ...
Dane Wuori, Alexander Guzzetta, Melissa Y. Tjota, Peng Wang, Tatjana Antic, Jung Woo Kwon   +5 more
wiley   +1 more source

Merkel cell carcinoma: an updated guide for pathologists

Histopathology, EarlyView.
Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine carcinoma for which the differential diagnosis can include other small cell malignancies (especially metastatic small cell carcinoma) or cutaneous carcinoma. Morphologic and immunophenotypic aberrancies in MCC can increase diagnostic challenge.
Paul W. Harms
wiley   +1 more source

Abdominal versus femoral subcutaneous fat gene expression in non-obese insulin resistant individuals

Frontiers in Endocrinology
IntroductionAdipose tissue, once viewed primarily as an energy reservoir, is now recognized as an endocrine organ involved in various physiological functions, including energy balance and immune responses.
Saif Badran, Shamma Almuraikhy, Maha Alser, Khaled Naja, Najeha Anwardeen, Hanan H. Abunada, Mohamed Badie Ahmed, Mohamed Badie Ahmed, Salma Jarrar, Ghanem Aljassem, Sara Iskeirjeh, Atalla Hammouda, Suhail A. Doi, Layla Al-Mansoori, Mohamed A. Elrayess, Mohamed A. Elrayess   +15 more
doaj   +1 more source

Gata3-deficient mice develop parathyroid abnormalities due to dysregulation of the parathyroid-specific transcription factor Gcm2

, 2010
Heterozygous mutations of GATA3, which encodes a dual zinc-finger transcription factor, cause hypoparathyroidism with sensorineural deafness and renal dysplasia. Here, we have investigated the role of GATA3 in parathyroid function by challenging Gata3+/–
Stacey, Joanna M., Kurek, Dorota, Ali, A, Grigorieva, Irina V., Nancy Manley, Fairclough, R.J. (Rebecca), Hough, D.M. (David), Rebecca J. Fairclough, Grigorieva, I.V. (Irina), Fraser, WD, Kurek, D. (Dorota), Mihai, R. (Radu), Elena F. Grigorieva, Fairclough, RJ, Irina V. Grigorieva, Manley, N, Gaynor, K.U. (Katherine), Grosveld, Frank, William D. Fraser, Nesbit, M. Andrew, Mihai, Radu, Grigorieva, E.F. (Elena), Mihai, R, Tertius Hough, Rajesh V. Thakker, Ali, Asif, Katherine U. Gaynor, Joanna M. Stacey, Nesbit, M.A. (M. Andrew), Ali, A. (Asif), Wei, QZ, Brian G. Condie, Wei, Qiaozhi, Hough, Tertius, Mirczuk, S, Stechman, MJ, Stechman, Michael J., Condie, B.G. (Brian), Manley, G. (Geoffrey), Grosveld, F.G. (Frank), Asif Ali, Thakker, R.V. (Rajesh), Frank Grosveld, Condie, Brian G., Thakker, RV, Mirczuk, S. (Samantha), Stacey, JM, Gaynor, Katherine U., Wei, Q. (Qiaozhi), Grigorieva, Elena F., Nesbit, MA, M. Andrew Nesbit, Manley, Nancy, Hough, T, Stacey, J.M. (Joanna), Samantha Mirczuk, Michael J. Stechman, Thakker, Rajesh V., Qiaozhi Wei, Mirczuk, Samantha, Grigorieva, EF, Stechman, M.J. (Michael), Grigorieva, IV, Condie, BG, Dorota Kurek, Fairclough, Rebecca J., Fraser, William D., Radu Mihai, Fraser, W.D. (William), Gaynor, KU   +69 more
core   +1 more source

Cutaneous lymphomas – an update

Histopathology, EarlyView.
Primary cutaneous lymphomas and lymphoproliferative disorders are defined by integrated clinical, histopathological, immunophenotypic and genetic features as diagnostic criteria also in the 5th edition of the WHO classification of haematolymphoid tumors.
Werner Kempf, Christina Mitteldorf
wiley   +1 more source