Results 71 to 80 of about 2,723,058 (227)

Single‐Cell Profiling Links T‐Cell Accumulation and TH2/TH17 Dynamics to Eosinophilic Esophagitis (EoE) Activity in Children

Allergy, EarlyView.
Active EoE is associated with more and deeper epithelial eosinophil, mast cell, and T cell infiltration; inactive EoE resembles controls. During remission, PPI treatment leaves more tissue resident CD3+ T‐cells than TS. In active EoE, TH2 cells, IL‐10hi Tregs, and CD8+ cytotoxic T cells are enriched, while TH17 cells are relatively depleted.
Hannes Hoelz, Matthias Tobias Warkotsch, Simon Buehler, Tim Faro, Sabrina Wagner, Valeriia Andrieieva, Alisia Beckmann, Anja Jurk, Marie‐Luise Frank, Guido Piontek, Kolja Siebert, Sebastian Jarosch, Sibylle Koletzko, Helga Paula Török, Christoph Walz, Martina Rudelius, Katja Steiger, Dirk Busch, Tobias Schwerd   +18 more
wiley   +1 more source

High Expression of Three-Gene Signature Improves Prediction of Relapse-Free Survival in Estrogen Receptor-Positive and Node-Positive Breast Tumors

Biomarker Insights, 2015
The objective of the present study was to validate prognostic gene signature for estrogen receptor alpha-positive (ERα+) and lymph node (+) breast cancer for improved selection of patients for adjuvant therapy In our previous study, we identified a group
Arvind Thakkar, Hemanth Raj, Ravishankar, Bhaskaran Muthuvelan, Arun Balakrishnan, Muralidhara Padigaru   +5 more
doaj   +1 more source

GATA3 expression in triple-negative breast cancers [PDF]

, 2017
AIMS: GATA-binding protein 3 (GATA3) is a well-studied transcription factor found to be essential in the development of luminal breast epithelium and has been identified in a variety of tumour types, including breast and urothelial carcinomas, making it ...
Siddhartha Deb, Stephen B Fox, Takano, EA, Deb, S, David J Byrne, Elena A Takano, Byrne, DJ, Fox, SB   +7 more
core   +1 more source

The Origins of Allergy: An Outside‐In, Bioenergetic Hypothesis

Allergy, EarlyView.
ABSTRACT Allergic disease has risen too rapidly for inherited susceptibility to explain it, and the risk variants so far reported lie in the epithelial barrier and in type‐2 immunity. We propose a five‐layer model in which epithelial barrier and bioenergetic dysfunction may precede and promote type‐2 immune deviation rather than arise solely as its ...
Peter K. Smith, Nicholas P. West, Stanley Du Preez, Hugh A. Sampson, Peter W. Hellings, David Price, Liam O'Mahony, Carina Venter, Cezmi A. Akdis, Gil Yosipovitch   +9 more
wiley   +1 more source

Transcription factor cooperativity at a GATA3 tandem DNA sequence determines oncogenic enhancer-mediated activation

Cell Reports
Summary: The TAL1 oncogene driving T cell lymphoblastic leukemia is frequently activated through mutated cis-regulatory elements, whereby small insertions or deletions (indels) create a binding site for the transcription factor MYB.
Joana R. Costa, Yang Li, Nurkaiyisah Zaal Anuar, David O’Connor, Sunniyat Rahman, Tanya Rapoz-D’Silva, Kent T.M. Fung, Rachael Pocock, Zhaodong Li, Stephen Henderson, Lingyi Wang, Mateja E. Krulik, Sara Hyseni, Nivedita Singh, George Morrow, Yanping Guo, Daisy O.F. Gresham, Javier Herrero, Richard G. Jenner, A. Thomas Look, Dennis Kappei, Marc R. Mansour   +21 more
doaj   +1 more source

Supplementary Data and Methods from The KMT1A-GATA3-STAT3 Circuit Is a Novel Self-Renewal Signaling of Human Bladder Cancer Stem Cells

, 2017
Supplemental Materials show that KMT1A was highly expressed in BCSCs compared with either BCNSCs or normal bladder tissue, and positively regulated the self-renewal and tumorigenicity of human BCSCs via KMT1A-GATA3-STAT3 circuit.
Zhao Yang (358244), Aihua Deng (131888), Yun Zhang (131894), Luyun He (11566790), Kaisu Lin (15010253), Yong Liang (131898), Chong Li (120471), Tingyi Wen (10249)   +7 more
core   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

GATA3 amplification is associated with high grade disease in non-invasive urothelial bladder cancer but unrelated to patient prognosis

BMC Urology
Purpose We aimed to assess the impact of GATA3 binding protein (GATA3) gene copy number alterations on tumor aggressiveness, patient prognosis, and GATA3 protein expression in a large urothelial bladder cancer cohort.
Henning Plage, Adrian Frericks, Sebastian Hofbauer, Kira Furlano, Sarah Weinberger, Florian Roßner, Simon Schallenberg, Sefer Elezkurtaj, Maximilian Lennartz, Andreas Marx, Henrik Samtleben, Margit Fisch, Michael Rink, Marcin Slojewski, Krystian Kaczmarek, Thorsten Ecke, Stefan Koch, Ronald Simon, Guido Sauter, Henrik Zecha, Joachim Weischenfeldt, Tobias Klatte, Sarah Minner, David Horst, Thorsten Schlomm, Martina Kluth   +25 more
doaj   +1 more source

Functionally distinct Gata3/Chd4 complexes coordinately establish T helper 2 (Th2) cell identity

, 2013
GATA binding protein 3 (Gata3) is a GATA family transcription factor that controls differentiation of naïve CD4 T cells into T helper 2 (Th2) cells. However, it is unknown how Gata3 simultaneously activates Th2-specific genes while repressing those of ...
Tanaka, T., Tumes, D.J., Ohkubo, S., Onodera, A., Nakayama, T., Endo, Y., Kanai, A., Endoh, K., Kato, M., Suzuki, Y., Iwamura, C., Hosokawa, H., Sugano, S.   +12 more
core   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source