Results 51 to 60 of about 2,723,058 (227)

A novel frameshift variant of GATA3 (p.Ala17ProfsTer178) responsible for HDR syndrome in a Japanese family

Endocrine Journal
HDR syndrome is an autosomal dominant disorder characterized by hypoparathyroidism (H), deafness (D), and renal dysplasia (R) caused by genetic variants of the GATA3 gene.
Yutaka Hasegawa, Toshie Segawa, Ai Chida, Eriko Yoshida, Hirofumi Kinno, Hiraku Chiba, Tomoyasu Oda, Yoshihiko Takahashi, Koji Nata, Yasushi Ishigaki   +9 more
doaj   +1 more source

One‐Step Induction of Oogonia‐Like and Pro‐Spermatogonia‐Like Cells From Porcine Pluripotent Stem Cells

Advanced Science, EarlyView.
This study established a one‐step method inducing pro‐spermatogonia‐like (activating SOX17) and oogonia‐like (activating SOX17/TFAP2C) cells from porcine pgEpiSCs with a NANOS3‐tdTomato reporter. EGF activates the core PGC program and supports survival; BMP4 further induces NANOS3 and DDX4 expression; IWR1 enhances PGCLC efficiency by suppressing ...
Pengcheng He, Liang Zhong, Tianzhi Chen, Yaxuan Yan, Xinze Chen, Runbo Li, Yingjie Wang, Yadi Teng, Minglei Zhi, Meng Wang, Jinying Zhang, Fan Zhao, Dengfeng Gao, Suying Cao, Jianyong Han   +14 more
wiley   +1 more source

GATA3-ext cell sensitivity is due to on-target inhibition of G9A/GLP.

, 2016
(A-G) Dose response curves (DRC) and colony formation assay (CFA) in reduced supplement-containing medium. MCF10A control and cells expressing GATA3-ext were treated with the indicated concentrations of HMT inhibitors (A-F) or structurally related ...
Barbara Mair (3097941), Claudia Kerzendorfer (3097944), Vasiliki Theodorou (3097932), Sebastian M. B. Nijman (184825), Markus K. Muellner (256051), Tomasz Konopka (119797), Sejla Salic (3097947), Katia Sleiman (3097935), Violeta Serra (3097938)   +8 more
core   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Homocitrullinated Peptides Drive Pro‐Inflammatory T Cell Responses in a Humanized Mouse Model of Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova, Jaspreet Kaur, Gabrielle Buckley, S. M. Mansour Haeryfar, Lisa Cameron, Ewa Cairns, Lillian Barra   +6 more
wiley   +1 more source

Distribution of genotypic frequencies with respect to the GATA3 gene in female Type 2 diabetic patients and healthy individuals.

, 2018
Distribution of genotypic frequencies with respect to the GATA3 gene in female Type 2 diabetic patients and healthy individuals.
Pankaj Kumar Sarkar (5558486), Nafiul Huda (5558495), A. H. M. Nurun Nabi (5558489), Tahirah Yasmin (5130611), A. K. M. Mahbub Hasan (5558492), Md. Ismail Hosen (5558498)   +5 more
core   +1 more source

The synergistic impact of granulocytic myeloid‐derived suppressor cells and innate lymphoid cells in systemic sclerosis

Arthritis &Rheumatology, Accepted Article.
Objective Systemic sclerosis (SSc) is a chronic autoimmune disorder characterized by immune dysregulation and fibrosis, with myeloid‐derived suppressor cells (MDSCs) emerging as important regulators of immune responses. However, the role of MDSCs in SSc‐associated fibrosis and their interactions with other immune cell populations remain poorly ...
Stefanie Weber, Mario R. Angeli, Hashem Mohammadian, Hannah Labinsky, Maria Gabriella Raimondo, Richard Demmler, Yuko Ariza, Thomas Wohlfahrt, Markus Luber, Yi‐Nan Li, Jörg H.W. Distler, Tobias Bäuerle, Georg Schett, Simon Rauber, Andreas Ramming, Alina M. Ramming   +15 more
wiley   +1 more source

Association of GATA3 expression in triple-positive breast cancer with overall survival and immune cell infiltration

Scientific Reports
Breast cancer remains a leading cause of cancer-related mortality among women, with triple-positive breast cancer (TPBC) being a particularly aggressive subtype. GATA binding protein 3 (GATA3) plays a crucial role in the luminal differentiation of breast
Xiuwen Chen, Weilin Zhao, Yugang Huang, Senyuan Luo, Xianbin Tang, Qiong Yi   +5 more
doaj   +1 more source

Distribution of genotypic frequencies with respect to the GATA3 gene in male type 2 diabetic patients and healthy individuals.

, 2018
Distribution of genotypic frequencies with respect to the GATA3 gene in male type 2 diabetic patients and healthy individuals.
Pankaj Kumar Sarkar (5558486), Nafiul Huda (5558495), A. H. M. Nurun Nabi (5558489), Tahirah Yasmin (5130611), A. K. M. Mahbub Hasan (5558492), Md. Ismail Hosen (5558498)   +5 more
core   +1 more source

GATA3 mutations are non-randomly distributed and fall into functionally distinct subclasses.

, 2016
(A) Schematic of GATA3 gene and protein. TCGA mutations are coloured by class and/or type of frameshift and are mapped onto gene and protein length. Indicated are exons (E1-E6) and protein domains (TA, transactivation; ZF, zinc finger).
Barbara Mair (3097941), Claudia Kerzendorfer (3097944), Vasiliki Theodorou (3097932), Sebastian M. B. Nijman (184825), Markus K. Muellner (256051), Tomasz Konopka (119797), Sejla Salic (3097947), Katia Sleiman (3097935), Violeta Serra (3097938)   +8 more
core   +1 more source