Results 41 to 50 of about 2,723,058 (227)

Gata3 acts downstream of beta-catenin signaling to prevent ectopic metanephric kidney induction. [PDF]

PLoS Genetics, 2008
Metanephric kidney induction critically depends on mesenchymal-epithelial interactions in the caudal region of the nephric (or Wolffian) duct. Central to this process, GDNF secreted from the metanephric mesenchyme induces ureter budding by activating the
David Grote, Sami Kamel Boualia, Abdallah Souabni, Calli Merkel, Xuan Chi, Frank Costantini, Thomas Carroll, Maxime Bouchard   +7 more
doaj   +1 more source

Genome-Wide Analysis Reveals Unique Regulation of Transcription of Th2-Specific Genes by GATA3 [PDF]

The Journal of Immunology, 2011
Abstract Differentiation of naive CD4 T cells into Th2 cells is accompanied by chromatin remodeling and increased expression of a set of Th2-specific genes, including those encoding Th2 cytokines. IL-4–mediated STAT6 activation induces high levels of transcription of GATA3, a master regulator of Th2 cell differentiation, and enforced ...
Shu, Horiuchi, Atsushi, Onodera, Hiroyuki, Hosokawa, Yukiko, Watanabe, Tomoaki, Tanaka, Sumio, Sugano, Yutaka, Suzuki, Toshinori, Nakayama   +7 more
openaire   +2 more sources

DataSheet1_A GATA3 gene mutation that causes incorrect splicing and HDR syndrome: a case study and literature review.PDF

, 2023
Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an infrequent autosomal dominant genetic disorder caused by haploinsufficiency of the GATA binding protein 3 (GATA3) gene.
Yilun Tao (11429791), Wenxia Song (480265), Lin Yang (45852), Dong Han (199240), Xiaoze Li (456068), Haiwei Wang (6864011), Lihong Wang (14991), Chen Zhao (225070)   +7 more
core   +1 more source

Phase Separation of SF3B1 Serves as a Critical Post‐Transcriptional Regulator During Early Mouse Embryogenesis

Advanced Science, EarlyView.
Phase separation of SF3B1 acts as a key regulatory mechanism for dynamic alternative splicing throughout early mouse embryogenesis. Its absence triggers extensive splicing errors, which induce persistent DNA damage, defective cell cycle progression, and failed cell lineage commitment, and ultimately hinder the normal growth and development of ...
Kang Zhao, Ting‐Yu Han, Yan‐Li Cheng, Yi‐Dan Zhang, Yu‐Wei Zhang, JinJian Guo, ShaoJun Zhang, WenZe Huang, Jing Zhang, Pei‐Yu Liao, Ying Xin, ChuanChen Chu, Qing‐Yuan Sun, ZhiZhen Liu, Xiang‐Hong Ou, Jun Xie   +15 more
wiley   +1 more source

GATA3 and markers of epithelial-mesenchymal transition predict long-term benefit from tamoxifen in ER-positive breast cancer

npj Breast Cancer
GATA binding protein 3 (GATA3) is essential for normal development of the mammary gland and associated with ER-positive breast cancer. Loss of GATA3 has been associated with epithelial-mesenchymal transition (EMT) in experimental studies. We investigated
Josefine Sandström, Jens Bomanson, Gizeh Pérez-Tenorio, Carolin Jönsson, Bo Nordenskjöld, Tommy Fornander, Linda S. Lindström, Olle Stål   +7 more
doaj   +1 more source

Decreases in GATA3 dependency correlate with increases in the gene expression.

, 2013
(A), The effects of GATA3 knockdown on effector Th2 cells (1st) and fully developed Th2 cells (2nd, 3rd and 4th) were determined with qRT-PCR. The % expression (GATA3/Control siRNA) was found to be slightly increased in Il-5, Il-13, Cxcl3 and Cxcr6 in ...
Hitoshi Tanaka (423113), Yutaka Suzuki (1379), Shu Horiuchi (423111), Hiroyuki Hosokawa (46662), Toshinori Nakayama (46666), Atsushi Onodera (423109), Junji Yamashita (423112), Yasumasa Ogawa (423114), Tetsuya Sasaki (423108), Yukiko Watanabe (423110)   +9 more
core   +1 more source

DataSheet2_A GATA3 gene mutation that causes incorrect splicing and HDR syndrome: a case study and literature review.PDF

, 2023
Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an infrequent autosomal dominant genetic disorder caused by haploinsufficiency of the GATA binding protein 3 (GATA3) gene.
Yilun Tao (11429791), Wenxia Song (480265), Lin Yang (45852), Dong Han (199240), Xiaoze Li (456068), Haiwei Wang (6864011), Lihong Wang (14991), Chen Zhao (225070)   +7 more
core   +1 more source

Targeting the YAP‐BST2 Axis Overcomes Intrinsic Anti‐PD‐1 Resistance in Metastatic Gastric Cancer

Advanced Science, EarlyView.
Concurrent YAP hyperactivation and Tp53 loss in Atp4b‐expressed parietal cell lineage drives gastric cancer initiation, multi‐organ metastasis, and intrinsic resistance to anti‐PD‐1 therapy. BST2 emerges as a direct YAP‐TEAD transcriptional target that engages PIRA2 on myeloid cells to establish an immunosuppressive microenvironment.
Weihong Zhang, Shilong Wang, Meng Wang, Ruixian Yu, Jingwu Yue, Lin Shao, Hui Zhang, Mengwen Zhu, Luyang Tian, Shuting Cheng, Weimin Qin, Yang Tang, Yi Han, Wenjia Wang, Liwei An, Yan Meng, Shi Jiao, Zhaocai Zhou   +17 more
wiley   +1 more source

A transcription factor that promotes proliferation, migration, invasion, and epithelial–mesenchymal transition of ovarian cancer cells and its possible mechanisms

BioMedical Engineering OnLine, 2021
Background Ovarian cancer is one of the most common gynecological malignancies with the high morbidity and mortality. This study was aimed to explore the role of non-structure maintenance of chromosomes condensin I complex subunit H (NCAPH) in the ...
Yingying Qi, Kexin Mo, Ting Zhang
doaj   +1 more source

Table1_A GATA3 gene mutation that causes incorrect splicing and HDR syndrome: a case study and literature review.xlsx

, 2023
Hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome is an infrequent autosomal dominant genetic disorder caused by haploinsufficiency of the GATA binding protein 3 (GATA3) gene.
Yilun Tao (11429791), Wenxia Song (480265), Lin Yang (45852), Dong Han (199240), Xiaoze Li (456068), Haiwei Wang (6864011), Lihong Wang (14991), Chen Zhao (225070)   +7 more
core   +1 more source