A Novel Mutation in GATA3 Gene in a Case of Hypoparathyroidism, Deafness, and Renal Dysplasia Syndrome. [PDF]
Indian J Nephrol, 2023 A 39-year-old male was incidentally detected to have hypertension and chronic kidney disease (CKD) with left solitary functioning kidney in 2017. He has bilateral sensorineural hearing loss since adolescence. He was initially suspected to have adynamic bone disease in view of low parathyroid hormone levels and was started on teriparatide injections and
Prabhu PP +3 more
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Immunohistochemical Expression of Gata3 Gene in Patients with Breast Cancer [PDF]
Pakistan Journal of Medical and Health Sciences, 2021 Breast cancer (BC) is one of the most common cancers in the world. In numerous tissues, including the breast, GATA3 plays an important role in stimulating proliferation and differentiation. The main aims of this study is determining the types of BC (IDC and ILC) then the estimation of the role of GATA3 protein expression by immunohistochemical staining
Zeinab Hemeed Abbas +3 more
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CHD8-Dependent Chromatin Licensing Sustains Trophoblast Stem Cell Transcriptional Programs. [PDF]
Adv Sci (Weinh)In this study, Huang et al., identify chromatin remodeler CHD8 as an essential factor in TSC maintenance and placental development. CHD8‐dependent chromatin accessibility supports the occupancy of key trophoblast TFs and is coupled to KMT2A‐associated H3K4me3 deposition at TSC stem and cell cycle genes, providing a permissive chromatin environment for ...
Huang Y +16 more
europepmc +2 more sources
TGFBR3 Co‐Downregulated With GATA3 Is Associated With Methylation of the GATA3 Gene in Bladder Urothelial Carcinoma [PDF]
The Anatomical Record, 2013 ABSTRACTBladder urothelial carcinoma (BUC) accounts for ∼90% of all cases of bladder cancer. Reduced expression of TGFBR3 has been frequently observed in several types of human cancers. However, little is known about whether expression of TGFBR3 reduced in BUC and the underlying mechanisms.
Xiao-Long, Liu +6 more
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GATA3 induces the pathogenicity of Th17 cells via regulating GM-CSF expression
Frontiers in Immunology, 2023 T-bet-expressing Th17 (T-bet+RORγt+) cells are associated with the induction of pathology during experimental autoimmune encephalomyelitis (EAE) and the encephalitic nature of these Th17 cells can be explained by their ability to produce GM-CSF. However,
Matthew J. Butcher +8 more
doaj +1 more source
Reconstruction of the gene regulatory network involved in the sonic hedgehog pathway with a potential role in early development of the mouse brain. [PDF]
PLoS Computational Biology, 2014 The Sonic hedgehog (Shh) signaling pathway is crucial for pattern formation in early central nervous system development. By systematically analyzing high-throughput in situ hybridization data of E11.5 mouse brain, we found that Shh and its receptor Ptch1
Jinhua Liu +5 more
doaj +1 more source
Structure and Expression of the Human GATA3 Gene
Genomics, 1994 GATA3, a member of the GATA family that is abundantly expressed in the T-lymphocyte lineage, is thought to participate in T-cell receptor gene activation through binding to enhancers. To understand GATA3 gene regulation, we cloned the human gene and the 5' end of the mouse GATA3 gene.
M C, Labastie +5 more
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The GATA3 gene is involved in leprosy susceptibility in Brazilian patients
Infection, Genetics and Evolution, 2016 Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association.
Medeiros, Priscila +6 more
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GATA3 maintains the quiescent state of cochlear supporting cells by regulating p27kip1
Scientific Reports, 2021 Haplo-insufficiency of the GATA3 gene causes hypoparathyroidism, sensorineural hearing loss, and renal disease (HDR) syndrome. Previous studies have shown that Gata3 is required for the development of the prosensory domain and spiral ganglion neurons ...
Jiadong Xu +8 more
doaj +1 more source
A GATA3 Targeting Nucleic Acid Nanocapsule for In Vivo Gene Regulation in Asthma
ACS Nano, 2021 Allergic asthma is one of the leading chronic lung diseases of both children and adults worldwide, resulting in significant morbidity and mortality in affected individuals. Many patients have severe asthma, which is refractory to treatment, illustrating the need for the development of new therapeutics for this disease.
Tyler D. Gavitt +5 more
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