Results 11 to 20 of about 2,723,058 (227)

Decreased expression of the GATA3 gene is associated with poor prognosis in primary gastric adenocarcinoma. [PDF]

PLoS ONE, 2014
BACKGROUND: GATA binding protein 3 (GATA3) was recently proposed to function as a tumor suppressor gene in some types of human cancer. This study aims to investigate GATA3 expression and its prognostic significance in primary gastric adenocarcinoma ...
Rajiv Prasad Keshari, Wei Wang, Yu Zhang, Dan-dan Wang, Yuan-fang Li, Shu-qiang Yuan, Hai-bo Qiu, Chun-yu Huang, Yong-ming Chen, Jian-chuan Xia, Zhi-wei Zhou   +10 more
doaj   +5 more sources

Gene of the month: GATA3 [PDF]

Journal of Clinical Pathology, 2023
GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity.
Qiang, Z., Jubber, I., Lloyd, K., Cumberbatch, M., Griffin, J.   +4 more
openaire   +4 more sources

Gene expression profiling in mice with enforced Gata3 expression reveals putative targets of Gata3 in double positive thymocytes

Molecular Immunology, 2009
The zinc-finger transcription factors Gata3 and ThPOK have both been implicated in positive selection of double positive (DP) thymocytes towards the CD4 lineage. As in the absence of Gata3, expression of ThPOK is lacking, Gata3 may directly regulate ThPOK expression.
van Hamburg, Jan Piet, de Bruijn, Marjolein J W, Ribeiro de Almeida, Claudia, Dingjan, Gemma M, Hendriks, Rudi W   +4 more
openaire   +4 more sources

Genomic analysis of the function of the transcription factor gata3 during development of the mammalian inner ear. [PDF]

PLoS ONE, 2009
We have studied the function of the zinc finger transcription factor gata3 in auditory system development by analysing temporal profiles of gene expression during differentiation of conditionally immortal cell lines derived to model specific auditory ...
Marta Milo, Daniela Cacciabue-Rivolta, Adam Kneebone, Hikke Van Doorninck, Claire Johnson, Grace Lawoko-Kerali, Mahesan Niranjan, Marcelo Rivolta, Matthew Holley   +8 more
doaj   +4 more sources

FOXP3 and GATA3 Polymorphisms, Vitamin D3 and Multiple Sclerosis [PDF]

Brain Sciences, 2021
Background: Regulatory T cells (Tregs) alterations have been implicated in the pathogenesis of Multiple Sclerosis (MS). Recently, a crucial role of the X-Linked Forkhead Box P3 (FoxP3) for the development and the stability of Tregs has emerged, and FOXP3
Concetta Scazzone, Luisa Agnello, Bruna Lo Sasso, Giuseppe Salemi, Caterina Maria Gambino, Paolo Ragonese, Giuseppina Candore, Anna Maria Ciaccio, Rosaria Vincenza Giglio, Giulia Bivona, Matteo Vidali, Marcello Ciaccio   +11 more
doaj   +3 more sources

Continued expression of GATA3 is necessary for cochlear neurosensory development. [PDF]

PLoS ONE, 2013
Hair cells of the developing mammalian inner ear are progressively defined through cell fate restriction. This process culminates in the expression of the bHLH transcription factor Atoh1, which is necessary for differentiation of hair cells, but not for ...
Jeremy S Duncan, Bernd Fritzsch
doaj   +2 more sources

Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo

Intensive Care Medicine Experimental, 2021
Background Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability.
Temitayo O. Idowu, Valerie Etzrodt, Thorben Pape, Joerg Heineke, Klaus Stahl, Hermann Haller, Sascha David   +6 more
doaj   +2 more sources

Meta-analysis of human cancer microarrays reveals GATA3 is integral to the estrogen receptor alpha pathway [PDF]

Molecular Cancer, 2008
Background The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor α (ERα) pathway.
Giguère Vincent, Wilson Brian J
doaj   +2 more sources

GATA3 and a dominant regulatory gene expression profile discriminate operational tolerance in human transplantation

Clinical Immunology, 2012
Some organ-transplanted patients achieve a state of "operational tolerance" (OT) in which graft function is maintained after the complete withdrawal of immunosuppressive drugs. We used a gene panel of regulatory/inflammatory molecules (FOXP3, GATA3, IL10, TGFB1, TGFBR1/ TBX21, TNF and IFNG) to investigate the gene expression profile in peripheral blood
Pedro Manoel M, Moraes-Vieira, Maisa C S, Takenaka, Hernandez M, Silva, Sandra Maria, Monteiro, Fabiana, Agena, Francine, Lemos, David, Saitovitch, Jorge, Kalil, Verônica, Coelho   +8 more
openaire   +3 more sources

Deregulation of miR‐1245b‐5p and miR‐92a‐3p and their potential target gene, GATA3, in epithelial–mesenchymal transition pathway in breast cancer [PDF]

Cancer Reports
Background MicroRNAs (miRNAs) are small molecules that have prominent roles in tumor development and metastasis and can be used for diagnostic and therapeutic purposes.
Mahtab Yadollahi Farsani, Zeinab Amini Farsani, Shohreh Teimuri, Mohsen Kolahdouzan, Reza Eshraghi Samani, Hossein Teimori   +5 more
doaj   +3 more sources