Results 71 to 80 of about 283,536 (308)

Active mode subclock power gating

This paper presents a technique, called subclock power gating, for reducing leakage power during the active mode in low performance, energy-constrained applications.
Merrett, Geoff V., Mistry, Jatin, Biggs, John, Myers, James, Flynn, David, Al-Hashimi, Bashir   +5 more
core   +1 more source

Oxygen-Valve Formed in Cobaltite-Based Heterostructures by Ionic Liquid and Ferroelectric Dual-Gating

, 2019
Manipulation of oxygen vacancies via electric-field-controlled ionic liquid gating has been reported in many model systems within the emergent fields of oxide electronics and iontronics.
Feng Pan, Muhammad Shahrukh Saleem (6287624), Zhidong Zhang, Haijun Mao, Kun Xu, Jing Zhu, Jing Zhu (27724), Cheng Song, Muhammad Shahrukh Saleem, Wei Liu (20030), Feng Pan (257056), Cheng Song (845259), Haijun Mao (6697340), Hongrui Zhang, Youdi Gu (6287627), Hongrui Zhang (2171380), Kun Xu (116877), Jirong Sun (2169994), Jirong Sun, Xiaoyan Zhong (2552017), Wei Liu, Youdi Gu, Xiaoyan Zhong, Zhidong Zhang (270864)   +23 more
core   +1 more source

Individual T/R Module Characterisation of the TerraSAR-X Active Phased Array Antenna by Calibration Pulse Sequences with Orthogonal Codes [PDF]

, 2007
The PN Gating mode allows operating all individual T/R modules under most realistic conditions with the advantage that all modules can be characterised simultaneously.
Stangl, Martin, Markus Bachmann, Benjamin Brautigam, Schwerdt, Marco, Bachmann, Markus, Martin Stangl, Bräutigam, Benjamin, Marco Schwerdt   +7 more
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

[Gated Radiotherapy]

Igaku butsuri : Nihon Igaku Butsuri Gakkai kikanshi = Japanese journal of medical physics : an official journal of Japan Society of Medical Physics, 2001
Recent external radiotherapy requires precise localization of the target because advance in diagnostic imaging has made it possible to visualize a tiny tumor which would be curable with focused high dose irradiation. However, tumors in respiratory and bowel organs have been difficult to be given the high dose because of 1 to 3 cm movement during ...
Shirato, Hiroki, Onimaru, Rikiya, Kitamura, Kei, Watanabe, Yoshiharu, Furuya, Teruo, Fujita, Katsuhisa, Nangumo, Junya, Oda, Makoto, Oita, Masataka   +8 more
openaire   +2 more sources

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Replicase-Mediated Resistance to Cucumber Mosaic Virus Does Not Inhibit Localization and/or Trafficking of the Viral Movement Protein

Molecular Plant-Microbe Interactions, 1999
Replicase-mediated resistance to cucumber mosaic virus (CMV) affects CMV replication and restricts CMV movement. Confocal laser scanning microscopic analysis of resistant plants inoculated with either CMV or potato virus X, expressing the CMV movement ...
Tomas Canto, Peter Palukaitis
doaj   +1 more source

The loops facing the active site of prolyl oligopeptidase are crucial components in substrate gating and specificity [PDF]

, 2013
Prolyl oligopeptidase (POP) has emerged as a drug target for neurological diseases. A flexible loop structure comprising loop A (res. 189–209) and loop B (res. 577–608) at the domain interface is implicated in substrate entry to the active site.
Juliano, Luiz, Juhasz, Tuende, Módos, Károly, Szamosi, Ilona, Rea, Dean, Fueloep, Vilmos, Juliano, Luiz [UNIFESP], Szeltner, Zoltán, Juhász, Tünde, Fülöp, Vilmos, Polgár, László   +10 more
core   +1 more source