Results 61 to 70 of about 276,884 (303)
Structural biology of the TRPM4 channel: architecture, modulation, and therapeutic opportunities
Frontiers in PharmacologyTRPM4 is a Ca2+-activated, monovalent-selective cation channel that conducts Na+ and K+ while remaining essentially impermeable to Ca2+. By translating cytosolic Ca2+ elevations into membrane depolarization rather than additional Ca2+ influx, TRPM4 ...
Ingrid Araya-Durán +6 more
doaj +1 more source
Sensors, 2018 Over two-thirds of a century ago, Hodgkin and Huxley proposed the existence of voltage gated ion channels (VGICs) to carry Na+ and K+ ions across the cell membrane to create the nerve impulse, in response to depolarization of the membrane.
Alisher M. Kariev, Michael E. Green
doaj +1 more source
A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
eLife, 2023 Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor.
Priscilla S-W Yeung +2 more
doaj +1 more source
The role of cannabinoids in the neurobiology of sensory gating: a firing rate model study [PDF]
, 2006 Gating of sensory (e.g. auditory) information has been demonstrated as a reduction in the auditory-evoked potential responses recorded in the brain of both normal animals and human subjects.
Mason, Rob +9 more
core +1 more source
Versatile vector tools for efficient protein screening across multiple expression systems
FEBS Open Bio, EarlyView.A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu +5 more
wiley +1 more source
Glutathione accelerates sodium channel inactivation in excised rat axonal membrane patches [PDF]
, 1992 The effects of glutathione were studied on the gating behaviour of sodium channels in membrane patches of rat axons. Depolarizing pulses from –120 to –40 mV elicited sodium currents of up to 500 pA, indicating the simultaneous activation of up to 250 ...
Quasthoff, Stefan +3 more
core +1 more source
FEBS Open Bio, EarlyView.Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta +7 more
wiley +1 more source
Active mode subclock power gating
This paper presents a technique, called subclock power gating, for reducing leakage power during the active mode in low performance, energy-constrained applications.
Merrett, Geoff V. +5 more
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Experimental analysis of four-wave mixing in a semiconductor optical amplifier using frequency resolved optical gating [PDF]
, 2007 Four-wave mixing was performed in a multi-quantum well semiconductor optical amplifier in order to demultiplex 2 ps pulses from 80 GHz to 10 GHz. The demultiplexed pulses were measured using frequency resolved optical gating.
Barry, Liam P. +8 more
core +2 more sources