Results 61 to 70 of about 1,212,232 (342)
Aquaporins: More Than Functional Monomers in a Tetrameric Arrangement
Cells, 2018 Aquaporins (AQPs) function as tetrameric structures in which each monomer has its own permeable pathway. The combination of structural biology, molecular dynamics simulations, and experimental approaches has contributed to improve our knowledge of how ...
Marcelo Ozu +3 more
doaj +1 more source
Feto-Maternal Crosstalk in the Development of the Circadian Clock System
Frontiers in Neuroscience, 2021 The circadian (24 h) clock system adapts physiology and behavior to daily recurring changes in the environment. Compared to the extensive knowledge assembled over the last decades on the circadian system in adults, its regulation and function during ...
Mariana Astiz, Henrik Oster
doaj +1 more source
Dynamic L-type CaV1.2 channel trafficking facilitates CaV1.2 clustering and cooperative gating. [PDF]
, 2018 L-type CaV1.2 channels are key regulators of gene expression, cell excitability and muscle contraction. CaV1.2 channels organize in clusters throughout the plasma membrane.
Brust-Mascher, Ingrid +8 more
core +2 more sources
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
BiomoleculesHuman monocytes can be subdivided into phenotypically and functionally different classical, intermediate and non-classical monocytes according to the cell surface expression of CD14 and CD16.
Talia Ahrazoglu +7 more
doaj +1 more source
Effects of repetitive practice of motor tasks on somatosensory gating
Frontiers in Human Neuroscience, 2023 IntroductionDuring voluntary muscle contraction, the amplitude of the somatosensory evoked potential (SEP) is reduced by inhibiting sensory information from a peripheral nerve supplying the contracted muscle.
Mayu Akaiwa +5 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
eLife, 2023 Ca2+ release-activated Ca2+ (CRAC) channels are activated by direct physical interactions between Orai1, the channel protein, and STIM1, the endoplasmic reticulum Ca2+ sensor.
Priscilla S-W Yeung +2 more
doaj +1 more source
Improved magnetometer uses toroidal gating coil [PDF]
, 1965 Improved magnetometer employs a cylindrical, high permeability magnetic core with a toroidal gating coil and a solenoid pickup coil. Flux interaction can be reduced by electrostatically shielding the pickup coil from the gating coil.
core +1 more source
Monte Carlo study of gating and selection in potassium channels
, 2011 The study of selection and gating in potassium channels is a very important issue in modern biology. Indeed such structures are known in all types of cells in all organisms where they play many important functional roles.
A. L. Hodgkin +6 more
core +1 more source