Results 41 to 50 of about 276,884 (303)

ELISPOTs Produced by CD8 and CD4 Cells Follow Log Normal Size Distribution Permitting Objective Counting

open access: yesCells, 2015
Each positive well in ELISPOT assays contains spots of variable sizes that can range from tens of micrometers up to a millimeter in diameter. Therefore, when it comes to counting these spots the decision on setting the lower and the upper spot size ...
Alexey Y. Karulin   +7 more
doaj   +1 more source

The perception of word stress cues in Papuan Malay: A typological perspective and experimental investigation

open access: yesLaboratory Phonology, 2021
Analyses of word prosody have shown that in some Indonesian languages listeners do not make use of word stress cues. The outcomes have contributed to the conclusion that these languages do not have word stress.
Constantijn Kaland
doaj   +2 more sources

Gates of Enzymes

open access: yesChemical Reviews, 2013
This review highlights the importance of gates in enzymes. The gates control substrate access to the active site and product release, restrict solvent access to specific protein regions, and synchronize processes occurring in distinct parts of the enzyme.
Gora, Artur   +2 more
openaire   +3 more sources

Experimental challenges in ion channel research: uncovering basic principles of permeation and gating in potassium channels

open access: yesAdvances in Physics: X, 2022
Biological ion channels precisely control the flow of ions across membranes in response to a range of physical and chemical stimuli. With their ability of transporting ions in a highly selective manner and of integrating regulatory cues, they are a ...
Joao Luis Carvalho-de-Souza   +9 more
doaj   +1 more source

Demonstration of a 64-chip OCDMA system using superstructured fiber gratings and time-gating detection [PDF]

open access: yes, 2001
We investigate the benefits of using time-gating detection in an optical code-division multiple access (OCDMA) system that comprises bipolar 64-chip long superstructure fiber Bragg grating encoders and decoders. Transmission of the codes is demonstrated,
Teh, P.C.   +6 more
core   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

open access: yesFEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

The Role of Working Memory Gating in Task Switching: A Procedural Version of the Reference-Back Paradigm

open access: yesFrontiers in Psychology, 2017
Models of working memory (WM) suggest that the contents of WM are separated from perceptual input by a gate, that enables shielding information against interference when closed, and allows for rapid updating when open.
Yoav Kessler
doaj   +1 more source

Conformational changes in the catalytically inactive nucleotide-binding site of CFTR. [PDF]

open access: yes, 2013
A central step in the gating of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the association of its two cytosolic nucleotide-binding domains (NBDs) into a head-to-tail dimer, with two nucleotides bound at the ...
Mihályi Csaba   +19 more
core   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Molecular and Evolution In Silico Studies Unlock the h4-HPPD C-Terminal Tail Gating Mechanism

open access: yesBiomedicines
The enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) is involved in the catabolism of the amino acid tyrosine in organisms such as bacteria, plants, and animals.
Alfonso Trezza   +4 more
doaj   +1 more source

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