Results 101 to 110 of about 3,458 (213)

GBF1- and ACBD3-Independent Recruitment of PI4KIIIβ to Replication Sites by Rhinovirus 3A Proteins [PDF]

Journal of Virology, 2015
ABSTRACT PI4KIIIβ recruitment to Golgi membranes relies on GBF1/Arf and ACBD3. Enteroviruses such as poliovirus and coxsackievirus recruit PI4KIIIβ to their replication sites via their 3A proteins. Here, we show that human rhinovirus (HRV) 3A also recruited PI4KIIIβ to replication sites.
Dorobantu, Cristina M., Ford-Siltz, Lauren A., Sittig, Simone P., Lanke, Kjerstin H. W., Belov, George A., van Kuppeveld, Frank J. M., van der Schaar, Hilde M.   +6 more
openaire   +6 more sources

A membrane fusion protein αSNAP is a novel regulator of epithelial apical junctions. [PDF]

PLoS ONE, 2012
Tight junctions (TJs) and adherens junctions (AJs) are key determinants of the structure and permeability of epithelial barriers. Although exocytic delivery to the cell surface is crucial for junctional assembly, little is known about the mechanisms ...
Nayden G Naydenov, Bryan Brown, Gianni Harris, Michael R Dohn, Victor M Morales, Somesh Baranwal, Albert B Reynolds, Andrei I Ivanov   +7 more
doaj   +1 more source

STING-dependent recognition of cyclic di-AMP mediates type I interferon responses during Chlamydia trachomatis infection. [PDF]

, 2013
UnlabelledSTING (stimulator of interferon [IFN] genes) initiates type I IFN responses in mammalian cells through the detection of microbial nucleic acids. The membrane-bound obligate intracellular bacterium Chlamydia trachomatis induces a STING-dependent
Barker, Jeffrey R, Burdette, Dara L, Carpenter, Victoria K, Koestler, Benjamin J, Valdivia, Raphael H, Vance, Russell E, Waters, Christopher M   +6 more
core   +2 more sources

Hermansky‐Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies

IUBMB Life, Volume 77, Issue 5, May 2025.
ABSTRACT Hermansky‐Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome‐related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous albinism, bleeding tendency, and, in some cases, pulmonary fibrosis, granulomatous colitis, and ...
Francesca Tondi, Roberta Annamaria Cirsmaru, Chiara Conti, Antonia Follenzi, Paolo Gresele, Cristina Olgasi, Loredana Bury   +6 more
wiley   +1 more source

Charakterisierung des Guaninnukleotid-Austauschfaktors GBF1

, 2009
Im initiierenden Schritt der COPI-Vesikelbiogenese wird die kleine GTPase Arf1 von den beiden zur p24 Proteinfamilie gehorenden Typ I-Trans-membranproteinen p23 bzw. p24 an die Membran rekrutiert. Dort vermittelt GBF1 (Golgi-specific brefeldin A-resistance factor 1), ein sogenanntes Arf GEF (guanine nucleotide exchange factor), in Arf1 den ...
openaire   +2 more sources

SNARE VTI13 plays a unique role in endosomal trafficking pathways associated with the vacuole and is essential for cell wall organization and root hair growth in arabidopsis [PDF]

, 2014
Background and Aims: Root hairs are responsible for water and nutrient uptake from the soil and their growth is responsive to biotic and abiotic changes in their environment.
Domozych, David S., Larson, Emily R., Tierney, Mary L.   +2 more
core   +1 more source

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

Journal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.
ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang, Ben J. Hayes, Russell E. Lyons, Imtiaz A. S. Randhawa, John B. Gaughan, Nguyen X. Trach, David M. McNeill   +6 more
wiley   +1 more source

Poliovirus replication requires the N-terminus but not the catalytic Sec7 domain of ArfGEF GBF1 [PDF]

Cellular Microbiology, 2010
Viruses are intracellular parasites whose reproduction relies on factors provided by the host. The cellular protein GBF1 is critical for poliovirus replication. Here we show that the contribution of GBF1 to virus replication is different from its known activities in uninfected cells.
Belov, George A., Kovtunovych, Gennadiy, Jackson, Catherine L., Ehrenfeld, Ellie   +3 more
openaire   +2 more sources

Curcumin inhibits the replication of enterovirus 71 in vitro

Acta Pharmaceutica Sinica B, 2014
Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades, and no vaccine and effective antiviral medicine are ...
Ying Qin, Lexun Lin, Yang Chen, Shuo Wu, Xiaoning Si, Heng Wu, Xia Zhai, Yan Wang, Lei Tong, Bo Pan, Xiaoyan Zhong, Tianying Wang, Wenran Zhao, Zhaohua Zhong   +13 more
doaj   +1 more source

TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

Traffic, Volume 26, Issue 4-6, April‐June 2025.
Epithelial‐immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how the inflammatory cytokine TNF‐α modifies epithelial cell function without impacting barrier function.
Syntyche Ngalula, Cathleen R. Carlin
wiley   +1 more source