Results 81 to 90 of about 3,458 (213)
The role of GBF1 and GlcCer in UUKV infection
, 2022 During the past decades, highly pathogenic arthropod-borne viruses (arboviruses) have emerged globally, posing a threat to public health. Arboviruses not only replicate in their vertebrate hosts but feature a dual life cycle with a switch to and from their arthropod vector.
openaire +2 more sources
A Whole-Genome RNA Interference Screen Reveals a Role for Spry2 in Insulin Transcription and the Unfolded Protein Response. [PDF]
, 2017 Insulin production by the pancreatic β-cell is required for normal glucose homeostasis. While key transcription factors that bind to the insulin promoter are known, relatively little is known about the upstream regulators of insulin transcription.
Ang, Kenny +12 more
core +1 more source
Viruses, 2023 Gumboro illness is caused by the highly contagious immunosuppressive infectious bursal disease virus (IBDV), which affects the poultry industry globally.
Yesica R. Frontini-López +6 more
doaj +1 more source
bioRxiv, 2020 The components and subprocesses underlying the formation of COPI-coated vesicles at the Golgi are well understood. The coating cascade is initiated after the small GTPase Arf1 is activated by the Sec7 domain-containing guanine nucleotide exchange factor ...
Garrett Sager +5 more
semanticscholar +1 more source
SWEET1‐mediated glucose transport is crucial for energy availability in Arabidopsis
New Phytologist, Volume 249, Issue 4, Page 1816-1830, February 2026.Summary The stress‐responsive hormone abscisic acid (ABA) is known for its inhibitory effects on various physiological processes, including seed germination, often resulting in energy deprivation. Interestingly, ABA‐induced germination inhibition can be alleviated by exogenous glucose (Glc), mimicking a functional interplay between ABA and sugar ...
Xueyi Xue +3 more
wiley +1 more source
Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors [PDF]
, 2019 ARFGEF1 encodes a guanine exchange factor involved in intracellular vesicle trafficking, and is a candidate gene for childhood genetic epilepsies. To model ARFGEF1 haploinsufficiency observed in a recent Lennox Gastaut Syndrome patient, we studied a ...
Allen, Andrew S +12 more
core +1 more source
ARF1 recruits RAC1 to leading edge in neutrophil chemotaxis
Cell Communication and Signaling, 2017 Background The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils.
Yuichi Mazaki +5 more
doaj +1 more source
Dynamics of GBF1, a Brefeldin A-Sensitive Arf1 Exchange Factor at the Golgi [PDF]
Molecular Biology of the Cell, 2005 Trafficking through the Golgi apparatus requires members of the Arf family of GTPases, whose activation is regulated by guanine nucleotide exchange factors (GEFs). Once activated, Arf-GTP recruits effectors such as coat complexes and lipid-modifying enzymes to specific membrane sites, creating a domain competent for cargo concentration and transport ...
Ting-Kuang, Niu +3 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2019 The steady-state localization of Golgi-resident glycosylation enzymes in the Golgi apparatus depends on a balance between anterograde and retrograde transport.
Gaelle Boncompain +13 more
doaj +1 more source
The ArfGEF GBF-1 Is Required for ER Structure, Secretion and Endocytic Transport in C. elegans. [PDF]
PLoS ONE, 2013 Small GTPases of the Sar/Arf family are essential to generate transport containers that mediate communication between organelles of the secretory pathway.
Karin B Ackema +3 more
doaj +1 more source