Results 81 to 90 of about 1,805 (175)
Identification of GBF1 as a Cellular Factor Required for Hepatitis C Virus RNA Replication [PDF]
Journal of Virology, 2010 ABSTRACT In infected cells, hepatitis C virus (HCV) induces the formation of membrane alterations referred to as membranous webs, which are sites of RNA replication. In addition, HCV RNA replication also occurs in smaller membrane structures that are associated with the endoplasmic reticulum.
Lucie, Goueslain +9 more
openaire +2 more sources
Structural Insights into Arl1-Mediated Targeting of the Arf-GEF BIG1 to the trans-Golgi
Cell Reports, 2016 The GTPase Arf1 is the major regulator of vesicle traffic at both the cis- and trans-Golgi. Arf1 is activated at the cis-Golgi by the guanine nucleotide exchange factor (GEF) GBF1 and at the trans-Golgi by the related GEF BIG1 or its paralog, BIG2.
Antonio Galindo +5 more
doaj +1 more source
Cell Communication and Signaling, 2023 Background Lung infections caused by Streptococcus pneumonia are a global leading cause of death. The reactive oxygen species H2O2 is one of the virulence factors of Streptococcus pneumoniae. The Golgi apparatus is essential for the inflammatory response
Björn Klabunde +7 more
doaj +1 more source
Advanced Science, Volume 11, Issue 46, December 11, 2024.Airborne viral communities are influenced by weather conditions with highly prevalent Caudoviricetes in cloudy/smoggy air and Repensiviricetes in sunny/rainy air, revealing different transmission modes under various air quality conditions. They carry diverse auxiliary metabolic genes mainly for the synthesis of nucleotide sugars, dNDP/dNTP, and ...
Aihua Deng +5 more
wiley +1 more source
Arf activation at the Golgi is modulated by feed-forward stimulation of the exchange factor GBF1 [PDF]
Journal of Cell Science, 2013 ADP-ribosylation factors (Arfs) play central roles in the regulation of vesicular trafficking through the Golgi. Arfs are activated at the Golgi membrane by guanine nucleotide exchange factors (GEFs) that are recruited from cytosol. Here, we describe a novel mechanism for regulation of recruitment and activity of the ArfGEF Golgi-specific BFA ...
Douglas, Quilty +4 more
openaire +2 more sources
Charcot‐Marie‐Tooth disease in children
Annals of the Child Neurology Society, Volume 2, Issue 4, Page 256-268, December 2024.Abstract Charcot‐Marie‐Tooth (CMT) disease represents a diverse group of inherited neuropathies with a broad spectrum of symptoms. It is the most prevalent inherited neuropathy, with an estimated prevalence ranging from 9.7 to 82 cases per 100,000 individuals.
Ezgi Saylam +4 more
wiley +1 more source
Generation of Unique Poliovirus RNA Replication Organelles
mBio, 2014 Poliovirus (PV), a model for interactions of picornaviruses with host cells, replicates its genomic RNA in association with cellular membranes. The origin of PV replication membranes has not been determined.
Alexsia L. Richards +3 more
doaj +1 more source
Workflow to Select Functional Promoter DNA Baits and Screen Arrayed Gene Libraries in Yeast
Current Protocols, Volume 4, Issue 11, November 2024.Abstract The yeast one‐hybrid system (Y1H) is used extensively to identify DNA–protein interactions. The generation of large collections of open reading frames (ORFs) to be used as prey in screenings is not a bottleneck nowadays and can be carried out in‐house or offered as a service by companies. However, the straightforward use of full gene promoters
Iris Fañanás‐Pueyo +4 more
wiley +1 more source
Plants, 2016 The authors wish to make the following corrections to their paper [1].[...]
Anja Smykowski +2 more
doaj +1 more source
The unfolded protein response links ER stress to cancer-associated thrombosis
JCI Insight, 2023 Thrombosis is a common complication of advanced cancer, yet the cellular mechanisms linking malignancy to thrombosis are poorly understood. The unfolded protein response (UPR) is an ER stress response associated with advanced cancers.
Oluwatoyosi Muse +10 more
doaj +1 more source