Results 91 to 100 of about 1,805 (175)
Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity
Advanced Science, Volume 11, Issue 39, October 23, 2024.Potent small‐molecule inhibitors of Arf1, designated as DU101 and DU102, have been discovered to initiate a series of aging processes in CSCs and systemically remodeled immune microenvironment including increasing the population of tumor‐associated CD8+ CD4+ double‐positive T (DPT) cells in preclinical mouse cancer and PDX models.
Yuetong Wang +10 more
wiley +1 more source
Aging Cell, Volume 23, Issue 10, October 2024.Senescent cells produce a secretory phenotype (SASP) that acts on surrounding cells activating multiple responses. In senescent cells the SASP key factor IL‐6 also sustains and amplifies senescence interacting with the intracellular IL‐6R in anterograde traffic structures with cytosolic DNA and cGAS‐STING‐NFκB activation.
Florencia Herbstein +13 more
wiley +1 more source
The role of GBF1 in Golgi biogenesis and secretory traffic.
, 2009 The secretory pathway within a cell consists of series of membrane compartments connected by shuttling secretory vesicles containing cargo that travel from endoplasmic reticulum (ER) though ER-to-Golgi intermediate compartment (ERGIC), the Golgi ...
Szul, Tomasz
core
AG1478 Elicits a Novel Anti-Influenza Function via an EGFR-Independent, GBF1-Dependent Pathway
, 2022 Current options for preventing or treating influenza are still limited, and new treatments for influenza viral infection are urgently needed. In the present study, we serendipitously found that a small-molecule inhibitor (AG1478), previously used for ...
Cheryl Bondy +11 more
core +1 more source
Plant Direct, 2019 MYC2 is a basic helix‐loop‐helix transcription factor that acts as a repressor of blue light‐mediated photomorphogenic growth; however, it promotes lateral root formation.
Archana Kumari Srivastava +2 more
doaj +1 more source
Investigation of the role of GBF1 in the replication of positive-sense single-stranded RNA viruses
Journal of General Virology, 2018 GBF1 has emerged as a host factor required for the replication of positive-sense single-stranded RNA viruses of different families, but its mechanism of action is still unknown. GBF1 is a guanine nucleotide exchange factor for Arf family members. Recently, we identified Arf4 and Arf5 (class II Arfs) as host factors required for the replication of ...
Ferlin, Juliette +7 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2018 When eukaryotic cells divide, they must faithfully segregate not only the genetic material but also their membrane-bound organelles into each daughter cell.
Catherine L. Jackson
doaj +1 more source
Impact of Trichoderma-Based Bioformulations on Growth, Physiology, and Disease Mitigation in Sorghum [PDF]
Journal of Plant Protection and PathologyThis investigation was undertaken to assess the efficacy of biological formulations derived from endophytic Trichoderma isolates in enhancing sorghum growth and mitigating seedling diseases induced by Fusarium verticillioides (P1) and Curvularia lunata ...
Sara Arafa +3 more
doaj +1 more source
Botanic gardens are vital for delivering the Kunming‐Montreal global biodiversity framework
Biological Diversity, Volume 1, Issue 3-4, Page 120-123, December 2024.
Stephen Blackmore
wiley +1 more source
Étude sur l'interaction entre le virus de l'hépatite C et le facteur cellulaire proviral GBF1
, 2018 GBF1 has emerged as a host factor required for the replication of RNA viruses of different families. During the hepatitis C virus (HCV) life cycle, GBF1 performs a critical function at the onset of replication, but is dispensable when the replication is ...
Lebsir, Nadjet
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