Dengue Virus Genome Uncoating Requires Ubiquitination [PDF]
, 2016 The process of genome release or uncoating after viral entry is one of the least-studied steps in the flavivirus life cycle. Flaviviruses are mainly arthropod-borne viruses, including emerging and reemerging pathogens such as dengue, Zika, and West Nile ...
Byk, Laura Andrea +5 more
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Chlamydia trachomatis co-opts GBF1 and CERT to acquire host sphingomyelin for distinct roles during intracellular development. [PDF]
PLoS Pathogens, 2011 The strain designated Chlamydia trachomatis serovar that was used for experiments in this paper is Chlamydia muridarum, a species closely related to C. trachomatis (and formerly termed the Mouse Pneumonitis strain of C. trachomatis. [corrected].
Cherilyn A Elwell +7 more
doaj +1 more source
Traffic jam on the cellular secretory pathway generated by a replication protein from a plant RNA virus [PDF]
, 2014 Although positive-strand RNA [(+)RNA] viruses have a limited coding capacity, they can replicate efficiently in host cells because of their ability to use host-derived proteins, membranes, lipids, and metabolites, and to rewire cellular trafficking ...
Hyodo, Kiwamu +2 more
core +1 more source
ARF1 and GBF1 generate a PI4P-enriched environment supportive of hepatitis C virus replication. [PDF]
PLoS ONE, 2012 Cellular levels of phosphatidylinositol 4-phosphate (PI4P) have been shown to be upregulated during RNA replication of several viruses, including the HCV replicon model.
Leiliang Zhang +6 more
doaj +1 more source
Detection of in situ cleaved p115 with the cut specific antibodies in rapid protein inactivation system by tobacco etch viral protease cleavage [PDF]
, 2011 Gene perturbation methods are commonly used in the study of gene and protein function. The authors of this paper recently developed a rapid protein inactivation technique utilizing tobacco etch virus (TEV)-derived protease.
Honjo, Yasuko +2 more
core +1 more source
FEBS Letters, 2020 Membrane traffic between secretory and endosomal compartments is vesicle‐mediated and must be tightly balanced to maintain a physiological compartment size.
Kendall Walton, A. Leier, E. Sztul
semanticscholar +1 more source
ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus. [PDF]
, 2013 Small GTPases of the ADP-ribosylation factor (ARF) family, except for ARF6, mainly localize to the Golgi apparatus, where they trigger formation of coated carrier vesicles.
Kondo, Yumika +5 more
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Fine tuning Exo2, a small molecule inhibitor of secretion and retrograde trafficking pathways in mammalian cells [PDF]
, 2010 The small molecule 4-hydroxy-3-methoxybenzaldehyde (5,6,7,8-tetrahydro[1]benzothieno[2,3- d]pyrimidin-4-yl)hydrazone (Exo2) stimulates morphological changes at the mammalian Golgi and trans-Golgi network that are virtually indistinguishable from those ...
Barr +67 more
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Targeting of the Arf-GEF GBF1 to lipid droplets and Golgi membranes [PDF]
Journal of Cell Science, 2013 Lipid droplet metabolism and secretory pathway trafficking both require activation of the Arf1 small G protein. The spatio-temporal regulation of Arf1 activation is mediated by guanine nucleotide exchange factors (GEFs) of the GBF and BIG families, but the mechanisms of their localization to multiple sites within cells are poorly understood.
Bouvet, S. +3 more
openaire +3 more sources
Ricin trafficking in plant and mammalian cells [PDF]
, 2011 Ricin is a heterodimeric plant protein that is potently toxic to mammalian and many other eukaryotic cells. It is synthesized and stored in the endosperm cells of maturing Ricinus communis seeds (castor beans).
Lord, Mike, Spooner, Robert A.
core +2 more sources