Results 71 to 80 of about 1,805 (175)

Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils

Brain Circulation, 2023
CONTEXT: Circulating neutrophils and long noncoding RNAs (lncRNAs) play various roles in intracranial atherosclerotic stenosis (ICAS). OBJECTIVE: Our study aimed to detect differentially expressed (DE) lncRNAs and mRNAs in circulating neutrophils and ...
Yilin Wang, Tao Wang, Ziping Han, Rongliang Wang, Yue Hu, Zhenhong Yang, Tong Shen, Yangmin Zheng, Jichang Luo, Yan Ma, Yumin Luo, Liqun Jiao   +11 more
doaj   +1 more source

Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1. [PDF]

J Virol
ABSTRACT Enteroviruses are single-stranded, positive-sense RNA viruses causing endoplasmic reticulum (ER) stress to induce or modulate downstream signaling pathways known as the unfolded protein responses (UPR). However, viral and host factors involved in the UPR related to viral pathogenesis remain unclear.
Hirano J, Hayashi T, Kitamura K, Nishimura Y, Shimizu H, Okamoto T, Okada K, Uemura K, Yeh MT, Ono C, Taguwa S, Muramatsu M, Matsuura Y.   +12 more
europepmc   +3 more sources

BnaC04.bZIP16 can be phosphorylated and inhibited by BnaA06.SnRK2 and negatively regulates the accumulation of fatty acids in Brassica napus

The Plant Journal, Volume 124, Issue 1, October 2025.
SUMMARY Brassica napus is an important oil crop with a significant amount of fatty acid in its seeds. However, the molecular mechanisms of fatty acid synthesis and accumulation are still poorly understood. In this study, we identified a transcription factor, BnaC04.bZIP16, which belongs to the G subfamily of the bZIP family, that negatively regulates ...
Wei Hui, Shuangshuang Li, Jinhao Ding, Qianru Li, Yuhong Chen, Yanhui Wang, Xupeng Guo, Chengming Fan, Zanmin Hu   +8 more
wiley   +1 more source

Functional relationship of GBF1 with HY5 and HYH in genome-wide gene expression in Arabidopsis

, 2016
Transcriptional networks play important roles in the regulation of biological processes through coordinated activation or repression of downstream target genes.
Singh, Aparna, Ram, Hathi, Jain, Mukesh, Chattopadhyay, Sudip   +3 more
core   +1 more source

Hermansky‐Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies

IUBMB Life, Volume 77, Issue 5, May 2025.
ABSTRACT Hermansky‐Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome‐related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous albinism, bleeding tendency, and, in some cases, pulmonary fibrosis, granulomatous colitis, and ...
Francesca Tondi, Roberta Annamaria Cirsmaru, Chiara Conti, Antonia Follenzi, Paolo Gresele, Cristina Olgasi, Loredana Bury   +6 more
wiley   +1 more source

Curcumin inhibits the replication of enterovirus 71 in vitro

Acta Pharmaceutica Sinica B, 2014
Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades, and no vaccine and effective antiviral medicine are ...
Ying Qin, Lexun Lin, Yang Chen, Shuo Wu, Xiaoning Si, Heng Wu, Xia Zhai, Yan Wang, Lei Tong, Bo Pan, Xiaoyan Zhong, Tianying Wang, Wenran Zhao, Zhaohua Zhong   +13 more
doaj   +1 more source

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

Journal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.
ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang, Ben J. Hayes, Russell E. Lyons, Imtiaz A. S. Randhawa, John B. Gaughan, Nguyen X. Trach, David M. McNeill   +6 more
wiley   +1 more source

Effects of Picornavirus 3A Proteins on Protein Transport and GBF1-Dependent COP-I Recruitment [PDF]

Journal of Virology, 2006
ABSTRACT The 3A protein of the coxsackievirus B3 (CVB3), an enterovirus that belongs to the family of the picornaviruses, inhibits endoplasmic reticulum-to-Golgi transport. Recently, we elucidated the underlying mechanism by showing that CVB3 3A interferes with ADP-ribosylation factor 1 (Arf1)-dependent COP-I recruitment to membranes by ...
Wessels, E., Duijsings, D.M., Lanke, K.H.W., Dooren, S.H.J. van, Jackson, C.L., Melchers, W.J.G., Kuppeveld, F.J.M. van   +6 more
openaire   +5 more sources

TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

Traffic, Volume 26, Issue 4-6, April‐June 2025.
Epithelial‐immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how the inflammatory cytokine TNF‐α modifies epithelial cell function without impacting barrier function.
Syntyche Ngalula, Cathleen R. Carlin
wiley   +1 more source

Unequal Genetic Redundancies Among MYC bHLH Transcription Factors Underlie Seedling Photomorphogenesis in Arabidopsis

Plant Direct, Volume 9, Issue 2, February 2025.
ABSTRACT Light is one of the most critical ecological cues controlling plant growth and development. Plants have evolved complex mechanisms to cope with fluctuating light signals. In Arabidopsis, bHLH transcription factors MYC2, MYC3, and MYC4 have been shown to play a vital role in protecting plants against herbivory and necrotrophic pathogens.
Vikas Garhwal, Sreya Das, Sreeramaiah N. Gangappa   +2 more
wiley   +1 more source