Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
doaj +2 more sources
Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. [PDF]
PLoS ONE, 2009 In mammalian cells, endocytosis of the fluid phase and glycosylphosphatidylinositol-anchored proteins (GPI-APs) forms GEECs (GPI-AP enriched early endosomal compartments) via an Arf1- and Cdc42-mediated, dynamin independent mechanism.
Gagan D Gupta +5 more
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Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
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Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells. [PDF]
PLoS ONE, 2013 Recent reports indicate that the replication of hepatitis C virus (HCV) depends on the GBF1-Arf1-COP-I pathway. We generated Huh-7-derived cell lines resistant to brefeldin A (BFA), which is an inhibitor of this pathway. The resistant cell lines could be
Rayan Farhat +7 more
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Spatial-Temporal Study of Rab1b Dynamics and Function at the ER-Golgi Interface. [PDF]
PLoS ONE, 2016 The GTPase Rab1b is involved in ER to Golgi transport, with multiple Rab1b effectors (located at ERES, VTCs and the Golgi complex) being required for its function.
Hernán Martinez +3 more
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Chlamydial infection from outside to inside [PDF]
, 2019 Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic developmental cycle. Specific interactions with the host cell are crucial for the bacteria's survival and amplification because of the reduced chlamydial genome.
Gitsels, Arlieke +2 more
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Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association [PDF]
Molecular Biology of the Cell, 2007 Assembly of the cytosolic coat protein I (COPI) complex at the ER–Golgi interface is directed by the ADP ribosylation factor1 (Arf1) and its guanine nucleotide exchange factor (GBF1). Rab1b GTPase modulates COPI recruitment, but the molecular mechanism underlying this action remains unclear.
Monetta, Pablo Miguel +3 more
openaire +3 more sources
CD2v interacts with Adaptor Protein AP-1 during African swine fever infection [PDF]
, 2015 African swine fever virus (ASFV) CD2v protein is believed to be involved in virulence enhancement, viral hemadsorption, and pathogenesis, although the molecular mechanisms of the function of this viral protein are still not fully understood.
Pérez-Núñez, Daniel +6 more
core +11 more sources
Human Rhinovirus 16 Causes Golgi Apparatus Fragmentation without Blocking Protein Secretion [PDF]
, 2014 The replication of picornaviruses has been described to cause fragmentation of the Golgi apparatus that blocks the secretory pathway. The inhibition of major histocompatibility complex class I upregulation and cytokine, chemokine and interferon secretion
Guedan, A +7 more
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Skeletal muscle perilipin 3 and coatomer proteins are increased following exercise and are associated with fat oxidation. [PDF]
PLoS ONE, 2014 Lipid droplet-associated proteins such as perilipin 3 (PLIN3) and coatomer GTPase proteins (GBF1, ARF1, Sec23a, and ARFRP1) are expressed in skeletal muscle but little is known so far as to their regulation of lipolysis.
Jeffrey D Covington +7 more
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