Results 51 to 60 of about 1,851 (152)

Correlation Between the Evolution of Somatic Alterations During Lymphatic Metastasis and Clinical Outcome in Penile Squamous Cell Carcinoma

Frontiers in Oncology, 2021
Penile squamous cell carcinoma (PSCC) is a rare malignancy with poor survival after standard treatment. Although genomic alterations of PSCC have been characterized in several latest studies, the association between the formation of somatic landscape and
Jian Cao, Chun-He Yang, Wei-Qing Han, Yu Xie, Zhi-Zhong Liu, Shu-Suan Jiang   +5 more
doaj   +1 more source

The role of GBF1 in Golgi biogenesis and secretory traffic. [PDF]

, 2009
The secretory pathway within a cell consists of series of membrane compartments connected by shuttling secretory vesicles containing cargo that travel from endoplasmic reticulum (ER) though ER-to-Golgi intermediate compartment (ERGIC), the Golgi ...
Szul, Tomasz
core  

Class I ADP-ribosylation factors are involved in enterovirus 71 replication.

PLoS ONE, 2014
Enterovirus 71 is one of the major causative agents of hand, foot, and mouth disease in infants and children. Replication of enterovirus 71 depends on host cellular factors.
Jianmin Wang, Jiang Du, Qi Jin
doaj   +1 more source

Explore the role of long noncoding RNAs and mRNAs in intracranial atherosclerotic stenosis: From the perspective of neutrophils

Brain Circulation, 2023
CONTEXT: Circulating neutrophils and long noncoding RNAs (lncRNAs) play various roles in intracranial atherosclerotic stenosis (ICAS). OBJECTIVE: Our study aimed to detect differentially expressed (DE) lncRNAs and mRNAs in circulating neutrophils and ...
Yilin Wang, Tao Wang, Ziping Han, Rongliang Wang, Yue Hu, Zhenhong Yang, Tong Shen, Yangmin Zheng, Jichang Luo, Yan Ma, Yumin Luo, Liqun Jiao   +11 more
doaj   +1 more source

Guanine Nucleotide Exchange Factors and Small GTPases: Their Regulation and Functions, Diseases, and Therapeutic Targets

MedComm, Volume 6, Issue 10, October 2025.
This review comprehensively examines the regulatory mechanisms and physiological roles of guanine nucleotide exchange factors (GEFs) and their small GTPase substrates, highlighting their significance in cellular processes and disease pathogenesis.
Zexing Lin, Chujun Ni, Haiyang Jiang, Huan Yang, Liting Deng, Peizhao Liu, Xuanheng Li, Yilong Yu, Weijie Li, Runnan Wang, Bo Liao, Jiaqi Kang, Juanhan Liu, Xiuwen Wu, Jianan Ren, Yun Zhao   +15 more
wiley   +1 more source

Curcumin inhibits the replication of enterovirus 71 in vitro

Acta Pharmaceutica Sinica B, 2014
Human enterovirus 71 (EV71) is the main causative pathogen of hand, foot, and mouth disease (HFMD) in children. The epidemic of HFMD has been a public health problem in Asia-Pacific region for decades, and no vaccine and effective antiviral medicine are ...
Ying Qin, Lexun Lin, Yang Chen, Shuo Wu, Xiaoning Si, Heng Wu, Xia Zhai, Yan Wang, Lei Tong, Bo Pan, Xiaoyan Zhong, Tianying Wang, Wenran Zhao, Zhaohua Zhong   +13 more
doaj   +1 more source

BnaC04.bZIP16 can be phosphorylated and inhibited by BnaA06.SnRK2 and negatively regulates the accumulation of fatty acids in Brassica napus

The Plant Journal, Volume 124, Issue 1, October 2025.
SUMMARY Brassica napus is an important oil crop with a significant amount of fatty acid in its seeds. However, the molecular mechanisms of fatty acid synthesis and accumulation are still poorly understood. In this study, we identified a transcription factor, BnaC04.bZIP16, which belongs to the G subfamily of the bZIP family, that negatively regulates ...
Wei Hui, Shuangshuang Li, Jinhao Ding, Qianru Li, Yuhong Chen, Yanhui Wang, Xupeng Guo, Chengming Fan, Zanmin Hu   +8 more
wiley   +1 more source

Hermansky‐Pudlak Syndrome: From Molecular Pathogenesis to Targeted Therapies

IUBMB Life, Volume 77, Issue 5, May 2025.
ABSTRACT Hermansky‐Pudlak syndrome (HPS) is a rare inherited disorder caused by defects in lysosome‐related organelles (LROs) in various tissues, including platelets, melanocytes, and endothelial cells. Key features of HPS include oculocutaneous albinism, bleeding tendency, and, in some cases, pulmonary fibrosis, granulomatous colitis, and ...
Francesca Tondi, Roberta Annamaria Cirsmaru, Chiara Conti, Antonia Follenzi, Paolo Gresele, Cristina Olgasi, Loredana Bury   +6 more
wiley   +1 more source

Genomic Prediction and Genome‐Wide Association Studies for Productivity, Conformation and Heat Tolerance Traits in Tropical Smallholder Dairy Cows

Journal of Animal Breeding and Genetics, Volume 142, Issue 3, Page 322-341, May 2025.
ABSTRACT Genomic selection (GS) and genome‐wide association studies (GWAS) have not been investigated in Vietnamese dairy cattle, even for basic milk production traits, largely due to the scarcity of individual phenotype recording in smallholder dairy farms (SDFs).
Nguyen N. Bang, Ben J. Hayes, Russell E. Lyons, Imtiaz A. S. Randhawa, John B. Gaughan, Nguyen X. Trach, David M. McNeill   +6 more
wiley   +1 more source

TNF‐α‐Driven Changes in Polarized EGF Receptor Trafficking Facilitate Phosphatidylinositol 3‐Kinase/Protein Kinase B Signaling From the Apical Surface of MDCK Epithelial Cells

Traffic, Volume 26, Issue 4-6, April‐June 2025.
Epithelial‐immune cell crosstalk is tightly regulated by secretion of immune cell mediators into luminal and serosal fluid spaces of epithelial tissues. We report two major new findings regarding how the inflammatory cytokine TNF‐α modifies epithelial cell function without impacting barrier function.
Syntyche Ngalula, Cathleen R. Carlin
wiley   +1 more source