Results 31 to 40 of about 1,805 (175)
Toxoplasma and Plasmodium associate with host Arfs during infection [PDF]
mSphereThe apicomplexans Toxoplasma gondii and Plasmodium are intracellular parasites that reside within a host-derived compartment termed the parasitophorous vacuole (PV).
Erin A. Schroeder +5 more
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Lipids and Traffic : roles of the large Arf1-GEF GBF1
, 2013 The eukaryotic cell physically separates its functions within several membrane-bound organelles, which communicate using vesicles. Vesicular trafficking is under the control of small GTPases that exist as an inactive GDP-bound form and an active GTP-bound form.
Bouvet, Samuel
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The Journal of Cell Biology, 1999 Expression cloning from a cDNA library prepared from a mutant CHO cell line with Golgi-specific resistance to Brefeldin A (BFA) identified a novel 206-kD protein with a Sec7 domain termed GBF1 for Golgi BFA resistance factor 1. Overexpression of GBF1 allowed transfected cells to maintain normal Golgi morphology and grow in the presence of BFA.
Alejandro Claude +8 more
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Characterization of the GBF1-Arf1 axis in enterovirus RNA replication
The Enterovirus genus includes many known and emerging pathogens, such as poliovirus, enteroviruses A71 and D68, rhinoviruses, and others. Enterovirus infection induces the massive remodeling of intracellular membranes and the development of specialized domains harboring viral replication complexes, called replication organelles.
Gabaglio Velazquez, Samuel Maria
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AMPK phosphorylates GBF1 for mitotic Golgi disassembly [PDF]
Journal of Cell Science, 2013 In mammalian cells, the Golgi apparatus undergoes extensive fragmentation during mitosis; this is required not only for the partitioning of the complex but also for the process of mitosis. However, the molecular mechanism underlying the mitotic fragmentation of the Golgi is far from clear.
Luna, Mao +7 more
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The role of GBF1 and GlcCer in UUKV infection [PDF]
, 2022 During the past decades, highly pathogenic arthropod-borne viruses (arboviruses) have emerged globally, posing a threat to public health. Arboviruses not only replicate in their vertebrate hosts but feature a dual life cycle with a switch to and from their arthropod vector.
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GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis [PDF]
Journal of Cell Science, 2012 Here we report on the generation and in vivo analysis of a series of loss-of-function mutants for the Drosophila ArfGEF, Gartenzwerg. The Drosophila gene gartenzwerg (garz) encodes the orthologue of mammalian GBF1. garz is expressed ubiquitously in embryos with substantially higher abundance in cells forming diverse tubular structures such as salivary ...
Wang, Shuoshuo +8 more
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A critical role of a cellular membrane traffic protein in poliovirus RNA replication. [PDF]
PLoS Pathogens, 2008 Replication of many RNA viruses is accompanied by extensive remodeling of intracellular membranes. In poliovirus-infected cells, ER and Golgi stacks disappear, while new clusters of vesicle-like structures form sites for viral RNA synthesis.
George A Belov +4 more
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Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast. [PDF]
PLoS ONE, 2013 Membrane trafficking is essential to eukaryotic life and is controlled by a complex network of proteins that regulate movement of proteins and lipids between organelles.
Alan M Eckler +13 more
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Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
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