Mechanical Cues Regulate Cargo Sorting and Export at the Golgi [PDF]
Advanced ScienceThe secretory pathway is a sophisticated endomembrane machinery designed to transport and deliver proteins and lipids to intracellular organelles and the extracellular space.
Greta Serafino +21 more
doaj +3 more sources
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1. [PDF]
J VirolEnteroviruses are single-stranded, positive-sense RNA viruses causing endoplasmic reticulum (ER) stress to induce or modulate downstream signaling pathways known as the unfolded protein responses (UPR). However, viral and host factors involved in the UPR
Hirano J +12 more
europepmc +4 more sources
Phosphorylation Affects DNA-Binding of the Senescence-Regulating bZIP Transcription Factor GBF1 [PDF]
Plants, 2015 Massive changes in the transcriptome of Arabidopsis thaliana during onset and progression of leaf senescence imply a central role for transcription factors. While many transcription factors are themselves up- or down-regulated during senescence, the bZIP
Anja Smykowski +2 more
exaly +5 more sources
A GBF1-Dependent Mechanism for Environmentally Responsive Regulation of ER-Golgi Transport [PDF]
Developmental Cell, 2019 Summary How can anterograde membrane trafficking be modulated by physiological cues? A screen of Golgi-associated proteins revealed that the ARF-GEF GBF1 can selectively modulate the ER-Golgi trafficking of prohaemostatic von Willebrand factor (VWF) and ...
Mafalda Lopes da Silva +2 more
exaly +5 more sources
AG1478 Elicits a Novel Anti-Influenza Function via an EGFR-Independent, GBF1-Dependent Pathway. [PDF]
Int J Mol Sci, 2022 Current options for preventing or treating influenza are still limited, and new treatments for influenza viral infection are urgently needed. In the present study, we serendipitously found that a small-molecule inhibitor (AG1478), previously used for ...
Zhou X +5 more
europepmc +4 more sources
Highly conserved motifs within the large Sec7 ARF guanine nucleotide exchange factor GBF1 target it to the Golgi and are critical for GBF1 activity [PDF]
American Journal of Physiology - Cell Physiology, 2018 Cellular life requires the activation of the ADP-ribosylation factors (ARFs) by Golgi brefeldin A-resistant factor 1 (GBF1), a guanine nucleotide exchange factor (GEF) with a highly conserved catalytic Sec7 domain (Sec7d).
Ekaterina G Viktorova +2 more
exaly +5 more sources
The Arf activator GBF1 localizes to plasma membrane sites involved in cell adhesion and motility [PDF]
Cellular Logistics, 2017 GBF1 is ubiquitously expressed in eukaryotic cells and is essential for cellular and organismal life. Depletion of GBF1 from cultured cells induces apoptosis, while mouse GBF1 knockout and D.
Justyna M Meissner +2 more
exaly +4 more sources
Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease. [PDF]
Alzheimers DementDespite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation.
Miller SJ +16 more
europepmc +2 more sources
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. [PDF]
PLoS Pathogens, 2008 Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the endoplasmic
Monique H Verheije +7 more
doaj +8 more sources
The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses [PDF]
Acta Pharmaceutica Sinica B, 2023 Positive-sense RNA viruses modify intracellular calcium stores, endoplasmic reticulum and Golgi apparatus (Golgi) to generate membranous replication organelles known as viral factories.
Kan Xing Wu +11 more
doaj +2 more sources