Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1 [PDF]
Cell Reports, 2018 Summary: Although much is known about how chromosome segregation is coupled to cell division, how intracellular organelles partition during mitotic division is poorly understood. We report that the phosphorylation-dependent degradation of the ARFGEF GBF1
Roberto Magliozzi +2 more
exaly +10 more sources
Phosphorylation Affects DNA-Binding of the Senescence-Regulating bZIP Transcription Factor GBF1 [PDF]
Plants, 2015 Massive changes in the transcriptome of Arabidopsis thaliana during onset and progression of leaf senescence imply a central role for transcription factors. While many transcription factors are themselves up- or down-regulated during senescence, the bZIP
Ulrike Zentgraf, Zentgraf Ulrike
exaly +6 more sources
Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1.
PLoS ONE, 2011 The Arf1 exchange factor GBF1 (Golgi Brefeldin A resistance factor 1) and its effector COPI are required for delivery of ATGL (adipose triglyceride lipase) to lipid droplets (LDs).
Emy Njoh Ellong +5 more
doaj +8 more sources
Src activates retrograde membrane traffic through phosphorylation of GBF1 [PDF]
eLife, 2021 The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown.
Joanne Chia +8 more
doaj +4 more sources
Charakterisierung des Guaninnukleotid-Austauschfaktors GBF1 [PDF]
, 2009 Im initiierenden Schritt der COPI-Vesikelbiogenese wird die kleine GTPase Arf1 von den beiden zur p24 Proteinfamilie gehorenden Typ I-Trans-membranproteinen p23 bzw. p24 an die Membran rekrutiert. Dort vermittelt GBF1 (Golgi-specific brefeldin A-resistance factor 1), ein sogenanntes Arf GEF (guanine nucleotide exchange factor), in Arf1 den ...
Hubich, Stefanie
openaire +2 more sources
The phosphatidylinositol 4-kinase PI4KIIIα is required for the recruitment of GBF1 to Golgi membranes [PDF]
Journal of Cell Science, 2010 Sorting from the Golgi apparatus requires the recruitment of cytosolic coat proteins to package cargo into trafficking vesicles. An important early step in the formation of trafficking vesicles is the activation of Arf1 by the guanine nucleotide exchange factor GBF1.
Karine, Dumaresq-Doiron +4 more
openaire +3 more sources
A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replication. [PDF]
PLoS Pathogens, 2022 As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication.
Seyedehmahsa Moghimi +7 more
doaj +2 more sources
Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis [PDF]
Biochemical Journal, 2010 Secretory protein trafficking is arrested and the Golgi apparatus fragmented when mammalian cells enter mitosis. These changes are thought to facilitate cell-cycle progression and Golgi inheritance, and are brought about through the actions of mitotically active protein kinases.
Morohashi, Y +4 more
openaire +7 more sources
Golgicide A reveals essential roles for GBF1 in Golgi assembly and function [PDF]
Nature Chemical Biology, 2009 ADP ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs), which confer spatial and temporal specificity to vesicular transport.
Saenz, Jose B. +6 more
openaire +6 more sources
Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. [PDF]
PLoS Pathogens, 2008 Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the endoplasmic
Monique H Verheije +7 more
doaj +8 more sources