Results 1 to 10 of about 1,805 (175)

Site-specific phosphorylations of the Arf activator GBF1 differentially regulate GBF1 function in Golgi homeostasis and secretion versus cytokinesis [PDF]

Scientific Reports, 2023
Diverse cellular processes, including membrane traffic, lipid homeostasis, cytokinesis, mitochondrial positioning, and cell motility are critically dependent on the Sec7 domain guanine nucleotide exchange factor GBF1.
Kendall Walton, Tomasz J. Nawara, Allyson R. Angermeier, Hadley Rosengrant, Eunjoo Lee, Bridge Wynn, Ekaterina Victorova, George Belov, Elizabeth Sztul   +8 more
doaj   +5 more sources

The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi [PDF]

Frontiers in Cell and Developmental Biology, 2023
Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process.
Tomasz Szul, Kahn Richard A, Sztul Elizabeth   +2 more
exaly   +6 more sources

Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses [PDF]

Viruses, 2020
The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
JOSÉ L Martinez, CARLOS F Arias, Arias CARLOS F   +2 more
exaly   +6 more sources

Mechanical Cues Regulate Cargo Sorting and Export at the Golgi [PDF]

Advanced Science
The secretory pathway is a sophisticated endomembrane machinery designed to transport and deliver proteins and lipids to intracellular organelles and the extracellular space.
Greta Serafino, Stefania Forciniti, Edoardo Scarpa, Antonio Ranieri, Lucia Santorelli, Gabriella De Blasi, Sara Costantini, Eunjoo Jun Lee, Antonio Galeone, Alessia Calcagnì, Marinella Pirozzi, Loretta L. delMercato, Rossella Venditti, Giovanni D'Angelo, Seetharaman Parashuraman, Tiziano Verri, Giuseppe Gigli, Elizabeth S. Sztul, Paolo Grumati, Loris Rizzello, Domenico Russo, Riccardo Rizzo   +21 more
doaj   +3 more sources

The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1. [PDF]

PLoS Pathogens, 2023
The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide exchange factor), is recruited to the replication organelles of enteroviruses through interaction with the viral protein 3A, and its ArfGEF activity is required for ...
Ekaterina G Viktorova, Samuel Gabaglio, Seyedehmahsa Moghimi, Anna Zimina, Bridge G Wynn, Elizabeth Sztul, George A Belov   +6 more
doaj   +2 more sources

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease. [PDF]

Alzheimers Dement
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Miller SJ, Prokopenko D, Bai P, Mondal P, Scott A, Zhang W, Gomm A, Zhang S, Child DD, Shen N, Ward J, Schulte S, Lei D, Hafler BP, Wang C, Tanzi RE, Zhang C.   +16 more
europepmc   +2 more sources

Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses [PDF]

iScience
Summary: Influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are respiratory pathogens that continue to challenge global health due to their efficient transmission and ability to circumvent virus-specific treatments ...
Victoria Simanihuruk, Yurie Kida, Kosuke Takada, Harumi Yamaguma, Natsumi Kameoka, Itsuki Anzai, Shintaro Shichinohe, Satoshi Obika, Yuuya Kasahara, Tokiko Watanabe   +9 more
doaj   +2 more sources

The Role of the CLIC/GEEC Endocytic Pathway for Mechanophysical Transfection of DNA. [PDF]

J Gene Med
The clathrin‐independent carriers/GPI‐enriched endocytic compartments (CLIC/GEEC or CG) pathway is a high‐capacity, clathrin‐, and dynamin‐independent route for nutrient and membrane‐anchored cargo uptake of DNA. This overview highlights its molecular mechanisms, regulation, cellular roles, and relevance to mechanophysical DNA transfection.
Weaver S, Lallow EO, Kyker-Snowman K, Jhumur NC, Gulley M, Roberts CC, Shreiber DI, Lin H, Maslow JN.   +8 more
europepmc   +2 more sources

The host-targeting compound peruvoside has a broad-spectrum antiviral activity against positive-sense RNA viruses [PDF]

Acta Pharmaceutica Sinica B, 2023
Positive-sense RNA viruses modify intracellular calcium stores, endoplasmic reticulum and Golgi apparatus (Golgi) to generate membranous replication organelles known as viral factories.
Kan Xing Wu, Thinesshwary Yogarajah, Marcus Wing Choy Loe, Parveen Kaur, Regina Ching Hua Lee, Chee Keng Mok, Yi Hao Wong, Patchara Phuektes, Li Sze Yeo, Vincent T.K. Chow, Yong Wah Tan, Justin Jang Hann Chu   +11 more
doaj   +2 more sources

The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction

Frontiers in Cell and Developmental Biology, 2021
Bone-resorbing activities of osteoclasts (OCs) are highly dependent on actin cytoskeleton remodeling, plasma membrane reorganization, and vesicle trafficking pathways, which are partially regulated by ARF-GTPases.
Chun Zhou, Zhou Chun, Tian Qin
exaly   +3 more sources