Site-specific phosphorylations of the Arf activator GBF1 differentially regulate GBF1 function in Golgi homeostasis and secretion versus cytokinesis [PDF]
Scientific Reports, 2023 Diverse cellular processes, including membrane traffic, lipid homeostasis, cytokinesis, mitochondrial positioning, and cell motility are critically dependent on the Sec7 domain guanine nucleotide exchange factor GBF1.
Kendall Walton +8 more
doaj +5 more sources
Role of the Guanine Nucleotide Exchange Factor GBF1 in the Replication of RNA Viruses [PDF]
Viruses, 2020 The guanine nucleotide exchange factor GBF1 is a well-known factor that can activate different ADP-ribosylation factor (Arf) proteins during the regulation of different cellular vesicular transport processes.
Jose L Martinez, Carlos F Arias
exaly +6 more sources
Inheritance of the Golgi Apparatus and Cytokinesis Are Controlled by Degradation of GBF1 [PDF]
Cell Reports, 2018 Summary: Although much is known about how chromosome segregation is coupled to cell division, how intracellular organelles partition during mitotic division is poorly understood. We report that the phosphorylation-dependent degradation of the ARFGEF GBF1
Teck Yew Low +2 more
exaly +8 more sources
The Arf-GEF GBF1 undergoes multi-domain structural shifts to activate Arf at the Golgi [PDF]
Frontiers in Cell and Developmental Biology, 2023 Golgi homeostasis require the activation of Arf GTPases by the guanine-nucleotide exchange factor requires GBF1, whose recruitment to the Golgi represents a rate limiting step in the process.
Justyna M. Meissner +10 more
doaj +3 more sources
Broad-spectrum antiviral activity of antisense oligonucleotides targeting GBF1 against SARS-CoV-2 and influenza viruses [PDF]
iScienceSummary: Influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are respiratory pathogens that continue to challenge global health due to their efficient transmission and ability to circumvent virus-specific treatments ...
Victoria Simanihuruk +9 more
doaj +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Bone-resorbing activities of osteoclasts (OCs) are highly dependent on actin cytoskeleton remodeling, plasma membrane reorganization, and vesicle trafficking pathways, which are partially regulated by ARF-GTPases.
Chun Zhou
exaly +4 more sources
An interplay between bZIP16, bZIP68, and GBF1 regulates nuclear photosynthetic genes during photomorphogenesis in Arabidopsis. [PDF]
New Phytol, 2023 The development of a seedling into a photosynthetically active plant is a crucial process. Despite its importance, we do not fully understand the regulatory mechanisms behind the establishment of functional chloroplasts.
Norén Lindbäck L +5 more
europepmc +2 more sources
The development of resistance to an inhibitor of a cellular protein reveals a critical interaction between the enterovirus protein 2C and a small GTPase Arf1. [PDF]
PLoS Pathogens, 2023 The cellular protein GBF1, an activator of Arf GTPases (ArfGEF: Arf guanine nucleotide exchange factor), is recruited to the replication organelles of enteroviruses through interaction with the viral protein 3A, and its ArfGEF activity is required for ...
Ekaterina G Viktorova +6 more
doaj +2 more sources
A Novel <i>GBF1</i> Variant in a Charcot-Marie-Tooth Type 2: Insights from Familial Analysis. [PDF]
Genes (Basel)Background/Objectives: Axonal Charcot–Marie–Tooth disease type 2 (CMT2) accounts for 24% of Hereditary Motor/Sensory Peripheral Neuropathies. CMT2 type GG, due to four distinct heterozygous mutations in the Golgi brefeldin A resistant guanine nucleotide ...
Ciampana V +6 more
europepmc +2 more sources
Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality. [PDF]
J Cell Biol, 2022 Using a viral-induced hypomorph of GBF1, Navare et al. demonstrate that the principle of synthetic lethality is a mechanism to selectively kill virus-infected cells.
Navare AT +9 more
europepmc +2 more sources