Results 21 to 30 of about 3,458 (213)
J Cell SciAMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular functions in response to changes in energy availability. However, whether AMPK activity is spatially regulated, and the implications for cell function, have been unclear.
Freemantle JB +8 more
europepmc +2 more sources
Src activates retrograde membrane traffic through phosphorylation of GBF1 [PDF]
eLife, 2020 The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown.
J. Chia +8 more
semanticscholar +5 more sources
Rab1b-GBF1-ARF1 Secretory Pathway Axis Is Required for Birnavirus Replication
Journal of Virology, 2021 Birnaviruses are unconventional members of the dsRNA viruses, with the lack of a transcriptionally active core being the main differential feature. This structural trait, among others that resemble those of the plus single-stranded (+ssRNA) viruses ...
M. C. Giménez +8 more
semanticscholar +4 more sources
Interaction between the triglyceride lipase ATGL and the Arf1 activator GBF1.
PLoS ONE, 2011 The Arf1 exchange factor GBF1 (Golgi Brefeldin A resistance factor 1) and its effector COPI are required for delivery of ATGL (adipose triglyceride lipase) to lipid droplets (LDs).
Emy Njoh Ellong +5 more
doaj +5 more sources
A Proximity biotinylation assay with a host protein bait reveals multiple factors modulating enterovirus replication. [PDF]
PLoS Pathogens, 2022 As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication.
Seyedehmahsa Moghimi +7 more
doaj +2 more sources
Golgicide A Reveals Essential Roles for GBF1 in Golgi Assembly and Function [PDF]
Nature Chemical Biology, 2013 ADP-ribosylation factor 1 (Arf1) plays a critical role in regulating secretory traffic and membrane transport within the Golgi of eukaryotic cells. Arf1 is activated by guanine nucleotide exchange factors (ArfGEFs) which confer spatial and temporal ...
Bursulaya, Badry +6 more
core +5 more sources
The Guanine Nucleotide Exchange Factor GBF1 Participates in Rotavirus Replication [PDF]
Journal of Virology, 2019 Rotavirus, a member of the family Reoviridae, is the major cause of severe diarrhea in children and young animals worldwide. Despite significant advances in the characterization of the biology of this virus, the mechanisms involved in morphogenesis of ...
J. Martínez +9 more
semanticscholar +4 more sources
A synthetic lethal interaction with a viral-induced hypomorph of GBF1 [PDF]
Journal of Cell Biology, 2020 Viruses co-opt host proteins to carry out replication of the virus. Host proteins thus repurposed may become functionally compromised, a situation analogous to a loss-of-function allele, which we term a viral-induced hypomorph.
Arti T. Navare +7 more
semanticscholar +5 more sources
Molecular and Cellular Proteomics, 2019 The Golgi-specific Brefeldin-A resistance factor 1 (GBF1) regulates Arf activation at the cis-Golgi. BioID and mass spectrometry from Golgi-enriched fractions identified C10orf76 as a GBF1 proximal protein that may regulate its recruitment.
Etienne Coyaud +2 more
exaly +2 more sources
GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins [PDF]
Frontiers in Cell and Developmental Biology, 2022 Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects
Amrita Khakurel +4 more
doaj +2 more sources