A critical role of a cellular membrane traffic protein in poliovirus RNA replication. [PDF]
PLoS Pathogens, 2008 Replication of many RNA viruses is accompanied by extensive remodeling of intracellular membranes. In poliovirus-infected cells, ER and Golgi stacks disappear, while new clusters of vesicle-like structures form sites for viral RNA synthesis.
George A Belov +4 more
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Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast. [PDF]
PLoS ONE, 2013 Membrane trafficking is essential to eukaryotic life and is controlled by a complex network of proteins that regulate movement of proteins and lipids between organelles.
Alan M Eckler +13 more
doaj +1 more source
Repression of ZCT1, ZCT2 and ZCT3 affects expression of terpenoid indole alkaloid biosynthetic and regulatory genes [PDF]
PeerJ, 2021 Terpenoid indole alkaloids (TIAs) include several valuable pharmaceuticals. As Catharanthus roseus remains the primary source of these TIA pharmaceuticals, several research groups have devoted substantial efforts to increase production of these compounds
Chun Yao Li, Susan I. Gibson
doaj +2 more sources
Analysis of endocytic pathways in Drosophila cells reveals a conserved role for GBF1 in internalization via GEECs. [PDF]
PLoS ONE, 2009 In mammalian cells, endocytosis of the fluid phase and glycosylphosphatidylinositol-anchored proteins (GPI-APs) forms GEECs (GPI-AP enriched early endosomal compartments) via an Arf1- and Cdc42-mediated, dynamin independent mechanism.
Gagan D Gupta +5 more
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Mouse hepatitis coronavirus RNA replication depends on GBF1-mediated ARF1 activation. [PDF]
PLoS Pathogens, 2008 Coronaviruses induce in infected cells the formation of double membrane vesicles, which are the sites of RNA replication. Not much is known about the formation of these vesicles, although recent observations indicate an important role for the endoplasmic
Monique H Verheije +7 more
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Charakterisierung des Guaninnukleotid-Austauschfaktors GBF1 [PDF]
, 2009 Im initiierenden Schritt der COPI-Vesikelbiogenese wird die kleine GTPase Arf1 von den beiden zur p24 Proteinfamilie gehörenden Typ I-Trans-membranproteinen p23 bzw. p24 an die Membran rekrutiert.
Hubich, Stefanie
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Hepatitis C virus replication and Golgi function in brefeldin a-resistant hepatoma-derived cells. [PDF]
PLoS ONE, 2013 Recent reports indicate that the replication of hepatitis C virus (HCV) depends on the GBF1-Arf1-COP-I pathway. We generated Huh-7-derived cell lines resistant to brefeldin A (BFA), which is an inhibitor of this pathway. The resistant cell lines could be
Rayan Farhat +7 more
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Spatial-Temporal Study of Rab1b Dynamics and Function at the ER-Golgi Interface. [PDF]
PLoS ONE, 2016 The GTPase Rab1b is involved in ER to Golgi transport, with multiple Rab1b effectors (located at ERES, VTCs and the Golgi complex) being required for its function.
Hernán Martinez +3 more
doaj +1 more source
PLoS Pathogens, 2022 As ultimate parasites, viruses depend on host factors for every step of their life cycle. On the other hand, cells evolved multiple mechanisms of detecting and interfering with viral replication.
Seyedehmahsa Moghimi +7 more
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Identification and functional characterization of the GBF1-controlled network of host proteins supporting enterovirus replication [PDF]
, 2022 The genus Enterovirus of the Picornaviridae family contains many established and emerging pathogens. However, licensed vaccines are currently available only against poliovirus and enterovirus A71.
Moghimi, Seyedehmahsa
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