Results 41 to 50 of about 3,458 (213)

Combined Transcriptomic and Metabolomic Analysis Reveals an Ethylene-Activated Regulatory Model on Monoterpenoid Indole Alkaloid Biosynthesis in Catharanthus roseus. [PDF]

Plant Biotechnol J
ABSTRACT Catharanthus roseus contains nearly 200 bioactive monoterpenoid indole alkaloids (MIAs) that are effective in treating cancer and other diseases. Ethylene plays a significant role in enhancing MIA biosynthesis, and we have found that it greatly induces the accumulation of anhydrovinblastine.
Deng B, Miao Q, Ou C, Pan Y, Liu H, Fu X, Li L, Wang Y, Tang K, Pan Q.   +9 more
europepmc   +2 more sources

Src activates retrograde membrane traffic through phosphorylation of GBF1

eLife, 2021
The Src tyrosine kinase controls cancer-critical protein glycosylation through Golgi to ER relocation of GALNTs enzymes. How Src induces this trafficking event is unknown.
Joanne Chia, Shyi-Chyi Wang, Sheena Wee, David James Gill, Felicia Tay, Srinivasaraghavan Kannan, Chandra S Verma, Jayantha Gunaratne, Frederic A Bard   +8 more
doaj   +1 more source

Gbf1 [PDF]

The Journal of Cell Biology, 1999
Expression cloning from a cDNA library prepared from a mutant CHO cell line with Golgi-specific resistance to Brefeldin A (BFA) identified a novel 206-kD protein with a Sec7 domain termed GBF1 for Golgi BFA resistance factor 1. Overexpression of GBF1 allowed transfected cells to maintain normal Golgi morphology and grow in the presence of BFA.
Alejandro Claude, Bao-Ping Zhao, Craig E. Kuziemsky, Sophie Dahan, Scott J. Berger, Jian-Ping Yan, Adrian D. Armold, Eric M. Sullivan, Paul Melançon   +8 more
openaire   +1 more source

AMPK phosphorylates GBF1 for mitotic Golgi disassembly [PDF]

Journal of Cell Science, 2013
In mammalian cells, the Golgi apparatus undergoes extensive fragmentation during mitosis; this is required not only for the partitioning of the complex but also for the process of mitosis. However, the molecular mechanism underlying the mitotic fragmentation of the Golgi is far from clear.
Luna, Mao, Ning, Li, Yajuan, Guo, Xiaobin, Xu, Luying, Gao, Yinfeng, Xu, Linfu, Zhou, Wei, Liu   +7 more
openaire   +2 more sources

Acute GARP Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and O-Glycosylation. [PDF]

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Cartoon illustrating defects caused by GARP dysfunction. (Left) Control cells exhibit normal Golgi morphology with a stratified distribution of enzymes and trafficking machinery. (Right) Following acute VPS54 depletion, vesicle numbers increase, the trans‐Golgi enlarges, endosome‐Golgi trafficking proteins mislocalize to vesicles, and Golgi association
Khakurel A, Pokrovskaya I, Aragon-Ramirez WS, Lupashin VV.   +3 more
europepmc   +2 more sources

Disease-Associated Factors at the Endoplasmic Reticulum-Golgi Interface. [PDF]

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The ER–Golgi interface has garnered significant attention due to recent discoveries suggesting potential non‐vesicular transport mechanisms and regulation through liquid‐liquid phase separation. Numerous diseases linked to mutations in proteins located at this interface have been identified, highlighting the importance of comprehensive reviews in this ...
Maeda M, Arakawa M, Saito K.
europepmc   +2 more sources

ARF1 with Sec7 Domain-Dependent GBF1 Activates Coatomer Protein I To Support Classical Swine Fever Virus Entry

Journal of Virology, 2022
Classical swine fever (CSF), a highly contact-infectious disease caused by classical swine fever virus (CSFV) infecting domestic pigs or wild boars, has caused huge economic losses to the pig industry.
Liang Zhang, Tao Wang, Yanyan Yi, Mengzhao Song, Mingxing Jin, K. Guo, Yanming Zhang   +6 more
semanticscholar   +1 more source

GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis [PDF]

Journal of Cell Science, 2012
Here we report on the generation and in vivo analysis of a series of loss-of-function mutants for the Drosophila ArfGEF, Gartenzwerg. The Drosophila gene gartenzwerg (garz) encodes the orthologue of mammalian GBF1. garz is expressed ubiquitously in embryos with substantially higher abundance in cells forming diverse tubular structures such as salivary ...
Wang, Shuoshuo, Meyer, Heiko, Ochoa-Espinosa, Amanda, Buchwald, Ulf, Onel, Susanne, Altenhein, Benjamin, J. Heinisch, Jürgen, Affolter, Markus, Paululat, Achim   +8 more
openaire   +2 more sources

A critical role of a cellular membrane traffic protein in poliovirus RNA replication. [PDF]

PLoS Pathogens, 2008
Replication of many RNA viruses is accompanied by extensive remodeling of intracellular membranes. In poliovirus-infected cells, ER and Golgi stacks disappear, while new clusters of vesicle-like structures form sites for viral RNA synthesis.
George A Belov, Qian Feng, Krisztina Nikovics, Catherine L Jackson, Ellie Ehrenfeld   +4 more
doaj   +1 more source

Haploinsufficiency of the Sec7 guanine nucleotide exchange factor gea1 impairs septation in fission yeast. [PDF]

PLoS ONE, 2013
Membrane trafficking is essential to eukaryotic life and is controlled by a complex network of proteins that regulate movement of proteins and lipids between organelles.
Alan M Eckler, Caroline Wilder, Antonio Castanon, Veronica M Ferris, Rachael A Lamere, Benjamin A Perrin, Ross Pearlman, Blaise White, Clifton Byrd, Nicholas Ludvik, Nona Nichols, Kristen Poole-Sumrall, Elizabeth Sztul, Melanie L Styers   +13 more
doaj   +1 more source