An early secretory pathway mediated by GNOM-LIKE 1 and GNOM is essential for basal polarity establishment in Arabidopsis thaliana [PDF]
, 2015 Spatial regulation of the plant hormone indole-3-acetic acid (IAA, or auxin) is essential for plant development. Auxin gradient establishment is mediated by polarly localized auxin transporters, including PIN-FORMED (PIN) proteins. Their localization and
Doyle, Siamsa M +10 more
core +1 more source
Hijacking of multiple phospholipid biosynthetic pathways and induction of membrane biogenesis by a picornaviral 3CD protein. [PDF]
PLoS Pathogens, 2018 RNA viruses induce specialized membranous structures for use in genome replication. These structures are often referred to as replication organelles (ROs). ROs exhibit distinct lipid composition relative to other cellular membranes.
Sravani Banerjee +10 more
doaj +1 more source
Foot-and-mouth disease virus genome replication is unaffected by inhibition of type III phosphatidylinositol-4-kinases [PDF]
, 2016 Foot-and-mouth disease virus (FMDV) causes economically-damaging infections of cloven-hooved animals, with outbreaks resulting in large financial losses to the agricultural industry.
Belsham +9 more
core +1 more source
American Journal of Human Genetics, 2020 Summary Distal hereditary motor neuropathies (HMNs) and axonal Charcot-Marie-Tooth neuropathy (CMT2) are clinically and genetically heterogeneous diseases characterized primarily by motor neuron degeneration and distal weakness.
Natalia Mendoza-Ferreira +20 more
semanticscholar +1 more source
The ORCA2 transcription factor plays a key role in regulation of the terpenoid indole alkaloid pathway [PDF]
, 2013 Background: The terpenoid indole alkaloid (TIA) pathway leads to the production of pharmaceutically important drugs, such as the anticancer compounds vinblastine and vincristine.
Gibson, Susan +6 more
core +3 more sources
Journal of Cellular and Molecular Medicine, 2020 Numerous single nucleotide polymorphisms (SNPs), which have been identified as susceptibility factors for Parkinson's disease (PD) as per genome‐wide association studies, have not been fully characterized for PD patients in China.
Aonan Zhao +7 more
semanticscholar +1 more source
Phosphorylation and membrane dissociation of the ARF exchange factor GBF1 in mitosis [PDF]
Biochemical Journal, 2010 Secretory protein trafficking is arrested and the Golgi apparatus fragmented when mammalian cells enter mitosis. These changes are thought to facilitate cell-cycle progression and Golgi inheritance, and are brought about through the actions of mitotically active protein kinases.
Morohashi, Y +4 more
openaire +6 more sources
Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
Frontiers in Neurology, 2021 A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive.
Liyuan Fan +33 more
doaj +1 more source
A novel physiological role for ARF1 in the formation of bidirectional tubules from the Golgi. [PDF]
, 2017 Capitalizing on CRISPR/Cas9 gene-editing techniques and super-resolution nanoscopy, we explore the role of the small GTPase ARF1 in mediating transport steps at the Golgi.
Baddeley, David +12 more
core +2 more sources
Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO [PDF]
, 2016 published_or_final_versio
Bershadsky, AD +6 more
core +3 more sources