Results 21 to 30 of about 213,913 (289)

A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5

Journal of experimental & clinical cancer research : CR, 2022
Background RNA-binding proteins (RBPs) and circular RNAs (circRNAs) play important roles in glioblastoma multiforme (GBM). Aerobic glycolysis is a metabolic characteristic of GBM.
Jian Song, Jian Zheng, Xiaobai Liu, Weiwei Dong, Chunqing Yang, Di Wang, Xuelei Ruan, YuBo Zhao, Libo Liu, Ping Wang, Mengyang Zhang, Yunhui Liu   +11 more
semanticscholar   +1 more source

Phase 2 study of AV-GBM-1 (a tumor-initiating cell targeted dendritic cell vaccine) in newly diagnosed Glioblastoma patients: safety and efficacy assessment

Journal of experimental & clinical cancer research : CR, 2022
Background Vaccine immunotherapy may improve survival in Glioblastoma (GBM). A multicenter phase II trial was designed to determine: (1) the success rate of manufacturing the Aivita GBM vaccine (AV-GBM-1), (2) Adverse Events (AE) associated with AV-GBM-1
D. Bota, Thomas H. Taylor, D. Piccioni, C. Duma, R. Larocca, S. Kesari, J. Carrillo, M. Abedi, R. Aiken, F. Hsu, X. Kong, Candace Hsieh, Peter G Bota, G. Nistor, H. Keirstead, R. Dillman   +15 more
semanticscholar   +1 more source

Approaches to PET Imaging of Glioblastoma

Molecules, 2020
Glioblastoma multiforme (GBM) is the deadliest type of brain tumor, affecting approximately three in 100,000 adults annually. Positron emission tomography (PET) imaging provides an important non-invasive method of measuring biochemically specific targets
Lindsey R. Drake, Ansel T. Hillmer, Zhengxin Cai   +2 more
doaj   +1 more source

Cellular and molecular features related to exceptional therapy response and extreme long‐term survival in glioblastoma

Cancer Medicine, 2023
Glioblastoma Multiforme (GBM) remains the most common malignant primary brain tumor with a dismal prognosis that rarely exceeds beyond 2 years despite extensive therapy, which consists of maximal safe surgical resection, radiotherapy, and/or chemotherapy.
B. Decraene, M. Vanmechelen, P. Clement, J. F. Daisne, I. Vanden Bempt, R. Sciot, A. D. Garg, P. Agostinis, F. De Smet, S. De Vleeschouwer   +9 more
doaj   +1 more source

SPI1-induced downregulation of FTO promotes GBM progression by regulating pri-miR-10a processing in an m6A-dependent manner

Molecular Therapy: Nucleic Acids, 2022
As one of the most common post-transcriptional modifications of mRNAs and noncoding RNAs, N6-methyladenosine (m6A) modification regulates almost every aspect of RNA metabolism.
Shouji Zhang, Shulin Zhao, Yanhua Qi, Boyan Li, Huizhi Wang, Z. Pan, H. Xue, Chuandi Jin, W. Qiu, Zihang Chen, Q. Guo, Yang-Yang Fan, Jianye Xu, Zijie Gao, Shaobo Wang, Xing Guo, Lin Deng, Shilei Ni, Fuzhong Xue, Jian Wang, Rongrong Zhao, Gang Li   +21 more
semanticscholar   +1 more source

Anti-GBM-Nephritis

Die Nephrologie, 2023
ZusammenfassungAntikörper gegen die glomeruläre Basalmembran (GBM) verursachen eine aggressiv verlaufende Autoimmunerkrankung, die den Kleingefäßvaskulitiden zugeordnet wird und im weiteren Sinn auch als Goodpasture-Syndrom bekannt ist. Sie verläuft entweder auf die Nieren beschränkt (Anti-GBM-Nephritis) oder manifestiert in Form eines pulmorenalen ...
Windpessl, Martin, Kronbichler, Andreas
openaire   +1 more source

Analysis of sentiments on the onset of Covid-19 using Machine Learning Techniques

Advances in Distributed Computing and Artificial Intelligence Journal, 2022
The novel coronavirus (Covid-19) pandemic has struck the whole world and is one of the most striking topics on social media platforms. Sentiment outbreak on social media enduring various thoughts, opinions, and emotions about the Covid-19 disease ...
Vishakha Arya, Amit Kumar Mishra Mishra, Alfonso González-Briones   +2 more
doaj   +1 more source

Circadian regulator CLOCK recruits immune suppressive microglia into the GBM tumor microenvironment.

Cancer Discovery, 2020
Glioblastoma (GBM) is a lethal brain tumor containing a subpopulation of glioma stem cells (GSCs). Pan-cancer analyses have revealed that stemness of cancer cells correlates positively with immunosuppressive pathways in many solid tumors, including GBM ...
Peiwen Chen, Wen-Hao Hsu, Andrew Chang, Zhi Tan, Zhengdao Lan, Ashley Zhou, D. Spring, Frederick F. Lang, Y. A. Wang, Ronald A. DePinho   +9 more
semanticscholar   +1 more source

Comparison of the performance of a chemiluminescence assay and an ELISA for detection of anti-GBM antibodies

Renal Failure, 2020
Objective Autoantibodies to the α3 chain noncollagen 1 domain of type IV collagen (α3(IV)NC1) are a serological hallmark in the diagnosis of anti-glomerular basement membrane (GBM) disease.
Ying Tan, Wei Pang, Xiaoyu Jia, Ming-hui Zhao   +3 more
doaj   +1 more source

Deep Learning Can Differentiate IDH-Mutant from IDH-Wild GBM

Journal of Personalized Medicine, 2021
Isocitrate dehydrogenase (IDH) mutant and wildtype glioblastoma multiforme (GBM) often show overlapping features on magnetic resonance imaging (MRI), representing a diagnostic challenge.
Luca Pasquini, A. Napolitano, Emanuela Tagliente, F. Dellepiane, M. Lucignani, A. Vidiri, Giulio Ranazzi, A. Stoppacciaro, G. Moltoni, Matteo Nicolai, A. Romano, A. Di Napoli, A. Bozzao   +12 more
semanticscholar   +1 more source