Results 71 to 80 of about 244,777 (197)

Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment. [PDF]

, 2019
Ectopic epigenetic mechanisms play important roles in facilitating tumorigenesis. Here, we first demonstrated that ANKDD1A is a functional tumor suppressor gene, especially in the hypoxia microenvironment.
Fan, Li, Feng, Jianbo, Fu, Haijuan, Li, Guiyuan, Li, Peiyao, Liu, Changhong, Liu, Qiang, Liu, Qing, Ren, Xing, She, Xiaoling, Sun, Yingnan, Wu, Minghua, Zhang, Yan, Zhao, Chunhua   +13 more
core   +1 more source

Immune Characteristics of eQTL and Gene Risk Model and the Inhibitory Effect of DCTD and RRAS on Ferroptosis in Glioblastoma

Frontiers in Bioscience-Landmark
Background: Glioblastoma (GBM) is an extremely aggressive brain tumor, marked by restricted therapeutic possibilities and a generally unfavorable prognosis.
Lulin Zhang, Wei Chen, Weibin Huang, Haoling Cheng   +3 more
doaj   +1 more source

Demographic variation in incidence of adult glioma by subtype, United States, 1992-2007

BMC Cancer, 2011
Background We hypothesized that race/ethnic group, sex, age, and/or calendar period variation in adult glioma incidence differs between the two broad subtypes of glioblastoma (GBM) and non-GBM. Primary GBM, which constitute 90-95% of GBM, differ from non-
Darefsky Amy S, Dubrow Robert
doaj   +1 more source

Evidence of an Internal Dissipation Origin for the High-energy Prompt Emission of GRB 170214A

, 2017
The origin of the prompt high-energy ($>100$MeV) emission of Gamma-ray Bursts (GRBs), detected by the Large Area Telescope (LAT) on board the Fermi Gamma-ray Space Telescope, is still under debate, for which both the external shock origin and internal ...
Liu, Ruo-Yu, Tang, Qing-Wen, Wang, Xiang-Yu   +2 more
core   +1 more source

The Role of Insulin Receptor Substrate 4 (IRS4) Protein in the Radiotherapy Response of Glioblastoma Multiforme (GBM) Cells

Pharmata
Objective: To explain the fundamental role of Insulin Receptor Substrate 4 (IRS4) protein in the response of Glioblastoma Multiforme (GBM) cells to radiotherapy.
Gökhan Görgişen, Tahir Çakir, Aysun Arslan   +2 more
doaj   +1 more source

SENP7 inhibits glioblastoma metastasis and invasion by dissociating SUMO2/3 binding to specific target proteins

Open Medicine
The poor surgical efficacy and recurrence of glioblastoma (GBM) are due to its lack of visible infiltrative features. Our bioinformatics study suggests that low expression of small ubiquitin-like modifier (SUMO)-specific protease 7 (SENP7) indicates poor
Zhang Jixing, Zheng Hongshan, Liang Peng
doaj   +1 more source

Verteporfin-Loaded Anisotropic Poly(Beta-Amino Ester)-Based Micelles Demonstrate Brain Cancer-Selective Cytotoxicity and Enhanced Pharmacokinetics

International Journal of Nanomedicine, 2019
James G Shamul,1,2,* Sagar R Shah,1–3,* Jayoung Kim,1,2 Paula Schiapparelli,3 Carla A Vazquez-Ramos,3 Ben J Lee,1,2 Kisha K Patel,1,2 Alyssa Shin,1,2 Alfredo Quinones-Hinojosa,3 Jordan J Green1,2,4–6 1Department of Biomedical Engineering ...
Shamul JG, Shah SR, Kim J, Schiapparelli P, Vazquez-Ramos CA, Lee BJ, Patel KK, Shin A, Quinones-Hinojosa A, Green JJ   +9 more
doaj  

The Fermi view of gamma-ray bursts

, 2011
Since its successful launch in June 2008, the {\it Fermi} Gamma-ray Space Telescope has made important breakthroughs in the understanding of the Gamma-Ray Burst (GRB) phenomemon.
Abdo, Abdo, Abdo, Abdo, Ackermann, Ackermann, Aharonian, Amelino-Camelia, Asano, Atkins, Atkins, Atwood, Band, Bolmont, De Pasquale, Frédéric Piron, Galante, Garczarczyk, Gilmore, Giuliani, Gonzalez, Granot, Guiriec, Guiriec, Hurley, Jacob, McEnery, Medvedev, Meegan, Razzaque, Ryde, Sommer, Toma, Valerie Connaughton   +33 more
core   +1 more source

Aptamer-Conjugated Gold Nanoparticles Targeting Epidermal Growth Factor Receptor Variant III for the Treatment of Glioblastoma

International Journal of Nanomedicine, 2020
Li Peng,1,2,* Yanling Liang,1,* Xinxin Zhong,1 Zhiman Liang,1,2 Yinghong Tian,3 Shuji Li,1 Jingxue Liang,4 Ransheng Wang,4 Yuqi Zhong,4 Yusheng Shi,5 Xingmei Zhang1 1Key Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao ...
Peng L, Liang Y, Zhong X, Liang Z, Tian Y, Li S, Liang J, Wang R, Zhong Y, Shi Y, Zhang X   +10 more
doaj  

Advances in synthetic lethality modalities for glioblastoma multiforme

Open Medicine
Glioblastoma multiforme (GBM) is characterized by a high mortality rate, high resistance to cytotoxic chemotherapy, and radiotherapy due to its highly aggressive nature.
Richard Seidu A.
doaj   +1 more source