Results 61 to 70 of about 233,509 (250)

An independently validated nomogram for isocitrate dehydrogenase-wild-type glioblastoma patient survival. [PDF]

, 2019
BackgroundIn 2016, the World Health Organization reclassified the definition of glioblastoma (GBM), dividing these tumors into isocitrate dehydrogenase (IDH)-wild-type and IDH-mutant GBM, where the vast majority of GBMs are IDH-wild-type.
Barnholtz-Sloan, Jill S, Berger, Mitchel S, Chunduru, Pranathi, Cioffi, Gino, Gittleman, Haley, Molinaro, Annette M, Sloan, Andrew E   +6 more
core   +1 more source

scResponse: A Rank‐Based Method for Identifying Cell States That Contribute to Immunotherapy Response by Single‐Cell Data

Advanced Science, EarlyView.
Although the tumor microenvironment is known to shape immunotherapy response, its key determinants remain elusive, underscoring the critical need for single‐cell resolution analytical frameworks. We present scResponse, an efficient algorithm to quantify single‐cell responses to immunotherapy. By capturing diverse cellular subtypes and states associated
Qi Dong, Haijun Huang, Yuxiu Wang, Bo Jiang, Yuzheng Chen, Huanhuan Xu, Jing Ren, Shengnan Guo, Tianhao Li, Mingjie Zhang, Tianyu Zhai, Wenbo Yang, Kaidong Liu, Cheng Lyu, Jingxuan Kang, Mingshuo Zhang, Yupeng Lu, Binghui Si, Shujun Cao, Dandan Xu, Zong Chen, Dapeng Hao   +21 more
wiley   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Fermi observations of high-energy gamma-ray emission from GRB 090217A

, 2010
The Fermi observatory is advancing our knowledge of Gamma-Ray Bursts (GRBs) through pioneering observations at high energies, covering more than 7 decades in energy with the two on-board detectors, the Large Area Telescope (LAT) and the Gamma-ray Burst ...
Ackermann, M., Ajello, M., Baldini, L., Ballet, J., Barbiellini, G., Baring, M., Bastieri, D., Bechtol, K., Bellazzini, R., Berenji, B., Bhat, P., Bissaldi, E., Blandford, R., Bonamente, E., Borgland, A., Bouvier, A., Bregeon, J., Brez, A., Briggs, M., Brigida, M., Bruel, P., Buehler, R., Buson, S., Caliandro, G., Cameron, R., Caraveo, P., Carrigan, S., Casandjian, J., Cecchi, C., Charles, E., Chekhtman, A., Chiang, J., Ciprini, S., Claus, R., Cohen-Tanugi, J., Connaughton, V., Conrad, J., Cutini, S., de Angelis, A., de Palma, F., Dermer, C., Digel, S., do Couto e Silva, E., Drell, P., Dubois, R., Favuzzi, C., Fegan, S., Ferrara, E., Frailis, M., Fukazawa, Y., Fusco, P., Gargano, F., Gasparrini, D., Gehrels, N., Germani, S., Giglietto, N., Giommi, P., Giordano, F., Giroletti, M., Glanzman, T., Godfrey, G., Granot, J., Grenier, I., Grove, J., Guillemot, L., Guiriec, S., Hadasch, D., Hays, E., Horan, D., Hughes, R., Johnson, A., Johnson, W., Jóhannesson, G., Kamae, T., Katagiri, H., Kippen, R., Knödlseder, J., Kocevski, D., Kuss, M., Lande, J., Latronico, L., Lee, S., Llena Garde, M., Longo, F., Loparco, F., Lovellette, M., Lubrano, P., Makeev, A., Mazziotta, M., McBreen, S., McEnery, J., McGlynn, S., Meegan, C., Mehault, J., Michelson, P., Mizuno, T., Moiseev, A., Monte, C., Monzani, M., Moretti, E., Morselli, A., Moskalenko, I., Murgia, S., Mészáros, P., Nakajima, H., Nakamori, T., Naumann-Godo, M., Nolan, P., Norris, J., Nuss, E., Ohno, M., Ohsugi, T., Okumura, A., Omodei, N., Orlando, E., Ormes, J., Ozaki, M., Paciesas, W., Paneque, D., Panetta, J., Parent, D., Pelassa, V., Pepe, M., Pesce-Rollins, M., Petrosian, V., Piron, F., Porter, T., Preece, R., Racusin, J., Rainò, S., Rando, R., Rau, A., Razzano, M., Razzaque, S., Reimer, A., Reimer, O., Ripken, J., Roth, M., Ryde, F., Sadrozinski, H., Sander, A., Scargle, J., Schalk, T., Sgrò, C., Siskind, E., Smith, P., Spandre, G., Spinelli, P., Stamatikos, M., Strickman, M., Suson, D., Tajima, H., Takahashi, H., Tanaka, T., Thayer, J., Thayer, J., Tibaldo, L., Torres, D., Tosti, G., Tramacere, A., Uehara, T., Usher, T., van der Horst, A., Vandenbroucke, J., Vasileiou, V., Vilchez, N., Vitale, V., von Kienlin, A., Waite, A., Wang, P., Wilson-Hodge, C., Winer, B., Wood, K., Wu, X., Yamazaki, R., Yang, Z., Ylinen, T., Ziegler, M., Çelik, Ö.   +178 more
core   +3 more sources

A Solution for Exosome‐Based Analysis: Surface‐Enhanced Raman Spectroscopy and Artificial Intelligence

Advanced Intelligent Discovery, EarlyView.
Exosomes are emerging as powerful biomarkers for disease diagnosis and monitoring. This review highlights the integration of surface‐enhanced Raman spectroscopy with artificial intelligence to enhance molecular fingerprinting of exosomes. Machine learning and deep learning techniques improve spectral interpretation, enabling accurate classification of ...
Munevver Akdeniz, Zakarya Al‐Shaebi, Omer Aydin   +2 more
wiley   +1 more source

Anomalies in low-energy Gamma-Ray Burst spectra with the Fermi Gamma-Ray Burst Monitor

, 2013
A Band function has become the standard spectral function used to describe the prompt emission spectra of gamma-ray bursts (GRBs). However, deviations from this function have previously been observed in GRBs detected by BATSE and in individual GRBs from ...
Bissaldi, Elisabetta, Briggs, Michael S., Burgess, J. Michael, Connaughton, Valerie, Fitzpatrick, Gerard, Foley, Suzanne, Goldstein, Adam, Greiner, Jochen, Gruber, David, Guiriec, Sylvain, Kouveliotou, Chryssa, McBreen, Sheila, McGlynn, Sinead, Paciesas, William S., Pelassa, Veronique, Preece, Robert D., Tierney, Dave, von Kienlin, Andreas   +17 more
core   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Harnessing Machine Learning to Understand and Design Disordered Solids

Advanced Intelligent Discovery, EarlyView.
This review maps the dynamic evolution of machine learning in disordered solids, from structural representations to generative modeling. It explores how deep learning and model explainability transform property prediction into profound physical insight.
Muchen Wang, Yue Fan
wiley   +1 more source

Short Gamma-Ray Bursts with Extended Emission Observed with Swift/BAT and Fermi/GBM

, 2015
Some short GRBs are followed by longer extended emission, lasting anywhere from ~10 to ~100 s. These short GRBs with extended emission (EE) can possess observational characteristics of both short and long GRBs (as represented by GRB 060614), and the ...
Bostanci, Z. F., Gogus, E., Kaneko, Y., Lin, L.   +3 more
core   +1 more source

The Homozygous p.(Arg215Ter) Variant in XRCC2 Is Associated With Atypical Fanconi Anemia Without Major Hematological Abnormalities in Childhood

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Fanconi Anemia (FA) is the most frequent inherited bone marrow failure syndrome. A role for the XRCC2 gene in FA was suspected in 2012 and confirmed in 2016, but only two affected individuals have been described thus far, and no long‐term follow‐up is available.
Sabina Cenciarelli, Giulia Bruna Marchetti, Maria Iascone, Maria Grazia Patricelli, Sara Giangiobbe, Gabriella Cinzia Pozzobon, Miriam Nella Savini, Fabio Giglio, Alessandro Aiuti, Paola Carrera, Francesca Ferrua, Angela Peron   +11 more
wiley   +1 more source