Results 51 to 60 of about 204,238 (313)

The fermi view of gamma-ray bursts at the dawn of the multi-messenger era

, 2019
Gamma-Ray Bursts (GRBs) are among the most powerful astrophysical phenomena. Recent observations are shedding light into their high-energy emission properties. Here I will review GRB observations made by the Fermi instruments, the Gamma-Ray Burst Monitor
Fermi-LAT Collaborations, the Fermi-GBM, Elisabetta Bissaldi   +2 more
core   +1 more source

TCGA-GBM.

, 2021
Sample metadata information for TCGA-GBM samples used in CSV format. (CSV)
Siddharth Jain (267351), Jehoshua Bruck (6309647), Netanel Raviv (11408504), Bijan Mazaheri (11408501)   +3 more
core   +1 more source

TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM

OncoImmunology, 2018
The use of inhibitory checkpoint blockade in the management of glioblastoma has been studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently discovered to play a role in cancer immunity.
Alice L. Hung, Russell Maxwell, Debebe Theodros, Zineb Belcaid, Dimitrios Mathios, Andrew S. Luksik, Eileen Kim, Adela Wu, Yuanxuan Xia, Tomas Garzon-Muvdi, Christopher Jackson, Xiaobu Ye, Betty Tyler, Mark Selby, Alan Korman, Bryan Barnhart, Su-Myeong Park, Je-In Youn, Tamrin Chowdhury, Chul-Kee Park, Henry Brem, Drew M. Pardoll, Michael Lim   +22 more
doaj   +1 more source

The 52 Brightest and Hardest GRBs Detected with the Gamma-ray Burst Monitor on Fermi

, 2011
We present our results of the temporal and spectral analysis of a sample of 52 bright and hard gamma-ray bursts (GRBs) observed with the Fermi Gamma-ray Burst Monitor (GBM) during its first year of operation (July 2008-July 2009). Our sample was selected
The Fermi GBM Team, BISSALDI, ELISABETTA
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Insight into the Progress in CAR-T Cell Therapy and Combination with Other Therapies for Glioblastoma

International Journal of General Medicine, 2023
Tingyu Liang,* Yixuan Song,* Lingui Gu, Yu Wang, Wenbin Ma Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These ...
Liang T, Song Y, Gu L, Wang Y, Ma W
doaj  

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Vortioxetine exhibits anti-glioblastoma activity via the PI3K-Akt signaling pathway [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Glioblastoma multiforme (GBM) presents a significant challenge in oncology due to its highly aggressive nature and inherent resistance to conventional therapeutic interventions.
Huan-Qi Zhang, Dao-Ming Zhang, Zhi-Zhen Huang, Jing Cheng, Chong Zhang, Neng-Ming Lin, Yang-Ling Li   +6 more
doaj   +1 more source

Targeted Molecular Therapy of GBM

Brain Pathology, 2003
Major advances in molecular biology, cellular biology and genomics have substantially improved our understanding of cancer. Now, these advances are being translated into therapy. Targeted therapy directed at specific molecular alterations is already creating a shift in the treatment of cancer patients.
Paul S, Mischel, Timothy F, Cloughesy
openaire   +3 more sources