Results 1 to 10 of about 521,325 (180)
Revisiting the role of the Gcm transcription factor, from master regulator to Swiss army knife [PDF]
Fly, 2016 Master genes are known to induce the differentiation of a multipotent cell into a specific cell type. These molecules are often transcription factors that switch on the regulatory cascade that triggers cell specification. Gcm was first described as the master gene of the glial fate in Drosophila as it induces the differentiation of neuroblasts into ...
Pierre B. Cattenoz, Angela Giangrande
semanticscholar +5 more sources
Neurogenic role of Gcm transcription factors is conserved in chicken spinal cord [PDF]
Development, 2007 Although glial cells missing (gcm) genes are known as glial determinants in the fly embryo, the role of vertebrate orthologs in the central nervous system is still under debate. Here we show for the first time that the chicken ortholog of fly gcm (herein referred to as c-Gcm1), is expressed in early neuronal lineages of the developing spinal cord and ...
Laurent Soustelle +6 more
semanticscholar +6 more sources
Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function [PDF]
Scientific Reports, 2023 In bilaterian central nervous systems, coordination of neurotransmission by glial cells enables highly sophisticated neural functions. The diversity of transcription factors (TFs) involved in gliogenesis suggests multiple evolutionary origins of various ...
Larisa Sheloukhova, Hiroshi Watanabe
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Polycomb controls gliogenesis by regulating the transient expression of the Gcm/Glide fate determinant. [PDF]
PLoS Genetics, 2012 The Gcm/Glide transcription factor is transiently expressed and required in the Drosophila nervous system. Threshold Gcm/Glide levels control the glial versus neuronal fate choice, and its perdurance triggers excessive gliogenesis, showing that its tight
Anna Popkova +8 more
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A transcription factor glial cell missing (Gcm) in the freshwater crayfish Pacifastacus leniusculus
Developmental & Comparative Immunology, 2020 The transcription factor glial cell missing, Gcm, is known to be an important protein in the determination of glial cell fate as well as embryonic plasmatocyte differentiation in Drosophila melanogaster. So far, no function for Gcm in crustaceans has been reported.
Kingkamon Junkunlo +2 more
semanticscholar +6 more sources
Scientific Reports, 2016 AbstractNR5A1 is essential for the development and for the function of steroid producing glands of the reproductive system. Moreover, its misregulation is associated with endometriosis, which is the first cause of infertility in women. Hr39, the Drosophila ortholog of NR5A1, is expressed and required in the secretory cells of the spermatheca, the ...
Pierre B. Cattenoz +3 more
semanticscholar +6 more sources
Functional Conservation of the Glide/Gcm Regulatory Network Controlling Glia, Hemocyte, and Tendon Cell Differentiation in Drosophila. [PDF]
Genetics, 2015 High-throughput screens allow us to understand how transcription factors trigger developmental processes, including cell specification. A major challenge is identification of their binding sites because feedback loops and homeostatic interactions may ...
Aiello, Giuseppe +5 more
core +7 more sources
, 2014 Cell fate determination involves key transcription factors. ln Drosophila, the transcription factor Glide/Gcm is required for the differentiation of two immune cell types: circulating macrophages,which arise from hematopoietic precursors, and glial cells, resident macrophages of the central nervous system, which differentiate from neural precursors. ln
Guillaume Trébuchet
openalex +3 more sources
Horticulturae, 2023 Broccoli (Brassica oleracea L. var. italica) has a large, edible green flower head, which is one of its critical economic traits. A prerequisite of broccoli flower head formation is flower bud differentiation (FBD).
Wenchen Chai +10 more
doaj +1 more source
Impacts of a new transcription factor family [PDF]
The Journal of Cell Biology, 2004 GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila ...
Michael Wegner, Said Hashemolhosseini
openaire +3 more sources