KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]
, 2016 Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M +11 more
core +7 more sources
Genomic control of patterning [PDF]
, 2009 The development of multicellular organisms involves the partitioning of the organism into territories of cells of specific structure and function. The information for spatial patterning processes is directly encoded in the genome.
Davidson, Eric H., Peter, Isabelle S.
core +2 more sources
Evolutionary plasticity of developmental gene regulatory network architecture [PDF]
, 2007 Sea stars and sea urchins evolved from a last common ancestor that lived at the end of the Cambrian, approximately half a billion years ago. In a previous comparative study of the gene regulatory networks (GRNs) that embody the genomic program for ...
Britten +25 more
core +4 more sources
Isolation of pigment cell specific genes in the sea urchin embryo by differential macroarray screening [PDF]
, 2003 New secondary mesenchyme specific genes, expressed exclusively in pigment cells, were isolated from sea urchin embryos using a differential screening of a macroarray cDNA library. The comparison was performed between mRNA populations of embryos having an
Calestani, Cristina +2 more
core +1 more source
Gcm proteins function in the developing nervous system [PDF]
, 2012 A fundamental issue during nervous system development is how individual cells are formed from the undefined precursors. Differentiated neurons and glia, two major cell types mediating neuronal function, are acquired from immature precursors via a series ...
Mao, Haian +2 more
core +1 more source
Drosophila GATA Factor Serpent Establishes Phagocytic Ability of Embryonic Macrophages
Frontiers in Immunology, 2018 During Drosophila embryogenesis, a large number of apoptotic cells are efficiently engulfed and degraded by professional phagocytes, macrophages. Phagocytic receptors Six-Microns-Under (SIMU), Draper (Drpr) and Croquemort (Crq) are specifically expressed
Evgeny Shlyakhover +5 more
doaj +1 more source
CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]
, 2018 Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio +6 more
core +1 more source
Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo [PDF]
, 2008 We dissect the transcriptional regulatory relationships coordinating the dynamic expression patterns of two signaling genes, wnt8 and delta, which are central to specification of the sea urchin embryo endomesoderm.
Alifragis +34 more
core +3 more sources
Scientific Reports, 2017 The placental transcription factors Distal-less 3 (DLX3) and Glial cell missing-1 (GCM1) have been shown to coordinate the specific regulation of PGF in human trophoblast cell lines.
Sha Li, Mark S. Roberson
doaj +1 more source
Properties of developmental gene regulatory networks [PDF]
, 2008 The modular components, or subcircuits, of developmental gene regulatory networks (GRNs) execute specific developmental functions, such as the specification of cell identity.
Davidson, Eric H., Levine, Michael S.
core +2 more sources