Impacts of a new transcription factor family: mammalian GCM proteins in health and disease.
The Journal of cell biology, 2004 GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila ...
Hashemolhosseini, Said, Wegner, Michael
openaire +2 more sources
High accuracy, high-resolution prevalence measurement for the majority of locally expressed regulatory genes in early sea urchin development [PDF]
, 2010 Accurate measurements of transcript abundance are a prerequisite to understand gene activity in development. Using the NanoString nCounter, an RNA counting device, we measured the prevalence of 172 transcription factors and signaling molecules in early ...
Davidson, Eric H. +2 more
core +1 more source
Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
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Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology [PDF]
, 2009 Gene regulatory networks (GRNs) for development underlie cell fate specification and differentiation. Network topology, logic, and dynamics can be obtained by thorough experimental analysis.
Ben-Tabou de-Leon, Smadar +1 more
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Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]
, 2013 Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C +8 more
core +6 more sources
Logic of gene regulatory networks [PDF]
, 2007 Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward.
Davidson, Eric H., Materna, Stefan C.
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MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brain [PDF]
, 2014 Glia are abundant cells in the brain of animals ranging from flies to humans. They perform conserved functions not only in neural development and wiring, but also in brain homeostasis.
Heino, Tapio, Stratoulias, Vassilis
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The Application of RNA Interference to Knock Out Groucho Expression in Drosophila S2 Cells [PDF]
, 2016 The development of a complex nervous system requires the actions of intricate genetic mechanisms that influence and maintain the differentiation of common nervous system progenitor cells into neurons and glial cells. In Drosophila melanogaster, the gene
Mitchell, Savannah
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Definition of Drosophila hemocyte subsets by cell-type specific antigens. [PDF]
, 2007 We analyzed the heterogeneity of Drosophila hemocytes on the basis of the expression of cell-type specific antigens. The antigens characterize distinct subsets which partially overlap with those defined by morphological criteria.
Andó, István +9 more
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Building developmental gene regulatory networks [PDF]
, 2009 Animal development is an elaborate process programmed by genomic regulatory instructions. Regulatory genes encode transcription factors and signal molecules, and their expression is under the control of cis-regulatory modules that define the logic of ...
Davidson, Eric H., Li, Enhu
core +1 more source