The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS [PDF]
, 2003 The Drosophila dead ringer (dri, also known as retained, retn) gene encodes a nuclear protein with a conserved DNA-binding domain termed the ARID (AT-rich interaction domain).
Saint, R., Shandala, T., Takizawa, K.
core +1 more source
Impacts of a new transcription factor family: mammalian GCM proteins in health and disease.
The Journal of cell biology, 2004 GCM proteins constitute a small transcription factor family with a DNA-binding domain exhibiting a novel fold composed of two subdomains rigidly held together by coordination of one of two structural zinc cations. In all known cases, GCM proteins exert the role of master regulators: the prototypical family member determines gliogenesis in Drosophila ...
Hashemolhosseini, Said, Wegner, Michael
openaire +2 more sources
High accuracy, high-resolution prevalence measurement for the majority of locally expressed regulatory genes in early sea urchin development [PDF]
, 2010 Accurate measurements of transcript abundance are a prerequisite to understand gene activity in development. Using the NanoString nCounter, an RNA counting device, we measured the prevalence of 172 transcription factors and signaling molecules in early ...
Davidson, Eric H. +2 more
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Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
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Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology [PDF]
, 2009 Gene regulatory networks (GRNs) for development underlie cell fate specification and differentiation. Network topology, logic, and dynamics can be obtained by thorough experimental analysis.
Ben-Tabou de-Leon, Smadar +1 more
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Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]
, 2013 Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C +8 more
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Logic of gene regulatory networks [PDF]
, 2007 Regulatory networks of transcription factors and signaling molecules lie at the heart of development. Their architecture implements logic functions whose execution propels cells from one regulatory state to the next, thus driving development forward.
Davidson, Eric H., Materna, Stefan C.
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MANF silencing, immunity induction or autophagy trigger an unusual cell type in metamorphosing Drosophila brain [PDF]
, 2014 Glia are abundant cells in the brain of animals ranging from flies to humans. They perform conserved functions not only in neural development and wiring, but also in brain homeostasis.
Heino, Tapio, Stratoulias, Vassilis
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Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages
Advanced Science, EarlyView.Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu +14 more
wiley +1 more source
Unlocking fruit dimensions: Quantification of functional traits driving plant–frugivore interactions
Applications in Plant Sciences, EarlyView.Abstract Fleshy fruits attract animals to ingest fruit, swallow the seeds, and release them in the landscape, thus facilitating seed dispersal and plant regeneration. Attraction of animal dispersers is achieved via attractants such as color or scent, and rewards like sugars, lipids, and micronutrients.
Linh M. N. Nguyen +4 more
wiley +1 more source