Results 31 to 40 of about 4,419 (127)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Unlocking fruit dimensions: Quantification of functional traits driving plant–frugivore interactions

Applications in Plant Sciences, EarlyView.
Abstract Fleshy fruits attract animals to ingest fruit, swallow the seeds, and release them in the landscape, thus facilitating seed dispersal and plant regeneration. Attraction of animal dispersers is achieved via attractants such as color or scent, and rewards like sugars, lipids, and micronutrients.
Linh M. N. Nguyen, Evangelia Linda Chronopoulou, Gabriela A. S. Escaliante, Kim Valenta, Omer Nevo   +4 more
wiley   +1 more source

Future Range Shifts and Diversity Patterns of Antarctic Lecideoid Lichens Under Climate Change Scenarios

Global Change Biology Communications, EarlyView.
Modeling of current and future spatial distribution of Antarctic lecideoid lichens shows that warming will strongly increase the potential habitat. Under three climate‐change scenarios, most fungal and algal partners are projected to expand inland. Overall, climate change drives widespread range shifts and promotes colonization of interior Antarctica ...
Anna Götz, Mikhail Andreev, Robert R. Junker, Lea Maislinger, Leopoldo G. Sancho, Wolfgang Trutschnig, Ulrike Ruprecht   +6 more
wiley   +1 more source

Quality of Dying Among Institutionalised Nursing Home Residents From the Caregivers' Perspective: A Mixed‐Methods Study

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aims To examine how family caregivers of deceased nursing home residents scored and justified their ratings for each item on the Quality of Dying in Long‐Term Care scale and to identify the consistencies and discrepancies between their perceptions and the scores assigned when assessing the residents' end‐of‐life experience. Design A convergent
Daniel Puente‐Fernandez, Emilio Mota‐Romero, Manuel Fernández‐Alcántara, María Paz Garcia‐Caro, Concepción Roldán, Rafael Montoya‐Juarez   +5 more
wiley   +1 more source

Evolutionary Conserved and Divergent Responses to Copper Zinc Superoxide Dismutase Inhibition in Plants

Plant, Cell &Environment, EarlyView.
ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn, Fabian B. Haas, Benjamin G. Chavez, Bernd H. Dreyer, Erik V. Reiss, Anne Ziplys, Heiko Weichert, Saskia Hiltemann, José M. Ugalde, Andreas J. Meyer, John C. D'Auria, Stefan A. Rensing, Jos H. M. Schippers   +12 more
wiley   +1 more source

Effects of Elevated CO2 on Bean Pod Mottle Virus Infection in Both Incompatible and Compatible Interactions With Phaseolus vulgaris L

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant viruses cause significant crop losses, a situation that could worsen due to anthropogenic activities driving global climate change, one factor of which is the increase in atmospheric CO2 concentration. This study assessed the impact of elevated CO2 concentration (eCO2, 1000 vs. 400 ppm) on two genotypes of common bean (Phaseolus vulgaris
Tiffanie Scandolera, Julie Lintz, Ariane Gratias, Ellea Aboud, Simon Rochoux, Maria V. Préjean, Gilles Chatel Innocenti, Marie Garmier, Gianluca Teano, Juan C. Alvarez‐Diaz, Graham Noctor, Valérie Geffroy, Stéphanie Pflieger   +12 more
wiley   +1 more source

Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice

Experimental Physiology, EarlyView.
Abstract This study investigated whether performing a translatable murine model of concurrent training after tumour induction affects adaptations in juvenile male and female tumour‐bearing mice. Male and female Balb/c mice were injected bilaterally with colon‐26 adenocarcinoma (C26) cells or PBS at 8 weeks of age.
Stavroula Tsitkanou, Pieter Koopmans, Calvin Peterson, Ana Regina Cabrera, Ruqaiza Muhyudin, Francielly Morena, Sabin Khadgi, Eleanor R. Schrems, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +10 more
wiley   +1 more source

When Metabolomics Meets Quantitative Genetics: An Integrative Strategy to Elucidate Plant Resistance Mechanisms

Plant, Cell &Environment, Volume 49, Issue 3, Page 1712-1727, March 2026.
ABSTRACT Gene pyramiding in crop varieties offers a promising strategy to achieve sustainable production and reduce reliance on pesticides. However, stacking resistance genes without understanding their biological functions may result in transient protection.
Romane Lapous, Komla Exonam Amegan, Bernard Caromel, Charles‐Eric Durel, Anne‐Violette Lavoir, Julie Ferreira de Carvalho, Romain Larbat   +6 more
wiley   +1 more source

Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development

Biotechnology and Bioengineering, Volume 123, Issue 2, Page 363-378, February 2026.
The authors report the development of a controlled and scalable 3D co‐culture system combining hiPSC‐derived erythromyeloid progenitors and neurospheres within the Ambr® 250 Modular platform operated with a newly designed perfusion system. This model faithfully recapitulates early microglia–neural interactions, enabling progenitor integration ...
Catarina M. Gomes, Inês de Sá, Margarida Delgado, Paula M. Alves, Catarina Brito   +4 more
wiley   +1 more source

Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter [PDF]

, 2018
Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-subunit
Anson-Cartwright, Antczak, Baczyk, Baczyk, Bainbridge, Ben Jebara, Cabrera-Sharp, Cheong, Combarnous, Daels, de Mestre, de Mestre, De Rensis, Jolma, Jones, Kanemura, Kim, Lelli, Pfaffl, Saint-Dizier, Schubert, Sherman, Stefanetti, Stewart, Stewart, Sugino, Wilsher, Wolfe, Yamada, Yu   +29 more
core   +4 more sources