The Application of RNA Interference to Knock Out Groucho Expression in Drosophila S2 Cells [PDF]
The development of a complex nervous system requires the actions of intricate genetic mechanisms that influence and maintain the differentiation of common nervous system progenitor cells into neurons and glial cells. In Drosophila melanogaster, the gene
Mitchell, Savannah
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Glial Cells Missing 1 Regulates Equine Chorionic Gonadotrophin Beta Subunit via Binding to the Proximal Promoter [PDF]
Equine chorionic gonadotrophin (eCG) is a placental glycoprotein critical for early equine pregnancy and used therapeutically in a number of species to support reproductive activity. The factors in trophoblast that transcriptionally regulate eCGβ-subunit
Anson-Cartwright+29 more
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Expanding the Genetic and Phenotypic Spectrum of POLRMT‐Related Mitochondrial Disease
We identified potentially damaging monoallelic and biallelic POLRMT variants in affected individuals from six unrelated families, thus extending both the clinical and genetic phenotypes of POLRMT‐related mitochondrial disease. ABSTRACT Mitochondrial diseases are a complex group of conditions exhibiting significant phenotypic and genetic heterogeneity ...
Mahmoud R. Fassad+20 more
wiley +1 more source
The dead ringer/retained transcriptional regulatory gene is required for positioning of the longitudinal glia in the Drosophila embryonic CNS [PDF]
The Drosophila dead ringer (dri, also known as retained, retn) gene encodes a nuclear protein with a conserved DNA-binding domain termed the ARID (AT-rich interaction domain).
Saint, R., Shandala, T., Takizawa, K.
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Abstract Sexual maturation in many fishes requires a major physiological change that involves a rapid transition between energy storage and usage. In Atlantic salmon, this transition for the initiation of maturation is tightly controlled by seasonality and requires a high‐energy status.
Ehsan Pashay Ahi+7 more
wiley +1 more source
High accuracy, high-resolution prevalence measurement for the majority of locally expressed regulatory genes in early sea urchin development [PDF]
Accurate measurements of transcript abundance are a prerequisite to understand gene activity in development. Using the NanoString nCounter, an RNA counting device, we measured the prevalence of 172 transcription factors and signaling molecules in early ...
Davidson, Eric H.+2 more
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ABSTRACT After an initial evolution in a reducing environment, life got successively challenged by reactive oxygen species (ROS), especially during the great oxidation event (GOE) that followed the development of photosynthesis. Therefore, ROS are deeply intertwined into the physiological, morphological and transcriptional responses of most present‐day
Stephanie Frohn+12 more
wiley +1 more source
Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology [PDF]
Gene regulatory networks (GRNs) for development underlie cell fate specification and differentiation. Network topology, logic, and dynamics can be obtained by thorough experimental analysis.
Ben-Tabou de-Leon, Smadar+1 more
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Plastids in a Pinch: Coordinating Stress and Developmental Responses Through Retrograde Signalling
ABSTRACT Plastids are crucial for fuelling and regulating plant growth and development. Photosynthesising chloroplasts provide energy for growth, while other plastids play additional key roles in various aspects of plant physiology. For function and development, plastids greatly depend on nucleus‐encoded proteins, and they can modulate the synthesis of
Elizabeth van Veen+2 more
wiley +1 more source
Gliogenesis Depends on glide/gcm through Asymmetric Division of Neuroglioblasts [PDF]
Some neurons and glial cells originate from neuroblasts and glioblasts, stem cells that delaminate from the ectoderm of developing fly embryos. A second class of glial cells and neurons differentiates from multipotent precursors, the neuroglioblasts. The
Bernardoni, Roberto+3 more
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