Results 41 to 50 of about 521,325 (180)

Myocellular adaptations to short‐term weighted wheel‐running exercise are largely conserved during C26‐tumour induction in male and female mice

Experimental Physiology, EarlyView.
Abstract This study investigated whether performing a translatable murine model of concurrent training after tumour induction affects adaptations in juvenile male and female tumour‐bearing mice. Male and female Balb/c mice were injected bilaterally with colon‐26 adenocarcinoma (C26) cells or PBS at 8 weeks of age.
Stavroula Tsitkanou, Pieter Koopmans, Calvin Peterson, Ana Regina Cabrera, Ruqaiza Muhyudin, Francielly Morena, Sabin Khadgi, Eleanor R. Schrems, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene   +10 more
wiley   +1 more source

Protection by glia-conditioned medium in a cell model of Huntington disease

PLOS Currents, 2012
The physiological role of huntingtin and the pathogenic mechanisms that produce the disease are unknown. Mutant huntingtin changes its normal localization and produces cytoplasmic and intranuclear inclusions, changes gene transcription, alters synaptic ...
C. Ruíz, M. Casarejos, A. Gómez, R. Solano, J. D. de Yébenes, M. Mena   +5 more
semanticscholar   +1 more source

Landscape transcriptomics as a tool for addressing global change effects across diverse species

Molecular Ecology Resources, Volume 25, Issue 5, July 2025.
Abstract Landscape transcriptomics is an emerging field studying how genome‐wide expression patterns reflect dynamic landscape‐scale environmental drivers, including habitat, weather, climate, and contaminants, and the subsequent effects on organismal function. This field is benefitting from advancing and increasingly accessible molecular technologies,
Jason Keagy, Chloe P. Drummond, Kadeem J. Gilbert, Christina M. Grozinger, Jill Hamilton, Heather M. Hines, Jesse Lasky, Cheryl A. Logan, Ruairidh Sawers, Tyler Wagner   +9 more
wiley   +1 more source

The Repo homeodomain transcription factor suppresses hematopoiesis in Drosophila and preserves the glial fate [PDF]

, 2019
Despite their different origins, Drosophila glia and hemocytes are related cell populations that provide an immune function. Drosophila hemocytes patrol the body cavity and act as macrophages outside the nervous system whereas glia originate from the ...
Cattenoz, Pierre, Fanto, Manolis, Giangrande, Angela, Manolis, X, Mazaud, David, Siekhaus, Daria,, Trebuchet, Guillaume, Zsámboki, János   +7 more
core   +4 more sources

Evolution and expression of Glial Cells Missing (GCM1 and GCM2) in monotremes suggests an ancient role in reproduction and placentation

bioRxiv
The Glial Cells Missing (GCM) genes were first discovered in Drosophila and encode transcription factors important for gliogenesis. In placental mammals, GCM1 regulates several genes that are important for early placenta development, while its paralog ...
Isabella Wilson, D. Hamdan, Frank Grützner   +2 more
semanticscholar   +1 more source

FBW2 Targets GCMa to the Ubiquitin-Proteasome Degradation System*

Journal of Biological Chemistry, 2005
The GCM proteins GCMa/1 and GCMb/2 are novel zinc-containing transcription factors critical for glial cell differentiation in fly and for placental as well as parathyroid gland development in mouse.
Chih-Sheng Yang, Chenchou Yu, H. Chuang, Ching-Wen Chang, G. Chang, T. Yao, Hungwen Chen   +6 more
semanticscholar   +1 more source

Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]

, 2017
In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J., Gilmore, Thomas D., Matthews, Bryan J., Messerschmidt, Jonathan L., Reynoso, Marinaliz, Williams, Leah M.   +5 more
core   +1 more source

Protein Stability and Domain Topology Determine the Transcriptional Activity of the Mammalian Glial Cells Missing Homolog, GCMb*

Journal of Biological Chemistry, 2000
The glial cells missing (GCM) family of transcription factors consists of Drosophila GCM and the mammalian proteins GCMa and GCMb. They are expressed in a highly restricted manner during development and are known or assumed to be important regulators of ...
E. Tuerk, J. Schreiber, M. Wegner
semanticscholar   +1 more source

A novel role of the glial fate determinant glial cells missing in hematopoiesis.

International Journal of Developmental Biology, 2009
Glial cell deficient/Glial cells missing (Glide/Gcm) transcription factor is expressed in all glial precursors of the Drosophila embryo. Gcm is necessary and sufficient to induce glial differentiation but also plays a role in other cell types, by ...
Cécile Jacques, L. Soustelle, I. Nagy, Céline Diebold, A. Giangrande   +4 more
semanticscholar   +1 more source

Nanomaterials for enhanced X‐ray‐triggered cancer therapy: Progress and prospects

BMEMat, Volume 3, Issue 2, June 2025.
This review summarizes the latest progress in nanomaterials for X‐ray‐triggered cancer therapy, highlighting their various advantages such as targeted delivery, reduced side effects, and enhanced therapeutic efficacy. Abstract X‐rays, a form of ionizing radiation with high energy and significant penetration capability, are commonly used in clinical ...
Yuanchun Chen, Shijie Shangguan, Zhongyu Lin, Xuemei Zeng, Siew Yin Chan, Xian Qin, Shuangqian Yan   +6 more
wiley   +1 more source