Results 61 to 70 of about 521,325 (180)

Autoregulation of the Glial Gene Reversed Polarity in Drosophila Melanogaster [PDF]

, 2017
Autoregulation is the process where an encoded protein is able to bind to and positively or negatively regulate its own expression. Autoregulatory loops are crucial for sustained gene expression, and such loops have been demonstrated to be important for ...
Suiter, Chase
core   +1 more source

An ancient role for Gata-1/2/3 and Scl transcription factor homologs in the development of immunocytes [PDF]

, 2013
Although vertebrate hematopoiesis is the focus of intense study, immunocyte development is well-characterized in only a few invertebrate groups. The sea urchin embryo provides a morphologically simple model for immune cell development in an organism that
Ho, Eric C.H., Loza-Coll, Mariano, Oliveri, Paola, Rast, Jonathan P., Schrankel, Catherine S., Solek, Cynthia M., Wang, Guizhi   +6 more
core   +1 more source

Activating AMPK improves pathological phenotypes due to mtDNA depletion

The FEBS Journal, Volume 292, Issue 9, Page 2359-2380, May 2025.
In a cellular model of mitochondrial disease characterized by progressive mitochondrial DNA (mtDNA) depletion, we found that advancing mitochondrial dysfunction triggers the early and specific activation of the mitochondria‐associated pool of AMP‐activated protein kinase (AMPK), a master regulator of energy homeostasis.
Gustavo Carvalho, Tran V. H. Nguyen, Bruno Repolês, Josefin M. E. Forslund, W. M. Ruchitha Rukmal Wijethunga, Farahnaz Ranjbarian, Isabela C. Mendes, Choco Michael Gorospe, Namrata Chaudhari, Micol Falabella, Mara Doimo, Sjoerd Wanrooij, Robert D. S. Pitceathly, Anders Hofer, Paulina H. Wanrooij   +14 more
wiley   +1 more source

Muscle plasticity related to changes in tubulin and αB-crystallin levels induced by eccentric contraction in rat skeletal muscles [PDF]

, 2016
We used the model of eccentric contraction of the hindlimb muscle by Ochi et al. to examine the role of eccentric contraction in muscle plasticity. This model aims to focus on stimulated skeletal muscle responses by measuring tissue weights and tracing ...
Hatta, H, Jee, H, Lim, J-Y, Nakazato, K, Ochi, E, Sakurai, T   +5 more
core   +1 more source

Nr4a transcription factors limit CAR T cell function in solid tumors

Nature, 2019
T cells expressing chimeric antigen receptors (CAR T cells) targeting human CD19 (hCD19) have shown clinical efficacy against B cell malignancies1,2.
Joyce Chen, Isaac F. López-Moyado, Hyungseok Seo, C. Lio, Laura J. Hempleman, T. Sekiya, A. Yoshimura, J. Scott-Browne, A. Rao   +8 more
semanticscholar   +1 more source

Unveiling the Impact of Vernalisation on Seed Oil Content and Fatty Acid Composition in Rapeseed (Brassica napus L.) Through Simulated Shorter Winters

Journal of Agronomy and Crop Science, Volume 211, Issue 3, May 2025.
ABSTRACT Climate change is leading to warmer winters world‐wide with an increasing number of extreme events every year. Studies show that winter varieties of rapeseed are particularly impacted negatively by global warming. This study investigates the molecular, physiological, and biochemical effects of diverse vernalisation scenarios (i.e., the ...
İrem Çağlı, Büşra Elif Kıvrak, Osman Altunbaş, Çağla Sönmez   +3 more
wiley   +1 more source

Short Exposure to Full Moonlight Has a Long‐Term Impact on Brassica juncea Cell Activity and Growth

Plant, Cell &Environment, Volume 48, Issue 5, Page 3038-3051, May 2025.
ABSTRACT Lunar farming, often regarded as a myth, is regularly practiced in many places around the world (e.g., India) where framers organized their agricultural activities according to moon phases. Early and recent work showed that exposure to moonlight affects the life cycle of plants, from seed germination and vegetative growth to fruit maturation ...
Govindegowda Priyanka, Jeevan R. Singiri, Nurit Novoplansky, Gideon Grafi   +3 more
wiley   +1 more source

TOX and TOX2 transcription factors cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance A recent exciting development in cancer therapy involves using a patient’s own immune system to attack cancers. The attack is carried out by CD8+ T cells that destroy the malignant cells; after infiltrating tumors, however, these cells ...
Hyungseok Seo, Joyce Chen, Edahí González-Avalos, Daniela Samaniego-Castruita, Arundhoti Das, Yueqiang H. Wang, Isaac F. López-Moyado, Romain O. Georges, Wade Zhang, A. Onodera, Cheng-Jang Wu, Li-Fan Lu, P. Hogan, A. Bhandoola, A. Rao   +14 more
semanticscholar   +1 more source

Large-scale gene expression study in the ophiuroid Amphiura filiformis provides insights into evolution of gene regulatory networks [PDF]

, 2016
BACKGROUND: The evolutionary mechanisms involved in shaping complex gene regulatory networks (GRN) that encode for morphologically similar structures in distantly related animals remain elusive.
Czarkwiani, A, Dupont, S, Dylus, DV, Oliveri, P, Ortega-Martinez, O, Stångberg, J   +5 more
core   +3 more sources

The SlGRAS9‐SlMYC1 regulatory module controls glandular trichome formation and modulates resilience to pest in tomato

The Plant Journal, Volume 122, Issue 3, May 2025.
Significance Statement Trichomes contribute to plant adaptive responses to environmental stresses. Our knowledge of the factors that govern the formation of various trichome types and the means by which these structures provide tolerance to environmental stresses remains only partially understood. Our study unveiled the role of SlGRAS9‐SlMYC1 module of
Yuan Shi, Yan Wang, Yaowen Pan, Changhao Deng, Ting Zeng, Deding Su, Wang Lu, Yuxiang Lin, Junnan Han, Wei Deng, Shuang Wu, Yudong Liu, Ning Li, Ji Li, Biao Dong, Ghassen Abid, Mondher Bouzayen, Julien Pirrello, Zhengguo Li, Baowen Huang   +19 more
wiley   +1 more source