Results 91 to 100 of about 38,330 (231)

GCV phosphates are transferred between HeLa cells despite lack of bystander cytotoxicity [PDF]

Gene Therapy, 2005
The role of gap junctional intercellular communication (GJIC) in bystander killing with herpes simplex virus thymidine kinase (HSV-TK) and ganciclovir (GCV) was evaluated in U251 cells expressing a dominant-negative connexin 43 cDNA (DN14), and in HeLa cells, reportedly devoid of connexin protein. These cell lines both exhibited 0% GJIC when assayed by
B G, Gentry, M, Im, P D, Boucher, R J, Ruch, D S, Shewach   +4 more
openaire   +2 more sources

Modelling non‐linear psychological processes: Reviewing and evaluating non‐parametric approaches and their applicability to intensive longitudinal data

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Psychological concepts are increasingly understood as complex dynamic systems that change over time. To study these complex systems, researchers are increasingly gathering intensive longitudinal data (ILD), revealing non‐linear phenomena such as asymptotic growth, mean‐level switching, and regulatory oscillations.
Jan I. Failenschmid, Leonie V. D. E. Vogelsmeier, Joris Mulder, Joran Jongerling   +3 more
wiley   +1 more source

Semivariogram methods for modeling Whittle-Mat\'ern priors in Bayesian inverse problems

, 2020
We present a new technique, based on semivariogram methodology, for obtaining point estimates for use in prior modeling for solving Bayesian inverse problems.
Bardsley, Johnathan M., Brown, Richard D., Cui, Tiangang   +2 more
core   +1 more source

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Screening for Fall Armyworm (Spodoptera frugiperda J. E. Smith) Resistance in Early‐Maturing Tropical Maize Adapted to Sub‐Saharan Africa

Plant Breeding, EarlyView.
ABSTRACT Fall armyworm (FAW) (Spodoptera frugiperda J. E. Smith) has emerged as a serious pest since 2016 in Africa, affecting the food security and livelihoods of millions of smallholder farmers, especially those growing maize. Native genetic resistance to FAW is essential for reducing yield loss.
Adamu Masari Abubakar, Idris Ishola Adejumobi, Muhyideen Oyekunle, Tegawende Odette Bonkoungou, Usman Muhammad, Onehireba Udah, Baffour Badu‐Apraku   +6 more
wiley   +1 more source

Biotransformation of monoterpenols upon pre‐treatment with oregano essential oil vapour alleviates downy mildew susceptibility in grapevine leaves

Plant Biology, EarlyView.
Pre‐treatment of grapevine plants with oregano essential oil vapour alleviates downy mildew susceptibility by accumulation of monoterpenol glycosides. Abstract Grapevine downy mildew, caused by the oomycete Plasmopara viticola, is a destructive disease that causes major economic losses as most elite grapevine cultivars are susceptible to this pathogen.
J. R. P. E. Mars, R. M. de Graaf, R. S. Jansen, S. Coolen, P. H. J. Kouwer, J. L. Peters, R. A. Anaia   +6 more
wiley   +1 more source

Aging‐Derived Alterations in Genomic, Immune, and Metabolic Networks: Implications for Cancer Development and Therapy

MedComm – Oncology, Volume 5, Issue 1, March 2026.
Ageing acts as a double‐edged sword in cancer. In the elderly, open chromatin, immunosenescence, and chronic inflammation drive SASP (IL‐6, MMPs), MDSC accumulation and T‐cell suppression, fostering tumor‐promoting microenvironments and limited therapeutic benefit.
Qi Wang, Xue Sun, Xinhao Han, Xingda Zhang, Wenzheng Wang, Hongbin Wang, He Ren, Lina Gu   +7 more
wiley   +1 more source

The Centers of Early-Type Galaxies with HST III: Non-Parametric Recovery of Stellar Luminosity Distributions

, 1996
We have non-parametrically determined the luminosity density profiles and their logarithmic slopes for 42 early-type galaxies observed with HST. Assuming that the isodensity contours are spheroidal, then the luminosity density is uniquely determined from
Ajhar, Edward, Byun, Yong-Ik, Dressler, Alan, Faber, Sandra, Gebhardt, Karl, Grillmair, Carl, Kormendy, John, Lauer, Tod, Richstone, Douglas, Tremaine, Scott   +9 more
core   +1 more source

Market Insurance and Risk Pooling in U.S. Crop Insurance

Agricultural Economics, Volume 57, Issue 2, March 2026.
ABSTRACT A common assumption is that multiple‐peril crop insurance markets suffer from market failures, thus justifying government intervention in the form of premium subsidies, operating allowances, and reinsurance agreements. One prominent rationale for intervention involves geographic correlation in agricultural production which leads to systemic ...
Fan Fan, Yong Liu, A. Ford Ramsey, David J. Leatham   +3 more
wiley   +1 more source

HSV-TK/GCV 系统治疗口腔鳞癌移植瘤的研究

Zhongshan Daxue xuebao. Yixue kexue ban, 2002
【目的】探讨腺病毒介导单纯疱疹病毒胸苷激酶基因(AdCMVHSV-TK)/ 丙氧鸟苷(GCV)自杀基因系统对口腔 鳞癌移植瘤的治疗作用。【方法】Tca8113 细胞接种于裸鼠右侧腋下, 移植瘤形成时随机分成4 组:①空白对照组, ②Ad- CMVHSV-TK 对照组(2×109 PFU, 瘤内注射), ③GCV 对照组(25 mg/ kg , Bid ×6, 腹腔注射), ④AdCM VHSV-TK/ GCV 治疗 组, 并开始治疗。观察肿瘤的生长状态、计算抑瘤率和肿瘤群体倍增时间 ...
黄洪章, 王安训, 李　苏
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