Results 11 to 20 of about 38,330 (231)

Renal maturation and catch-up clearance of ganciclovir in a preterm neonate: Bayesian pharmacokinetic analysis using a population model. [PDF]

J Pharm Health Care Sci
Background Congenital cytomegalovirus (CMV) infection is a major cause of neonatal morbidity. However, optimizing ganciclovir (GCV) dosing in preterm infants is complicated by immature renal function and developmental pharmacokinetics.
Kata K, Inomata S, Nishikawa M, Ide H, Nakamura K, Yoshida T, Taguchi M.   +6 more
europepmc   +2 more sources

Morphometric Analysis of Great Cardiac Vein and its Clinical Implication-A Cadaveric Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Great Cardiac Vein (GCV) is the longest venous vessel of heart. It is the main tributary of the coronary sinus and anterior wall of the left ventricle and interventricular septum are drained by GCV. Aim: To study the morphometry of GCV and
Jolly Agarwal, Anurag Agrawal, Virendra Kumar, DN Sinha   +3 more
doaj   +1 more source

Low-dose ganciclovir ameliorates dextran sulfate sodium-induced ulcerative colitis through inhibiting macrophage STING activation in mice

Frontiers in Pharmacology, 2022
Ganciclovir (GCV) is a prodrug nucleoside analogue and is clinically used as antiviral drug for the treatment of cytomegalovirus (CMV) and other infections.
Lin-Kong Gong, Xiaodong Yang, Juan Yang, Shu Wu, Yue Chen, Jiang-Tao Zhang, Zhi-Hong Wang, Li-Hua Chen, Chungen Xing, Tong Liu, Tong Liu, Tong Liu   +11 more
doaj   +1 more source

Ganciclovir-induced mutations are present in a diverse spectrum of post-transplant malignancies

Genome Medicine, 2022
Background Ganciclovir (GCV) is widely used in solid organ and haematopoietic stem cell transplant patients for prophylaxis and treatment of cytomegalovirus. It has long been considered a mutagen and carcinogen. However, the contribution of GCV to cancer
Hu Fang, Helen H. N. Yan, Rebecca A. Bilardi, Christoffer Flensburg, Haocheng Yang, Jayne A. Barbour, Hoi Cheong Siu, Michelle Turski, Edward Chew, Zhen Xu, Siu T. Lam, Rakesh Sharma, Mengya Xu, Junshi Li, Ho W. Ip, Carol Y. M. Cheung, Michael S. Y. Huen, E. Alejandro Sweet-Cordero, Ian J. Majewski, Suet Y. Leung, Jason W. H. Wong   +20 more
doaj   +1 more source

PEMODELAN ANGKA HARAPAN HIDUP DAN ANGKA KEMATIAN BAYI DI KALIMANTAN DENGAN REGRESI NONPARAMETRIK SPLINE BIRESPON

Barekeng, 2021
Penelitian ini menggunakan model regresi nonparametrik birespon dengan pendekatan spline truncated. Model tersebut digunakan untuk menyelesaikan permasalahan analisis regresi yang bentuk kurvanya tidak diketahui.
Aprianti Boma Padatuan, Sifriyani Sifriyani, Surya Prangga   +2 more
doaj   +1 more source

TUBERCULOSIS CASE MODEL USING GCV AND UBR KNOT SELECTION METHODS IN TRUNCATED SPLINE NONPARAMETRIC REGRESSION

Barekeng, 2023
The nonparametric regression approach is used when the shape of the regression curve is not known. The advantage of nonparametric regression is that it has a high degree of flexibility.
Sitti Anggraeni, Sifriyani Sifriyani, Qonita Qurrota A'yun   +2 more
doaj   +1 more source

REGRESSION NONPARAMETRIC SPLINE ESTIMATION ON BLOOD GLUCOSE OF INPATIENTS DIABETES MELLITUS AT SAMARINDA HOSPITAL

Barekeng, 2023
This study used a biresponse nonparametric regression method with truncated spline estimation that used two response variables. Nonparametric regression method is used when the regression curve is not known for its shape and pattern.One of the ...
Ar Ruum Mia Sari, Sifriyani Sifriyani, Mohammad Nurul Huda   +2 more
doaj   +1 more source

Genetic studies on diversity and variability in dolichos bean (Lablab purpureus L.)

Electronic Journal of Plant Breeding, 2021
The field experiment was carried out by using twenty-six field bean genotypes to study the genetic divergence and genetic variability parameters. The characters studied were days to 50 per cent flowering, days to maturity, plant height, the number of
K. Geetha* and S. Divya
doaj   +1 more source

Neural differentiation of glioblastoma cell lines via a herpes simplex virus thymidine kinase/ganciclovir system driven by a glial fibrillary acidic protein promoter

PLoS ONE, 2021
Glioblastoma is a malignant brain tumor with poor prognosis that rapidly acquires resistance to available clinical treatments. The herpes simplex virus thymidine kinase/ganciclovir (HSVtk/GCV) system produces the selective elimination of HSVtk-positive ...
Elizabeth Wei-Chia Luo, Meng-Lin Liao, Chung-Liang Chien   +2 more
doaj   +2 more sources

Gene conversion-like events in the diversification of human rearranged IGHV3-23*01 gene sequences

Frontiers in Immunology, 2012
Gene conversion (GCV) as a mechanism of immunoglobulin diversification is well established in a few species. However, definitive evidence of GCV-like events in human immunoglobulin genes is scarce. GCV is mediated by activation-induced cytidine deaminase
Bhargavi eDuvvuri, Gillian E Wu
doaj   +1 more source