Results 151 to 160 of about 30,228 (205)

The Scent of a Therapy for Spinal Cord Injury: Growth Factors and Their Potential to Modulate Olfactory Ensheathing Cells. [PDF]

Biomolecules
Seeberger TSG, Murtaza M, Rayfield AJ, St John JA, Reshamwala R.   +4 more
europepmc   +1 more source

Cannabidiol-rich extract suppresses the activation of proinflammatory genes IL-1β and IL-6 in equine mesenchymal stem cells stimulated with lipopolysaccharide. [PDF]

Vet Res Commun
da Costa Kamura B, de Oliveira Ferreira LV, Chimenes ND, de Oliveira JPM, Rodriguez-Sanchez DN, de Carvalho M, Amorim RM.   +6 more
europepmc   +1 more source

Cell-based regenerative interventions in Parkinson's disease: Overcoming pharmacological limitations. [PDF]

Acta Pharm Sin B
Padilla AL, Lanciego JL, Vila M, de Castro F, Pozo D, Rodríguez de Fonseca F, Serrano A, Sáez-Valero J, Núñez L, Villalobos C, Tapias V.   +10 more
europepmc   +1 more source

Aqueous Humor Cytokine Profiles in Congenital Cataracts With Posterior Polar Abnormality and Associations With Postoperative Complications. [PDF]

Invest Ophthalmol Vis Sci
Zhang Q, Qiu X, Chung KY, Zhang J, Lin Z, Lin X, Lin Y, Chen W, Chen H.   +8 more
europepmc   +1 more source

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GDNF and Addiction

Reviews in the Neurosciences, 2005
Biochemical adaptations to drugs of abuse and alcohol are especially profound in midbrain dopaminergic neurons. Long-lasting molecular and structural changes in mesolimbic dopaminergic neurons that result from chronic exposure to drugs of abuse and alcohol are thought to underlie adverse behaviors such as compulsive drug seeking and relapse.
Dorit, Ron, Patricia H, Janak
openaire   +2 more sources

GDNF isoform affects intracellular trafficking and secretion of GDNF in neuronal cells

Brain Research, 2008
Glial cell line derived neurotrophic factor (GDNF) plays a critical role in central and peripheral neuron survival and function. In human and rodents, GDNF exists in an alternative spliced isoform (GDNF Delta 78), which has a 78 bp deletion in the pro-region of the GDNF encoding sequence. Whether the GDNF isoform affects GDNF function is unknown. Here,
Shu-Hong Huang, Zhe-Yu Chen, Zhao Geng   +2 more
exaly   +3 more sources

Neuroprotective and neurorestorative properties of GDNF

Annals of Neurology, 1998
AbstractGlial cell line‐derived neurotrophic factor (GDNF) promotes recovery of the injured nigrostriatal dopamine system and improves motor functions in both rodent and nonhuman primate models of Parkinson's disease (PD). The neurorestorative effects of a single administration of GDNF last for at least 1 month and can be maintained in rhesus monkeys ...
D M, Gash, Z, Zhang, G, Gerhardt
openaire   +2 more sources

GDNF therapy for Parkinson’s disease

Expert Review of Neurotherapeutics, 2008
With an increase in the aging population, the incidence of Parkinson's disease (PD), a disabling neurodegenerative disorder mainly affecting motor function, will inevitably present a challenge to an already overburdened healthcare system. Current medical and surgical therapies offer symptomatic relief but do not provide a cure.
Murray, Hong, Karim, Mukhida, Ivar, Mendez   +2 more
openaire   +2 more sources

GDNF deficit in Hirschsprung's disease

Journal of Pediatric Surgery, 1998
In 1996, the glial cell line-derived neurotrophic factor (GDNF) was identified as one of the ligands of the RET transmembrane receptor. In the same year, GDNF mutations were found in association with RET protooncogene mutations in Hirschsprung patients.
MARTUCCIELLO, GIUSEPPE, H. Thompson, C. Mazzola, A. Morando, M. Bertagnon, F. Negri, A. Brizzolara, L. Rocchetti, C. Gambini, JASONNI, VINCENZO   +9 more
openaire   +3 more sources