Results 161 to 170 of about 30,228 (205)

GDNF EXPRESSION IN WILMS TUMOR

Journal of Urology, 2001
Wilms tumor or nephroblastoma is a developmental tumor of the kidney and one of the most frequent solid tumors in childhood. It derives from metanephrotic blastema and mimics nephrogenesis in a disorganized manner, offering an adequate model for study of human nephrogenesis. GDNF (glial cell line derived neurotrophic factor), a potent proliferation and
E, Séguier-Lipszyc, A, El-Ghoneimi, C, Brinon, A, Florentin, M, Simonneau, Y, Aigrain, M, Peuchmaur   +6 more
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Characterization of a multicomponent receptor for GDNF

Nature, 1996
Glial-cell-line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons, and is essential for the development of kidneys and the enteric nervous system. Despite the potential clinical and physiological importance of GDNF, its mechanism of action is unknown.
Treanor, James, Goodman, Laurie, de Sauvage, Frederic, Stone, Donna, Poulsen, Kris, Beck, Claus, Gray, Christa, Armanini, Mark, Pollock, Richard, Hefti, Franz, Phillips, Heidi, Goddard, Audry, Moore, Mark, Buj-Bello, Anna, Davies, Alun, Asai, Naoya, Takahashi, Masahide, Vandlen, Richard, Henderson, Christopher, Rosenthal, Arnon   +19 more
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GDNF - a stranger in the TGF-β superfamily? [PDF]

FEBS Journal, 2000
Glial cell line‐derived neurotrophic factor (GDNF) family, consisting of GDNF, neurturin, artemin and persephin are distant members of the transforming growth factor‐β (TGF‐β) superfamily. Unlike other members of the TGF‐β superfamily, which signal through the receptor serine‐threonine kinases, GDNF family ligands activate intracellular signalling ...
M Saarma
exaly   +3 more sources

Neuroprotection by GDNF in the ischemic brain

Growth Factors, 2012
The glial cell line-derived neurotrophic factor (GDNF) was first identified as a survival factor for midbrain dopaminergic neurons, but additional studies provided evidences for a role as a trophic factor for other neurons of the central and peripheral nervous systems.
Emília P, Duarte, Michele, Curcio, Lorella M, Canzoniero, Carlos B, Duarte   +3 more
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Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse

Experimental Neurology, 1999
The GDNF family of neurotrophic factors currently has four members: neurturin (NRTN), glial cell line-derived neurotrophic factor (GDNF), persephin, and artemin. These proteins are potent survival factors for several populations of central and peripheral neurons.
J P, Golden, J A, DeMaro, P A, Osborne, J, Milbrandt, E M, Johnson   +4 more
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GDNF delivery for Parkinson’s disease

2007
The mainstays of Parkinson's disease (PD) treatment remain symptomatic, including initial dopamine replacement and subsequent deep brain stimulation, however, neither of these approaches is neuroprotective. Neurotrophic factors - proteins that activate cell signalling pathways regulating neuronal survival, differentiation, growth and regeneration ...
N K, Patel, S S, Gill
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GDNF and somatostatin in sensory neurones

Current Opinion in Pharmacology, 2003
Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, the SOM stable analogue octreotide (OCT) is used to treat opioid-resistant pain. In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory neurones exerts anti-inflammatory ...
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GDNF AND CISPLATIN NEURONOPATHY

Journal of the Peripheral Nervous System, 2000
GDNF is a growth factor produced in the central nervous system by glial cells and has a trophic action on dopaminergic neurons. However, GDNF mRNA is expressed also in the dorsal root ganglia (DRG), suggesting that it may act as a neurotrophic factor on different neuronal populations. The three different GDNF receptor components are highly expressed in
G. Cavaletti, E. Dondè, P. Marmiroli, G. Tredici   +3 more
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GDNF

Molecular Neurobiology, 1999
The identification of novel factors that promote neuronal survival could have profound effects on developing new therapeutics for neurodegenerative disorders. Glial cell line-derived neurotrophic factor (GDNF) is a novel protein purified and cloned based on its marked ability to promote dopaminergic neuronal function.
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Novel structure of the human GDNF gene

Brain Research, 1998
Glial cell line-derived neurotrophic factor (GDNF) is the most potent known survival factor for substantia nigra neurons, which degenerate in Parkinson's disease, for spinal motoneurons, which die in Lou Gehrig's disease (ALS), and for Purkinje neurons, the critical outflow cells of the cerebellum.
D, Woodbury, D G, Schaar, L, Ramakrishnan, I B, Black   +3 more
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