Results 191 to 200 of about 37,648 (242)

GDNF therapy for Parkinson’s disease

Expert Review of Neurotherapeutics, 2008
With an increase in the aging population, the incidence of Parkinson's disease (PD), a disabling neurodegenerative disorder mainly affecting motor function, will inevitably present a challenge to an already overburdened healthcare system. Current medical and surgical therapies offer symptomatic relief but do not provide a cure.
Murray, Hong, Karim, Mukhida, Ivar, Mendez   +2 more
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GDNF EXPRESSION IN WILMS TUMOR

Journal of Urology, 2001
Wilms tumor or nephroblastoma is a developmental tumor of the kidney and one of the most frequent solid tumors in childhood. It derives from metanephrotic blastema and mimics nephrogenesis in a disorganized manner, offering an adequate model for study of human nephrogenesis. GDNF (glial cell line derived neurotrophic factor), a potent proliferation and
E, Séguier-Lipszyc, A, El-Ghoneimi, C, Brinon, A, Florentin, M, Simonneau, Y, Aigrain, M, Peuchmaur   +6 more
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GDNF deficit in Hirschsprung's disease

Journal of Pediatric Surgery, 1998
In 1996, the glial cell line-derived neurotrophic factor (GDNF) was identified as one of the ligands of the RET transmembrane receptor. In the same year, GDNF mutations were found in association with RET protooncogene mutations in Hirschsprung patients.
MARTUCCIELLO, GIUSEPPE, H. Thompson, C. Mazzola, A. Morando, M. Bertagnon, F. Negri, A. Brizzolara, L. Rocchetti, C. Gambini, JASONNI, VINCENZO   +9 more
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Neuroprotection by GDNF in the ischemic brain

Growth Factors, 2012
The glial cell line-derived neurotrophic factor (GDNF) was first identified as a survival factor for midbrain dopaminergic neurons, but additional studies provided evidences for a role as a trophic factor for other neurons of the central and peripheral nervous systems.
Emília P, Duarte, Michele, Curcio, Lorella M, Canzoniero, Carlos B, Duarte   +3 more
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GDNF delivery for Parkinson’s disease

2007
The mainstays of Parkinson's disease (PD) treatment remain symptomatic, including initial dopamine replacement and subsequent deep brain stimulation, however, neither of these approaches is neuroprotective. Neurotrophic factors - proteins that activate cell signalling pathways regulating neuronal survival, differentiation, growth and regeneration ...
N K, Patel, S S, Gill
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Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse

Experimental Neurology, 1999
The GDNF family of neurotrophic factors currently has four members: neurturin (NRTN), glial cell line-derived neurotrophic factor (GDNF), persephin, and artemin. These proteins are potent survival factors for several populations of central and peripheral neurons.
J P, Golden, J A, DeMaro, P A, Osborne, J, Milbrandt, E M, Johnson   +4 more
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GDNF and somatostatin in sensory neurones

Current Opinion in Pharmacology, 2003
Somatostatin (SOM) is a regulatory peptide produced throughout the central nervous system and in most major peripheral organs. In humans, the SOM stable analogue octreotide (OCT) is used to treat opioid-resistant pain. In animal models, SOM and OCT are analgesics and SOM released from the peripheral endings of sensory neurones exerts anti-inflammatory ...
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GDNF AND CISPLATIN NEURONOPATHY

Journal of the Peripheral Nervous System, 2000
GDNF is a growth factor produced in the central nervous system by glial cells and has a trophic action on dopaminergic neurons. However, GDNF mRNA is expressed also in the dorsal root ganglia (DRG), suggesting that it may act as a neurotrophic factor on different neuronal populations. The three different GDNF receptor components are highly expressed in
G. Cavaletti, E. Dondè, P. Marmiroli, G. Tredici   +3 more
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GDNF

Molecular Neurobiology, 1999
The identification of novel factors that promote neuronal survival could have profound effects on developing new therapeutics for neurodegenerative disorders. Glial cell line-derived neurotrophic factor (GDNF) is a novel protein purified and cloned based on its marked ability to promote dopaminergic neuronal function.
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GDNF Prevents Addiction

Science Signaling, 2000
Drugs of abuse, such as cocaine and morphine, induce a type of synaptic plasticity in the mesolimbic dopamine system. Messer et al. determined that glial-derived neurotrophic factor (GDNF) was involved in the biochemical and behavioral changes associated with chronic drug exposure. Their data show that infusion of
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