Results 81 to 90 of about 16,607 (189)
The assessment and verification of high-resolution ensemble forecast for a heavy rainstorm
暴雨灾害, 2020 Based on a high-resolution (3 km) model with convection-allowing microphysics scheme,a storm-scale ensemble forecast (SSEF) was carried out for a heavy rainstorm which occurred in the western mountainous area of Hubei Province on 22 April 2018.
Jun LI, Jun DU, Jianyu XU, Minghuan WANG
doaj +1 more source
Epilepsy syndromes classification
Epilepsia Open, EarlyView.Abstract Epilepsy syndromes are distinct electroclinical entities which have been recently defined by the International League Against Epilepsy Nosology and Definitions Task Force. Each syndrome is associated with “a characteristic cluster of clinical and EEG features, often supported by specific etiologic findings”.
Elaine C. Wirrell +4 more
wiley +1 more source
Regulating Rac in the Nervous System: Molecular Function and Disease Implication of Rac GEFs and GAPs [PDF]
, 2015 Rho family GTPases, including RhoA, Rac1, and Cdc42 as the most studied members, are master regulators of actin cytoskeletal organization. Rho GTPases control various aspects of the nervous systemand are associated with a number of neuropsychiatric and ...
Bai, Yanyang +3 more
core +1 more source
Genetic screening of Scandinavian families with febrile seizures and epilepsy or GEFS+
, 2008 Background - Mutations in the three genes SCN1A, SCN1B and GABRG2, all encoding subunits of ion channels, have been known to cause generalized epilepsy with febrile seizures plus (GEFS+) in families of different origin.
Brandal, K +8 more
core +1 more source
Affinity Precipitation of Active Rho-GEFs Using a GST-tagged Mutant Rho Protein (GST-RhoA(G17A)) from Epithelial Cell Lysates [PDF]
, 2012 Proteins of the Rho family of small GTPases are central regulators of the cytoskeleton, and control a large variety of cellular processes, including cell migration, gene expression, cell cycle progression and cell adhesion 1.
Garcia-Mata, Rafael +4 more
core +1 more source
Epilepsia Open, EarlyView.Abstract Objective To determine whether computational protein‐stability predictions discriminate pathogenic from benign SCN1A missense variants, and to characterize the structural distribution of predicted destabilization among pathogenic variants. Methods On an AlphaFold3‐predicted Nav1.1 structure, FoldX, and Rosetta Cartesian ΔΔG were computed for a
Youngkyu Shim +3 more
wiley +1 more source
Coupling receptor tyrosine kinases to Rho GTPases--GEFs what\u27s the link
, 2006 Rho GTPases are molecular switches involved in the regulation of many cellular processes. This review summarizes work examining how stimulation of receptor tyrosine kinases (RTKs) leads to the activation of Rho guanine nucleotide exchange factors (GEFs ...
Schiller, Martin R.
core +1 more source
Epilepsia Open, EarlyView.Abstract Objective Dravet syndrome (DS) is a rare early‐onset developmental and epileptic encephalopathy with persistent delays between seizure onset and diagnosis. The DS'coverED study aimed to characterize current diagnostic timelines by examining each step and its duration, identifying residual barriers, and actionable solutions to optimize the ...
Loucas Christodoulou +9 more
wiley +1 more source