Results 101 to 110 of about 16,607 (189)

GABRG2 mutations in genetic epilepsy with febrile seizures plus: structure, roles, and molecular genetics

open access: yesJournal of Translational Medicine
Genetic epilepsy with febrile seizures plus (GEFS+) is a genetic epilepsy syndrome characterized by a marked hereditary tendency inherited as an autosomal dominant trait.
Xinxiao Li   +8 more
doaj   +1 more source

Indications for genetic testing in adults with focal segmental glomerulosclerosis

open access: yesNefrología (English Edition)
Focal segmental glomerulosclerosis (FSGS) is a histological pattern of injury that derives from various pathological processes that affect podocytes, resulting in loss of selectivity of the glomerular filtration membrane, proteinuria and the development ...
Melissa Pilco-Terán   +7 more
doaj   +1 more source

The Emerging Role of Guanine Exchange Factors in ALS and other neurodegenerative diseases

open access: yesFrontiers in Cellular Neuroscience, 2014
Small GTPases participate in a broad range of cellular processes such as proliferation, differentiation and migration. The exchange of GDP for GTP resulting in the activation of these GTPases is catalyzed by a group of enzymes called guanine nucleotide ...
Cristian eDroppelmann   +5 more
doaj   +1 more source

How Program‐ and Community‐Led Design Settings Affect Resilience Approaches to Sustainable Development Projects

open access: yesSustainable Development, EarlyView.
ABSTRACT Sustainable Development interventions must deal with rapid and novel changes affecting complex social‐ecological systems, calling for design based on a resilience approach. However, limited analytical attention has been paid to the design settings in which such approaches are deployed.
Yiheyis Maru   +6 more
wiley   +1 more source

A lysosome‐targeted ultra‐sensitive viscosity probe for monitoring viscosity alterations during chemotherapy

open access: yesSmart Molecules, EarlyView.
A novel chemosensing platform based on a molecular rotor architecture is established for specific, dynamic detection of lysosomal viscosity. The platform allows real‐time tracking of lysosomal viscosity fluctuations induced by various chemotherapeutic agents, highlighting its significant potential as a powerful tool for early cancer diagnostics and ...
Haoyang Song   +6 more
wiley   +1 more source

Cascade Deep Learning With Physics Guidance for Typhoon Intensity Prediction

open access: yesCAAI Transactions on Intelligence Technology, EarlyView.
ABSTRACT Typhoons pose a significant threat to both human safety and economic stability. As a crucial metric for assessing their destructive potential, typhoon intensity (TI) prediction has become an important research focus, with numerous methods developed.
Zhengya Sun   +4 more
wiley   +1 more source

The Function of Fission Yeast Rho1-GEFs in the Control of Cell Growth and Division

open access: yes, 2018
[EN]Guanine nucleotide exchange factors (GEFs) are directly responsible for the activation of Rho-family GTPases in response to physical and chemical stimuli and ultimately regulate numerous cellular responses such as polarized growth, morphogenesis, and
Edreira, Tomás   +5 more
core   +1 more source

Size, Spines, and Nests: What Drives Variation in Death‐Feigning Behavior in Fungus‐Farming Ants?

open access: yesIntegrative Zoology, EarlyView.
We investigated death‐feigning (DF; thanatosis) in fungus‐farming ants, testing how stimulus intensity, morphology, and nest traits shape its occurrence and duration using generalized linear mixed models. Stronger stimuli increased both likelihood and duration, but most variation was structured across species, colonies, and individuals.
Danon Clemes Cardoso   +2 more
wiley   +1 more source

Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex

open access: yes, 2017
International audienceMacrophages play crucial role in tissue homeostasis and the innate and adaptive immune response. Depending on the state of activation macrophages acquire distinct phenotypes that depend on actin, which is regulated by small GTPase ...
Chen, Wei   +11 more
core   +1 more source

Changes in Site Occupancy of Marsh‐Breeding Frogs Are Associated With Surrounding Land Cover: Implications for Conservation Planning

open access: yesAnimal Conservation, EarlyView.
To help ensure the growth and persistence of frog populations, we quantified changes in frog occurrence as a function of concurrent changes in land cover in the surrounding landscape of eight marsh‐breeding frog species, or groups of species. We used data from the Great Lakes Marsh Monitoring Program delivered by Birds Canada at 377 sites across four ...
Douglas C. Tozer   +4 more
wiley   +1 more source

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