Results 121 to 130 of about 16,607 (189)

CD93—An emerging vascular target in cancer therapy

British Journal of Pharmacology, EarlyView.
Abstract CD93 is a single‐pass transmembrane glycoprotein that belongs to the C‐type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis.
Beatriz de Alves Pereira, Stefano Barbera, Roberta Lugano, Anna Dimberg   +3 more
wiley   +1 more source

Protected areas on international borders show uneven conservation outcomes

Conservation Biology, EarlyView.
Abstract Border protected areas (BPAs) are national protected areas that are immediately adjacent to a country's border or span two or more countries; they are characterized by distinctive opportunities and pressures. They play a critical role in protecting carbon‐rich ecosystems, conserving endangered biodiversity, reducing cross‐border environmental ...
Rachakonda Sreekar, Hoong Chen Teo, Tiantian Zhang, Jiajia Liu, Aakash Lamba, Jun Ying Lim, Lian Pin Koh, Sean Jing Wen Ng, Janice Ser Huay Lee, James E. M. Watson, Yiwen Zeng   +10 more
wiley   +1 more source

Lack of Capacity: The Not‐So‐Hidden Factor Undermining Fisheries Governance

Fish and Fisheries, EarlyView.
ABSTRACT The demand for marine resources is increasing, and an increasing number of fish stocks are fully or overexploited. To turn this downward projection around, states need to strengthen the effectiveness, equity and implementation of fisheries management measures.
Haas Bianca, Aqorau Transform, Lennan Mitchell   +2 more
wiley   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

SOS1, ARHGEF1, and DOCK2 rho-GEFs mediate JAK-Dependent LFA-1 activation by chemokines

, 2016
JAK-dependent activation of the rho module of integrin affinity triggering mediates chemokine-induced leukocyte adhesion. However, the signaling events linking JAKs to rho small GTPase activation by chemokines is still incompletely described.
G. Scita, TOFFALI, Lara, Mirenda, Michela, L. Toffali, A. Montresor, M. Mirenda, LAUDANNA, Carlo, MONTRESOR, Alessio, Scita, Giorgio, C. Laudanna   +9 more
core   +1 more source

Harnessing benzamides as plant stress inhibitors, growth promoters and in management of crop resilience—A review

Plant Biology, EarlyView.
Benzamides boost crop resilience by inhibiting poly(ADP‐ribose) polymerase (PARP) to enhance stress tolerance and, through their antimicrobial, herbicidal, and insecticidal derivatives, they offer broad protection for sustainable crop improvement. Abstract Benzamides have emerged as potent stress inhibitors and growth promoters in plant biotechnology ...
M. J. Koetle, T. E. Motaung, S. O. Amoo
wiley   +1 more source

Effect of constant and acute light during the scotophase on GEFS+ and control sleep.

, 2015
(A) Sleep profiles of control (n = 83) and GEFS+ (n = 95) flies under constant light/light (LL) exposure. (B) Total sleep and (C) sleep latency during subjective night under LD and LL conditions; Rank Sum Tests.
Patrick Lansdon (794165), Emily Petruccelli (794164), Toshihiro Kitamoto (469256)   +2 more
core   +1 more source

Trait‐based restoration in African dryland restoration projects: overcoming systemic and scientific barriers for a viable future

Restoration Ecology, EarlyView.
Abstract Introduction African dryland restoration continues to show low success rates despite major pledges, due to persistent water scarcity, ecological complexity, and limited use of trait‐based restoration (TBR). Functional trait‐based approaches, which match species selection to adaptive traits, could strengthen ecosystem recovery under arid ...
Paulina N. Naupu, Theo D. Wassenaar, Rolf W. Becker, Ezekeil Kwembeya   +3 more
wiley   +1 more source

GEFs and Rac GTPases control directional specificity of neurite extension along the anterior-posterior axis

, 2016
© 2016, National Academy of Sciences. All rights reserved. Although previous studies have identified many extracellular guidance molecules and intracellular signaling proteins that regulate axonal outgrowth and extension, most were conducted in the ...
Zheng, Chaogu, Diaz-Cuadros, Margarete, Chalfie, Martin   +2 more
core   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source