Results 111 to 120 of about 16,607 (189)

Utility of Global Ensemble Forecast System (GEFS) Reforecast for Medium-Range Drought Prediction in India

, 2016
Medium-range (~7 days) forecasts of agricultural and hydrologic droughts can help in decision-making in agriculture and water resources management. India has witnessed severe losses due to extreme weather events during recent years and medium-range ...
Shah, Reepal D., Mishra, Vimal
core   +1 more source

SCN1A mutations in focal epilepsy with auditory features: widening the spectrum of GEFS plus

, 2019
Epilepsy with auditory features (EAF) is a focal epilepsy syndrome characterized by prominent auditory ictal manifestations. Two main genes, LGI1 and RELN, have been implicated in EAF, but the genetic aetiology remains unknown in half of families and ...
Tinuper, Paolo, Minardi, Raffaella, Menghi, Veronica, Pippucci, Tommaso, Mefford, Heather C, Marconi, Caterina, Muccioli, Lorenzo, Guerrini, Renzo, Marini, Carla, Baldassari, Sara, Caporali, Leonardo, Bisulli, Francesca, Cantalupo, Gaetano, Licchetta, Laura, Myers, Candace   +14 more
core   +2 more sources

Testing the Assumption That Tiger Population Recovery Increases Conflict Across Their Range

Animal Conservation, EarlyView.
Tiger population recovery is widely assumed to increase conflict with people, yet this assumption has rarely been examined using range‐wide evidence. Analysing data from ten tiger range countries between 2010 and 2025, we found no consistent evidence that tiger population recovery is associated with increased conflict incidents.
Rajendra Dhungana, Achyut Aryal, Daniel Ramp   +2 more
wiley   +1 more source

Rdl GABA_A knockdown in PDF-positive neurons differentially influences sleep latency in GEFS+ mutants.

, 2015
(A, B)Rdl knockdown in PDF neurons of control and heterozygous GEFS+ mutants; +/Rdl-RNAi (n = 55), pdf-GAL4/Rdl-RNAi (n = 49), GEFS+/+; +/Rdl-RNAi (n = 56), GEFS+/+; pdf-GAL4/Rdl-RNAi (n = 38).
Patrick Lansdon (794165), Emily Petruccelli (794164), Toshihiro Kitamoto (469256)   +2 more
core   +1 more source

Estimating of heavy metal concentration in agricultural soils from hyperspectral satellite sensor imagery: Considering the sources and migration pathways of pollutants

Ecological Indicators
The evolution of hyperspectral remote sensing and artificial intelligence technologies has led to a surge in their application for predicting Soil Heavy Metal Concentrations (SHMC).
Liwei Yao, Mingjie Xu, Yihui Liu, Ruiqing Niu, Xueling Wu, Yingxu Song   +5 more
doaj   +1 more source

Targeting KRAS for cancer therapy

British Journal of Pharmacology, EarlyView.
In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia, Ruonan Liu, Tonia A. Adamide, Isis E. Fernandez, Georgios T. Stathopoulos   +4 more
wiley   +1 more source

Identification of potentially pathogenic variants in patients with Genetic Epilepsy with Febrile Seizures Plus (GEFS+)

, 2020
Orientador: Íscia Teresinha Lopes-CendesDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: Introdução. A epilepsia genética com crises febris plus - GEFS+ (do inglês: genetic epilepsy with febrile seizures ...
Almendares Bonilla, Eimy Yoanneth, 1988-
core  

Enfermedad renal crónica por glomeruloesclerosis focal y segmentaria asociada a VIH en adolescente

Anales de la Facultad de Medicina
Las enfermedades glomerulares más frecuentes asociadas al síndrome nefrótico (SN) en adultos son la glomerulonefritis membranosa (GM) y la glomeruloesclerosis focal y segmentaria (GEFS), relacionada a VIH e infrecuente en adolescentes.
Luis Arellan-Bravo, Angie Romina Contreras Tovar, Valeria Evita Zevallos Guerra, Gianella D. Vera-Gonzales, Jorge Luis Hurtado-Alegre   +4 more
doaj   +1 more source

Thermodynamic characterisation of covalent ligand binding

British Journal of Pharmacology, EarlyView.
Background and Purpose Differential scanning fluorimetry (DSF) is a common and straightforward method to evaluate the thermal stability of proteins and has been heavily used for ligand binding characterisation as well as for screening. One class of compounds that is less typically evaluated by DSF are covalent binders.
Rebecca Hertzman, Maayan Lavie, Almog Nadir, Ronen Gabizon, Nir London   +4 more
wiley   +1 more source

Increased excitability of layer 5 neocortical pyramidal neurons and its contribution to seizure activity in Gabrg2 gene-deficient mice

iScience
Summary: Gabrg2fl/wtCre+ (CKO) mice are one of the models for studying “genetic epilepsy with febrile seizures plus (GEFS+).” A previous study revealed increased cortical excitability in CKO mice subjected to hyperthermia (CKO-heat mice), but the ...
Yangyang Sun, Zhuoqi Li, Baocong Yu, Chun Zhang, Lei Wang, Baorui Guo, Jiangwei Ding, Lifei Xiao, Peng Gao, Xinxiao Li, Tao Sun   +10 more
doaj   +1 more source