Results 101 to 110 of about 160,832 (337)

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Prolonged Prophylactic Antibiotics Based on Preoperative Bile Culture Reduce Surgical Site Infections After Pancreaticoduodenectomy Following Preoperative Biliary Drainage: A Propensity‐Matched Analysis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Objective The optimum duration of prophylactic antibiotics after pancreaticoduodenectomy following preoperative biliary drainage to prevent surgical site infections remains controversial. We evaluate whether a prolonged course of prophylactic antibiotics reduces surgical site infection after pancreaticoduodenectomy following biliary drainage ...
Kyohei Matsumoto, Atsushi Shimizu, Yuji Kitahata, Akihiro Takeuchi, Hideki Motobayashi, Masatoshi Sato, Tomohiro Yoshimura, Shinya Hayami, Atsushi Miyamoto, Manabu Kawai   +9 more
wiley   +1 more source

Understanding cisplatin resistance using cellular models [PDF]

, 2007
Many mechanisms of cisplatin resistance have been proposed from studies of cellular models of resistance including changes in cellular drug accumulation, detoxification of the drug, inhibition of apoptosis and repair of the DNA adducts.
Davey, Mary W., Stordal, Britta
core   +2 more sources

Impact of Sarcopenia During Induction Treatment in Patients With Unresectable Locally Advanced Pancreatic Cancer

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Chemotherapeutic advances have increased opportunities for conversion surgery (CS) in unresectable locally advanced (UR‐LA) pancreatic cancer (PC). However, the optimal indications for CS remain unclear. Sarcopenia has been associated with poor outcomes in PC, except UR‐LA PC. Herein, we aimed to evaluate the impact of sarcopenia on
Sho Uemura, Masayuki Tanaka, Minoru Kitago, Hiroshi Yagi, Yuta Abe, Yasushi Hasegawa, Shutaro Hori, Yutaka Nakano, Yuko Kitagawa   +8 more
wiley   +1 more source

Phase I study of nab-paclitaxel, gemcitabine, and bevacizumab in patients with advanced cancers. [PDF]

, 2018
BackgroundWe performed a phase I modified 3 + 3 dose escalation study to evaluate the safety and activity of bevacizumab plus gemcitabine and nab-paclitaxel in patients with advanced solid tumours.MethodsPatients were given fixed dose gemcitabine plus ...
Agarwal, Rishi, Bass, Allison, Bean, Stacie, Byers, Lauren, Falchook, Gerald, Fu, Siqing, Hess, Kenneth, Hong, David, Janku, Filip, Karp, Daniel, Kato, Shumei, Kurzrock, Razelle, Lim, JoAnn, Meric-Bernstam, Funda, Naing, Aung, Nguyen, Ly, Pant, Shubham, Piha-Paul, Sarina, Sen, Shiraj, Subbiah, Vivek, Tang, Chad, Tsimberidou, Apostolia, Westin, Shannon, Wu, Xifeng, Ye, Yuanqing   +24 more
core   +2 more sources

Potential Survival Benefit of Adjuvant Chemotherapy in Stage IV Intrahepatic Cholangiocarcinoma: A Multicenter, Stage‐Stratified Analysis

Annals of Gastroenterological Surgery, EarlyView.
This multicenter study suggests that adjuvant chemotherapy may improve survival in stage IV intrahepatic cholangiocarcinoma after resection, with S‐1 showing a potential survival advantage. ABSTRACT Background The survival benefit of adjuvant chemotherapy (AC) in intrahepatic cholangiocarcinoma (ICC) remains uncertain, particularly in advanced‐stage ...
Hisashi Kosaka, Masaki Ueno, Hiroji Shinkawa, Yusuke Yamamoto, Masahiko Kinoshita, Koji Komeda, Tsukasa Aihara, Satoshi Yasuda, Haruki Mori, Masaki Kaibori   +9 more
wiley   +1 more source

Transmembrane Transport of cAMP and AMP Using a Two Component Small Molecule Transport System

Angewandte Chemie, EarlyView.
Transmembrane transport of the nucleotides cAMP (cyclic adenosine monophosphate) and AMP (adenosine monophosphate) is challenging, but can be achieved using a two‐component system consisting of a synthetic anionophore (e.g., squaramides) and a lipophilic thymine derivative.
Uththara M.C. Rathnaweera, Olivia Sam, Karolis Norvaisa, Sarah R. Marshall, Randima D. De Silva Weerakonda Arachchige, Matúš Chvojka, Hennie Valkenier, Nathalie Busschaert   +7 more
wiley   +2 more sources

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma [PDF]

, 2003
BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used
A du Bois, A Villa, Alan Lamont, AN Gordon, Andrew C Hindley, B Lund, Bernard R Higgins, Christian M Kurbacher, CM Kurbacher, CM Kurbacher, DD Von Hoff, DD Von Hoff, DL Clarke-Pearson, DS Ettinger, EM Hunter, Federica Di Nicolantonio, G Blackledge, G Konecny, GJ Rustin, GJ Rustin, IA Cree, IA Cree, IA Cree, Ian A Cree, J Kaern, JS Berek, JT Thigpen, KA Donovan, Louise A Knight, M Breidenbach, M Breidenbach, M Gore, M Harries, M Markman, M Markman, M Markman, M Markman, Martin Gore, ME Gore, ME Gore, ME van der Burg, MH Neale, Michael H Neale, MJ Piccart, ML Hensley, N Myatt, OM Grecu, P Hanjani, P Therasse, Pauline A Whitehouse, PE Andreotti, PG Rose, RD Petty, Richard Osborne, Robert T. Greenlee, Sanjay Sharma, Stuart J Mercer, T Meyer, U Kurbacher CM Stier, WP McGuire   +59 more
core   +4 more sources

Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study

Annals of Gastroenterological Surgery, EarlyView.
We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors. Cases with unexpected postoperative uncovering noncurative factors had significantly poorer prognoses than those without such factors.
Hiroto Matsui, Naoki Ikenaga, Masafumi Nakamura, Takaaki Tatsuguchi, Shingo Kozono, Hirohisa Okabe, Hiromitsu Hayashi, Tomohiko Adachi, Susumu Eguchi, Kazuaki Hashimoto, Toru Hisaka, Takao Ide, Hirokazu Noshiro, Teijiro Hirashita, Atsushi Miyoshi, Atsushi Nanashima, Masatoshi Kajiwara, Tomoharu Yoshizumi, Yasuhisa Mori, Hiroaki Nagano, Kyushu Study Group of Treatment for Pancreatobilliary Cancer   +20 more
wiley   +1 more source

Synthesis of Gemcitabine-Threonine Amide Prodrug Effective on Pancreatic Cancer Cells with Improved Pharmacokinetic Properties

Molecules, 2018
To investigate the amino acid transporter-based prodrug anticancer strategy further, several amino acid-conjugated amide gemcitabine prodrugs were synthesized to target amino acid transporters in pancreatic cancer cells. The structures of the synthesized
Sungwoo Hong, Zhenghuan Fang, Hoi-Yun Jung, Jin-Ha Yoon, Soon-Sun Hong, Han-Joo Maeng   +5 more
doaj   +1 more source