Results 141 to 150 of about 160,832 (337)

Metabolic Dependencies in Pancreatic Cancer. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDA) is a highly lethal cancer with a long-term survival rate under 10%. Available cytotoxic chemotherapies have significant side effects, and only marginal therapeutic efficacy. FDA approved drugs currently used against
Brody, Jonathan R., Vaziri-Gohar, Ali, Winter, Jordan M., Zarei, Mahsa   +3 more
core   +1 more source

Phase I dose-escalation study of AZD7762, a checkpoint kinase inhibitor, in combination with gemcitabine in US patients with advanced solid tumors

, 2014
Edward A. Sausville, Patricia LoRusso, Michael A. Carducci, Judith Carter, Mary Flanagan Quinn, Lisa Malburg, Nilofer S. Azad, David Cosgrove, Richard Knight, Peter Barker, Sonya Zabludoff, Felix Agbo, Patricia Oakes, Adrian M. Senderowicz   +13 more
openalex   +1 more source

Structure–Property Associations: Breaking Paradigms for Linking Chemical Structures and Biological Properties in Drug Discovery

ChemMedChem, EarlyView.
The figure contrasts traditional structure–activity relationships, which assume direct links between chemical structures and biological activity, with structure–property associations (SPAs), which capture indirect connections across multiple biological scales.
Edgar López‐López, J. Israel Espinoza‐Castañeda, Karina Martinez‐Mayorga, José L. Medina‐Franco   +3 more
wiley   +1 more source

A multicenter phase II trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, Triapine®) and gemcitabine in advanced non-small-cell lung cancer with pharmacokinetic evaluation using peripheral blood mononuclear cells

, 2007
Brigette Ma, Boon Cher Goh, Eng Huat Tan, Kwok Chi Lam, Ross A. Soo, Swan Swan Leong, Ling Zhi Wang, Frankie Mo, Anthony T.�C. Chan, Benny Zee, Tony Mok   +10 more
openalex   +2 more sources

Patient With HIV-Associated Plasmablastic Lymphoma Responding to Bortezomib Alone and in Combination With Dexamethasone, Gemcitabine, Oxaliplatin, Cytarabine, and Pegfilgrastim Chemotherapy and Lenalidomide Alone [PDF]

, 2010
Michele Bibas, Susanna Grisetti, Lucia Alba, Giovanna Picchi, Franca Del Nonno, Andrea Antinori   +5 more
openalex   +1 more source

Association Discovery Approach in Healthcare Big Data to Identify Drug Safety and Drug Repurposing Signals

Clinical Pharmacology &Therapeutics, EarlyView.
Data science approaches have been increasingly implemented in healthcare big data to evaluate the safety and effectiveness of drugs. Association discovery is a data mining approach that finds potentially associated elements in high‐dimensional data. We present a novel implementation of the association discovery approach in longitudinal healthcare data ...
George S. Q. Tan, Lynn Miller, Sam Wade, Jenni Ilomäki, Dickson Lukose, Jia Rong, Geoffrey I. Webb   +6 more
wiley   +1 more source

Anti–Mesothelin Immunotoxin SS1P in Combination with Gemcitabine Results in Increased Activity against Mesothelin-Expressing Tumor Xenografts [PDF]

, 2007
Raffit Hassan, V. Courtney Broaddus, Shannon M. Wilson, David J. Liewehr, Jingli Zhang   +4 more
openalex   +1 more source

Cytological Features of Pancreatic Medullary Carcinoma Diagnosed by Endoscopic Ultrasound‐Guided Fine Needle Aspiration

Diagnostic Cytopathology, EarlyView.
ABSTRACT Pancreatic medullary carcinoma is an extremely rare tumor classified as a histological subtype of pancreatic ductal adenocarcinoma. We report a case of a pancreatic medullary carcinoma and describe its cytological features. A 75‐year‐old woman presented with lower back pain, epigastric discomfort, and a tumor‐like lesion in the pancreatic body.
Urara Okawa, Keishi Mizuguchi, Miyu Okuda, Tatsuya Mori, Hiroko Ikeda   +4 more
wiley   +1 more source

Gemcitabine and chlorotoxin conjugated iron oxide nanoparticles for glioblastoma therapy

, 2015
Qingxin Mu, Guanyou Lin, Victoria K. Patton, Kui Wang, Oliver W. Press, Miqin Zhang   +5 more
openalex   +2 more sources

Liposomal irinotecan in gemcitabine-refractory metastatic pancreatic cancer: efficacy, safety and place in therapy [PDF]

, 2017
Emma Kipps, Kate Young, Naureen Starling
openalex   +1 more source