Gene-environment interaction in the pathophysiology of type 1 diabetes [PDF]
Frontiers in EndocrinologyType 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities.
Rahul Mittal +4 more
doaj +3 more sources
Gene-environment interaction in molar-incisor hypomineralization.
PLoS ONE, 2021 Molar incisor hypomineralization (MIH) is an enamel condition characterized by lesions ranging in color from white to brown which present rapid caries progression, and mainly affects permanent first molars and incisors. These enamel defects usually occur
Mariana Bezamat +22 more
doaj +2 more sources
Gene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological Systems [PDF]
Frontiers in Psychiatry, 2015 Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple and partially overlapping sets of susceptibility genes interact each other and with the environment, predisposing individuals to the development of the illness ...
N. Lopizzo +7 more
semanticscholar +7 more sources
Gene-environment interaction in functional hypothalamic amenorrhea [PDF]
Frontiers in EndocrinologyFunctional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea and chronic anovulation in adolescent girls and young women, diagnosed after excluding other organic causes.
Federica Barbagallo +11 more
doaj +2 more sources
Efficient gene–environment interaction testing through bootstrap aggregating [PDF]
Scientific Reports, 2023 Gene–environment (GxE) interactions are an important and sophisticated component in the manifestation of complex phenotypes. Simple univariate tests lack statistical power due to the need for multiple testing adjustment and not incorporating potential ...
Michael Lau +3 more
doaj +2 more sources
Interactive effects between lead-cadmium co-exposure and VEGFA gene polymorphisms on renal dysfunction: a gene–environment interaction study [PDF]
Frontiers in Public HealthBackgroundLead (Pb) and cadmium (Cd) are common persistent environmental pollutants, may cause renal dysfunction following long-term exposure. This study investigated whether vascular endothelial growth factor a (VEGFA) gene polymorphisms modify the ...
Yaotang Deng +11 more
doaj +2 more sources
PLoS Genetics, 2016 How combinations of gene-environment interactions collectively give rise to genotype-environment interactions is not fully understood. To shed light on this problem, we genetically dissected an environment-specific poor growth phenotype in a cross of two
Takeshi Matsui, Ian M Ehrenreich
doaj +2 more sources
Gene-environment interaction and maternal arsenic methylation efficiency during pregnancy
Environment International, 2019 Background: Single nucleotide polymorphisms (SNPs) may influence arsenic methylation efficiency, affecting arsenic metabolism. Whether gene-environment interactions affect arsenic metabolism during pregnancy remains unclear, which may have implications ...
Shangzhi Gao +9 more
doaj +2 more sources
Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction [PDF]
BMC PsychologyMathematical ability is influenced by genes and environment. This study focused on the effect of DRD2, a candidate gene for working memory, on mathematical ability.
Qing Yang +4 more
doaj +2 more sources
Inference of gene-environment interaction from heterogeneous case-parent trios [PDF]
Frontiers in Genetics, 2023 Introduction: In genetic epidemiology, log-linear models of population risk may be used to study the effect of genotypes and exposures on the relative risk of a disease.
Pulindu Ratnasekera +2 more
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