Genetic interactions affecting human gene expression identified by variance association mapping
eLife, 2014 Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown +9 more
doaj +1 more source
Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits
BMC Genomics, 2009 Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song +4 more
doaj +1 more source
Metabolic syndrome, diabetes and atherosclerosis: Influence of gene-environment interaction [PDF]
, 2009 Despite remarkable progress in diagnosis and understanding of risk factors, cardiovascular disease (CVD) remains still the leading cause of morbidity and mortality in the world\u27s developed countries.
Andreassi, Maria Grazia
core +1 more source
The lipoprotein lipase S447X polymorphism and plasma lipids
Journal of Lipid Research, 2004 We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee +6 more
doaj +1 more source
The Genetic Architecture of Noise-Induced Hearing Loss: Evidence for a Gene-by-Environment Interaction. [PDF]
, 2016 The discovery of environmentally specific genetic effects is crucial to the understanding of complex traits, such as susceptibility to noise-induced hearing loss (NIHL).
Allayee, Hooman +10 more
core +3 more sources
Breast Cancer Research, 2023 Background Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among ...
Kristin L. Young +8 more
doaj +1 more source
Replication of Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population [PDF]
Journal of Preventive Medicine and Public Health, 2016 Objectives Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity.
Hyun-Jin Kim +2 more
doaj +1 more source
Differential expression of placental glucocorticoid receptors and growth arrest-specific transcript 5 in term and preterm pregnancies: evidence for involvement of maternal stress. [PDF]
, 2014 This article has been made available through the Brunel Open Access Publishing Fund.Pregnancy-specific stress predicts birth outcomes. We hypothesized that there is a maternal stress-GR interaction that can influence fetal birth weight.
Gidron, Y +6 more
core +3 more sources
Gene-environment interaction: A genetic-epidemiological approach [PDF]
Journal of Medical Biochemistry, 2010 Classical epidemiology addresses the distribution and determinants of diseases in populations, and the factors associated with disease causation, with the aim of preventing disease. Both genetic and environmental factors may contribute to susceptibility,
Pekmezović Tatjana
doaj
Inference of gene-environment interaction from heterogeneous case-parent trios
Frontiers in Genetics, 2023 Introduction: In genetic epidemiology, log-linear models of population risk may be used to study the effect of genotypes and exposures on the relative risk of a disease.
Pulindu Ratnasekera +2 more
doaj +1 more source