Results 1 to 10 of about 1,152,572 (252)

Gene-environment interaction in functional hypothalamic amenorrhea. [PDF]

Front Endocrinol (Lausanne)
Functional hypothalamic amenorrhea (FHA) is a common cause of amenorrhea and chronic anovulation in adolescent girls and young women, diagnosed after excluding other organic causes.
Barbagallo F, Bosoni D, Perone V, Cucinella L, Dealberti D, Cannarella R, Calogero AE, Nappi RE.   +7 more
europepmc   +2 more sources

Efficient gene-environment interaction testing through bootstrap aggregating. [PDF]

Sci Rep, 2023
Gene–environment (GxE) interactions are an important and sophisticated component in the manifestation of complex phenotypes. Simple univariate tests lack statistical power due to the need for multiple testing adjustment and not incorporating potential ...
Lau M, Kress S, Schikowski T, Schwender H.   +3 more
europepmc   +2 more sources

Interactive effects between lead-cadmium co-exposure and VEGFA gene polymorphisms on renal dysfunction: a gene-environment interaction study. [PDF]

Front Public Health
BackgroundLead (Pb) and cadmium (Cd) are common persistent environmental pollutants, may cause renal dysfunction following long-term exposure. This study investigated whether vascular endothelial growth factor a (VEGFA) gene polymorphisms modify the ...
Deng Y, Wen Y, Duan W, Zhao Z, Li G, Zhou J, Yang L, Yang J, Sun Y, Qiu M, Liu L.   +10 more
europepmc   +2 more sources

Exploring the influence of the DRD2 gene on mathematical ability: perspectives of gene association and gene-environment interaction. [PDF]

BMC Psychol
Mathematical ability is influenced by genes and environment. This study focused on the effect of DRD2, a candidate gene for working memory, on mathematical ability.
Yang Q, Zhang X, Zhang L, Cheng C, Zhao J.   +4 more
europepmc   +2 more sources

Gene-environment interaction in the pathophysiology of type 1 diabetes. [PDF]

Front Endocrinol (Lausanne)
Type 1 diabetes (T1D) is a complex metabolic autoimmune disorder that affects millions of individuals worldwide and often leads to significant comorbidities.
Mittal R, Camick N, Lemos JRN, Hirani K.
europepmc   +2 more sources

Gene-environment interaction analysis of school quality and educational inequality. [PDF]

NPJ Sci Learn
We study to what extent schools increase or decrease environmental and genetic influences on educational performance. Building on behavioral genetics literature on gene-environment interactions and sociological literature on the compensating and ...
Stienstra K, Knigge A, Maas I.
europepmc   +2 more sources

Bivariate genetic modelling of the response to an oral glucose tolerance challenge: A gene x environment interaction approach [PDF]

, 2009
AIMS/HYPOTHESIS: Twin and family studies have shown the importance of genetic factors influencing fasting and 2 h glucose and insulin levels. However, the genetics of the physiological response to a glucose load has not been thoroughly investigated ...
AJ Hanley, B Benyamin, D Lann, E Zeggini, EJ Geus De, EJ Mayer, G. F. Liu, H Snieder, H Snieder, H Snieder, H. Riese, H. Snieder, J Baird, JM McCaffery, K Schousboe, L Gaal Van, M Lehtovirta, M Lehtovirta, M. Mangino, MCBS Neale, MCCL Neale, NJ Samani, NY Souren, P Poulsen, P Poulsen, Q Qiao, R. P. Stolk, S Katoh, S. D. O’Dell, SM Haffner, T Andrew, T. D. Spector, TD Gould, TD Spector, The DECODE Study Group, TM Frayling, World Health Organization   +36 more
core   +15 more sources

Gene–Environment Interactions in Severe Mental Illness [PDF]

Frontiers in Psychiatry, 2014
Severe mental illness (SMI) is a broad category that includes schizophrenia, bipolar disorder, and severe depression. Both genetic disposition and environmental exposures play important roles in the development of SMI. Multiple lines of evidence suggest that the roles of genetic and environmental factors depend on each other.
Rudolf eUher, Rudolf eUher
openaire   +3 more sources

Mito-SiPE is a sequence-independent and PCR-free mtDNA enrichment method for accurate ultra-deep mitochondrial sequencing

Communications Biology, 2022
Mito-SiPE is a mitochondrial DNA (mtDNA) enrichment method that can derive high-quality mtDNA for rare heteroplasmy analysis, without relying on PCR or probes.
Darren J. Walsh, David J. Bernard, Faith Pangilinan, Madison Esposito, Denise Harold, Anne Parle-McDermott, Lawrence C. Brody   +6 more
doaj   +1 more source

Gene–Environment Interaction in Major Depression: Focus on Experience-Dependent Biological Systems [PDF]

Frontiers in Psychiatry, 2015
Major depressive disorder (MDD) is a multifactorial and polygenic disorder, where multiple and partially overlapping sets of susceptibility genes interact each other and with the environment, predisposing individuals to the development of the illness. Thus, MDD results from a complex interplay of vulnerability genes and environmental factors that act ...
Nicola eLopizzo, Luisella eBocchio Chiavetto, Nadia eCattaneo, Giona ePlazzotta, Frank eTarazi, Carmine M Pariante, Marco A. Riva, Annamaria eCattaneo, Annamaria eCattaneo   +8 more
openaire   +6 more sources