Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]
, 2013 The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani +58 more
core +13 more sources
How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Frontiers in Plant Science, 2023 Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
doaj +1 more source
Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis
Journal of Physiological Anthropology, 2023 Background Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development.
Tian Xia, Kazuhiro Nakayama
doaj +1 more source
Bayesian semiparametric analysis for two-phase studies of gene-environment interaction [PDF]
, 2013 The two-phase sampling design is a cost-efficient way of collecting expensive covariate information on a judiciously selected subsample. It is natural to apply such a strategy for collecting genetic data in a subsample enriched for exposure to ...
Ahn, Jaeil +3 more
core +1 more source
BMC Bioinformatics, 2012 Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele +4 more
doaj +1 more source
Gene–environment interactions in human health: case studies and strategies for developing new paradigms and research methodologies [PDF]
Frontiers in Genetics, 2014 THE SYNERGISTIC EFFECTS OF GENES AND THE ENVIRONMENT ON HEALTH ARE EXPLORED IN THREE CASE STUDIES: adult lactase persistence, autism spectrum disorders, and the metabolic syndrome, providing examples of the interactive complexities underlying these phenotypes.
openaire +3 more sources
The impact of imprecisely measured covariates on estimating gene-environment interactions [PDF]
, 2006 BACKGROUND The effects of measurement error in epidemiological exposures and confounders on estimated effects of exposure are well described, but the effects on estimates for gene-environment interactions has received rather less attention.
Cade, J.E. +2 more
core +2 more sources
A flexible Bayesian model for studying gene-environment interaction. [PDF]
PLoS Genetics, 2012 An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence ...
Kai Yu +6 more
doaj +1 more source
Assessing Orthogonality in Gene-Environment Interaction Studies Using Polygenic Indices. [PDF]
Behav GenetSlob EAW, Muslimova D, Rietveld CA.
europepmc +3 more sources
Associations of Romantic Partners' Characteristics with Alcohol Consumption and Binge Drinking: Examining Evidence for Gene-Environment Interaction. [PDF]
Clin Psychol SciStephenson M +10 more
europepmc +3 more sources