Results 21 to 30 of about 6,560,367 (336)
Nature Communications, 2020 The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to continuous traits taking into account all ...
Jonathan Sulc +8 more
semanticscholar +1 more source
Journal of Psychiatry and Neuroscience, 2020 Phenotypic heterogeneity and complicated gene–environment interplay in etiology are among the primary factors that hinder the identification of genetic variants associated with cocaine use disorder.To detect novel genetic variants associated with cocaine use disorder, we derived disease traits with reduced phenotypic heterogeneity using cluster ...
Sun, Jiangwen +3 more
openaire +4 more sources
How ambient temperature affects the heading date of foxtail millet (Setaria italica)
Frontiers in Plant Science, 2023 Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang +8 more
doaj +1 more source
Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis
Journal of Physiological Anthropology, 2023 Background Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development.
Tian Xia, Kazuhiro Nakayama
doaj +1 more source
Bayesian semiparametric analysis for two-phase studies of gene-environment interaction [PDF]
, 2013 The two-phase sampling design is a cost-efficient way of collecting expensive covariate information on a judiciously selected subsample. It is natural to apply such a strategy for collecting genetic data in a subsample enriched for exposure to ...
Ahn, Jaeil +3 more
core +1 more source
BMC Bioinformatics, 2012 Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele +4 more
doaj +1 more source
Gene–Environment Interactions at Nucleotide Resolution
PLoS Genetics, 2010 Interactions among genes and the environment are a common source of phenotypic variation. To characterize the interplay between genetics and the environment at single nucleotide resolution, we quantified the genetic and environmental interactions of four quantitative trait nucleotides (QTN) that govern yeast sporulation efficiency. We first constructed
Gerke, Justin +3 more
openaire +6 more sources
A flexible Bayesian model for studying gene-environment interaction. [PDF]
PLoS Genetics, 2012 An important follow-up step after genetic markers are found to be associated with a disease outcome is a more detailed analysis investigating how the implicated gene or chromosomal region and an established environment risk factor interact to influence ...
Kai Yu +6 more
doaj +1 more source
Regulation of Pancreatic β-Cell Mass by Gene-Environment Interaction [PDF]
Diabetes & Metabolism Journal, 2022 The main pathogenic mechanism of diabetes consists of an increase in insulin resistance and a decrease in insulin secretion from pancreatic β-cells. The number of diabetic patients has been increasing dramatically worldwide, especially in Asian people ...
Shun-ichiro Asahara +2 more
doaj +1 more source
Alcohol consumption and lifetime change in cognitive ability:a gene × environment interaction study [PDF]
, 2014 Studies of the effect of alcohol consumption on cognitive ability are often confounded. One approach to avoid confounding is the Mendelian randomization design.
AJ Birley +39 more
core +1 more source