Results 21 to 30 of about 6,713,185 (334)

Association of genetic variation with cirrhosis: a multi-trait genome-wide association and gene-environment interaction study.

Gastroenterology, 2020
BACKGROUND In contrast to most other common diseases, few genetic variants have been identified that impact risk of cirrhosis. We aimed to identify new genetic variants that predispose to cirrhosis, to test whether such variants, aggregated into a ...
C. Emdin, Mary E. Haas, Veeral H. Ajmera, Tracey G. Simon, J. Homburger, C. Neben, Lan Jiang, Wei-Qi Wei, Q. Feng, A. Zhou, J. Denny, K. Corey, R. Loomba, S. Kathiresan, A. Khera   +14 more
semanticscholar   +1 more source

Quantification of the overall contribution of gene-environment interaction for obesity-related traits

Nature Communications, 2020
The growing sample size of genome-wide association studies has facilitated the discovery of gene-environment interactions (GxE). Here we propose a maximum likelihood method to estimate the contribution of GxE to continuous traits taking into account all ...
Jonathan Sulc, N. Mounier, F. Günther, T. Winkler, A. Wood, T. Frayling, I. Heid, M. Robinson, Z. Kutalik   +8 more
semanticscholar   +1 more source

A genome-wide association study of cocaine use disorder accounting for phenotypic heterogeneity and gene–environment interaction

Journal of Psychiatry and Neuroscience, 2020
Phenotypic heterogeneity and complicated gene–environment interplay in etiology are among the primary factors that hinder the identification of genetic variants associated with cocaine use disorder.To detect novel genetic variants associated with cocaine use disorder, we derived disease traits with reduced phenotypic heterogeneity using cluster ...
Sun, Jiangwen, Kranzler, Henry R., Gelernter, Joel, Bi, Jinbo   +3 more
openaire   +4 more sources

How ambient temperature affects the heading date of foxtail millet (Setaria italica)

Frontiers in Plant Science, 2023
Foxtail millet (Setaria italica), a short-day plant, is one of the important crops for food security encountering climate change, particularly in regions where it is a staple food.
Ya-Chen Huang, Yu-tang Wang, Yee-ching Choong, Hsin-ya Huang, Yu-ru Chen, Tzung-Fu Hsieh, Tzung-Fu Hsieh, Yann-rong Lin, Yann-rong Lin   +8 more
doaj   +1 more source

Signatures of adaptation in myopia-related genes on the sunlight exposure hypothesis

Journal of Physiological Anthropology, 2023
Background Myopia is a common eye disorder that results from gene-environment interactions. The prevalence of myopia varies across populations, and exposure to bright sunlight may prevent its development.
Tian Xia, Kazuhiro Nakayama
doaj   +1 more source

Effects of Thyroxine Exposure on Osteogenesis in Mouse Calvarial Pre-Osteoblasts [PDF]

, 2013
The incidence of craniosynostosis is one in every 1,800-2500 births. The gene-environment model proposes that if a genetic predisposition is coupled with environmental exposures, the effects can be multiplicative resulting in severely abnormal phenotypes.
A Mansukhani, AK Coussens, BD Stamper, BK Huang, BU Ang, C Owen, C Yao, CB Harvey, CH Shackleton, CW Li, D Gomez, D Johnson, DC Robinson, DP Rice, DT Gault, G Radetti, G Ramajayam, GA Brent, GM Morriss-Kay, GR Williams, H Kohara, H Miraoui, HJ Kim, J Connerney, J Esparza, J Zumbrunn, JA Greenwald, Jack C. Yu, James J. Cray, JH Bassett, JH Oh, JL Penfold, JM Britto, JQ Feng, JS Morey, K Kasono, KA Kapp-Simon, Kameron Khaksarfard, KM Lee, M Bodo, M Menking, M Segni, MH Sheng, MM Cohen Jr, Mohammed Elsalanty, PJ Marie, R Rice, S Akita, S Wadhwa, S Weiss, SA Boyadjiev, SA Rasmussen, Seth M. Weinberg, W Arlt, W Riggs Jr, WM Chadduck, Xing-Ming Shi, Y Xiong, Z von Marschall   +58 more
core   +10 more sources

Bayesian semiparametric analysis for two-phase studies of gene-environment interaction [PDF]

, 2013
The two-phase sampling design is a cost-efficient way of collecting expensive covariate information on a judiciously selected subsample. It is natural to apply such a strategy for collecting genetic data in a subsample enriched for exposure to ...
Ahn, Jaeil, Ghosh, Malay, Gruber, Stephen B., Mukherjee, Bhramar   +3 more
core   +1 more source

Simulating gene-gene and gene-environment interactions in complex diseases: Gene-Environment iNteraction Simulator 2

BMC Bioinformatics, 2012
Background The analysis of complex diseases is an important problem in human genetics. Because multifactoriality is expected to play a pivotal role, many studies are currently focused on collecting information on the genetic and environmental factors ...
Pinelli Michele, Scala Giovanni, Amato Roberto, Cocozza Sergio, Miele Gennaro   +4 more
doaj   +1 more source

Gene–Environment Interactions at Nucleotide Resolution

PLoS Genetics, 2010
Interactions among genes and the environment are a common source of phenotypic variation. To characterize the interplay between genetics and the environment at single nucleotide resolution, we quantified the genetic and environmental interactions of four quantitative trait nucleotides (QTN) that govern yeast sporulation efficiency. We first constructed
Gerke, Justin, Lorenz, Kim, Ramnarine, Shelina, Cohen, Barak   +3 more
openaire   +6 more sources

The impact of imprecisely measured covariates on estimating gene-environment interactions [PDF]

, 2006
BACKGROUND The effects of measurement error in epidemiological exposures and confounders on estimated effects of exposure are well described, but the effects on estimates for gene-environment interactions has received rather less attention.
Cade, J.E., Gilthorpe, M.S., Greenwood, D.C.   +2 more
core   +2 more sources