Results 31 to 40 of about 1,093,414 (290)

Discovering gene–environment interactions in Glioblastoma through a comprehensive data integration bioinformatics method

NeuroToxicology, 2013
Glioblastoma multiforme (GBM) is the most common and aggressive type of human brain tumor. Although considerable efforts to delineate the underlying pathophysiological pathways have been made during the last decades, only very limited progress on treatment have been achieved because molecular pathways that drive the aggressive nature of GBM are largely
Department of Environmental and Occupational Health, Florida International University, Miami, FL 33199, United States ( host institution ), Kunkle, Brian ( author ), Yoo, Changwon ( author ), Roy, Deodutta ( author )   +3 more
openaire   +3 more sources

Metabolic syndrome, diabetes and atherosclerosis: Influence of gene-environment interaction [PDF]

, 2009
Despite remarkable progress in diagnosis and understanding of risk factors, cardiovascular disease (CVD) remains still the leading cause of morbidity and mortality in the world\u27s developed countries.
Andreassi, Maria Grazia
core   +1 more source

Candidate gene-environment interactions in substance abuse: A systematic review.

PLoS ONE, 2023
BackgroundThe abuse of psychogenic drugs can lead to multiple health-related problems. Genetic and environmental vulnerabilities are factors in the emergence of substance use disorders.
Zheng Jiang, Zidong Chen, Xi Chen
doaj   +1 more source

Alcohol consumption and lifetime change in cognitive ability:a gene × environment interaction study [PDF]

, 2014
Studies of the effect of alcohol consumption on cognitive ability are often confounded. One approach to avoid confounding is the Mendelian randomization design.
AJ Birley, David C. Liewald, EJ Neafsey, F Panza, F Zanjani, G Davey Smith, Gail Davies, Geraldine McNeill, HK Seitz, Ian J. Deary, IHM Friesema, IJ Deary, IJ Deary, IJ Deary, J Corley, Janie Corley, John M. Starr, JW Kim, KJ Anstey, LF Masson, LM Hines, LM Houlihan, M Grønbæk, M Richards, M Zgombic-Knight, MA Collins, MF Folstein, Office of Population Censuses and Surveys, Office of Population Censuses and Surveys, P Brennan, PA Dickson, PL Brennan, S Ebrahim, S Sabia, Scottish Council for Research in Education, SJ Lewis, SL Au Yeung, Stuart J. Ritchie, Timothy C. Bates, Y Li   +39 more
core   +1 more source

Artificial neural networks modeling gene-environment interaction

BMC Genetics, 2012
Background Gene-environment interactions play an important role in the etiological pathway of complex diseases. An appropriate statistical method for handling a wide variety of complex situations involving interactions between variables is still lacking,
Günther Frauke, Pigeot Iris, Bammann Karin   +2 more
doaj   +1 more source

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium

Breast Cancer Research, 2023
Background Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among ...
Kristin L. Young, Andrew F. Olshan, Kathryn Lunetta, Mariaelisa Graff, Lindsay A. Williams, Song Yao, Gary R. Zirpoli, Melissa Troester, Julie R. Palmer   +8 more
doaj   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2009
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
A Carvajal-Rodriguez, B Peng, C Li, Consortium TWTCC, D Gasbarra, Daniel D'Andrea, DE Weeks, DJ Hunter, DW Hosmer, Gennaro Miele, Giancarlo Raiconi, Group TGCR, J Haldane, J Hoh, J Ott, JD Terwilliger, KE Lohmueller, LM Ploughman, LW Hahn, M Boehnke, M Garcia-Closas, M Schmidt, Mario Nicodemi, MD Ritchie, Michele Pinelli, MJ Khoury, NM Laird, Roberto Amato, Sergio Cocozza, SM Leal, WJ Gauderman, Y Murase   +31 more
core   +6 more sources