Results 41 to 50 of about 6,713,185 (334)

A Gene–Environment Interaction Between Smoking and Gene polymorphisms Provides a High Risk of Two Subgroups of Sarcoidosis

Scientific Reports, 2019
The influence and effect of cigarette smoking in sarcoidosis is unclear. Here, we evaluated gene-environment interaction between multiple genetic variants including HLA genes and smoking in sarcoidosis defined by two clinical phenotypes, Löfgren’s ...
Natalia V. Rivera, K. Patasova, S. Kullberg, L. Diaz-Gallo, T. Iseda, C. Bengtsson, L. Alfredsson, A. Eklund, I. Kockum, J. Grunewald, L. Padyukov   +10 more
semanticscholar   +1 more source

Metabolic syndrome, diabetes and atherosclerosis: Influence of gene-environment interaction [PDF]

, 2009
Despite remarkable progress in diagnosis and understanding of risk factors, cardiovascular disease (CVD) remains still the leading cause of morbidity and mortality in the world\u27s developed countries.
Andreassi, Maria Grazia
core   +1 more source

Artificial neural networks modeling gene-environment interaction

BMC Genetics, 2012
Background Gene-environment interactions play an important role in the etiological pathway of complex diseases. An appropriate statistical method for handling a wide variety of complex situations involving interactions between variables is still lacking,
Günther Frauke, Pigeot Iris, Bammann Karin   +2 more
doaj   +1 more source

Genetic interactions affecting human gene expression identified by variance association mapping

eLife, 2014
Non-additive interaction between genetic variants, or epistasis, is a possible explanation for the gap between heritability of complex traits and the variation explained by identified genetic loci.
Andrew Anand Brown, Alfonso Buil, Ana Viñuela, Tuuli Lappalainen, Hou-Feng Zheng, J Brent Richards, Kerrin S Small, Timothy D Spector, Emmanouil T Dermitzakis, Richard Durbin   +9 more
doaj   +1 more source

Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits

BMC Genomics, 2009
Background The purpose of this research was to develop a novel information theoretic method and an efficient algorithm for analyzing the gene-gene (GGI) and gene-environmental interactions (GEI) associated with quantitative traits (QT).
Liu Song, Sucheston Lara, Chanda Pritam, Zhang Aidong, Ramanathan Murali   +4 more
doaj   +1 more source

Gene-environment interaction study for BMI reveals interactions between genetic factors and physical activity, alcohol consumption and socioeconomic status

PLoS Genetics, 2017
Previous genome-wide association studies (GWAS) have identified hundreds of genetic loci to be associated with body mass index (BMI) and risk of obesity.
M. Rask-Andersen, T. Karlsson, W. Ek, Å. Johansson   +3 more
semanticscholar   +1 more source

The lipoprotein lipase S447X polymorphism and plasma lipids

Journal of Lipid Research, 2004
We studied 4,058 subjects from a representative sample of the Singapore population 1) to determine the association between the S447X polymorphism at the LPL locus and serum lipid concentration in Chinese, Malays, and Asian Indians living in Singapore and
J. Lee, C.S. Tan, K.S. Chia, C.E. Tan, S.K. Chew, J.M. Ordovas, E.S. Tai   +6 more
doaj   +1 more source

Influence of alcohol consumption and alcohol metabolism variants on breast cancer risk among Black women: results from the AMBER consortium

Breast Cancer Research, 2023
Background Moderate to heavy alcohol consumption is associated with an increased risk of breast cancer. The etiologic role of genetic variation in genes involved in ethanol metabolism has not been established, with little information available among ...
Kristin L. Young, Andrew F. Olshan, Kathryn Lunetta, Mariaelisa Graff, Lindsay A. Williams, Song Yao, Gary R. Zirpoli, Melissa Troester, Julie R. Palmer   +8 more
doaj   +1 more source

A novel approach to simulate gene-environment interactions in complex diseases [PDF]

, 2009
Background: Complex diseases are multifactorial traits caused by both genetic and environmental factors. They represent the major part of human diseases and include those with largest prevalence and mortality (cancer, heart disease, obesity, etc ...
A Carvajal-Rodriguez, B Peng, C Li, Consortium TWTCC, D Gasbarra, Daniel D'Andrea, DE Weeks, DJ Hunter, DW Hosmer, Gennaro Miele, Giancarlo Raiconi, Group TGCR, J Haldane, J Hoh, J Ott, JD Terwilliger, KE Lohmueller, LM Ploughman, LW Hahn, M Boehnke, M Garcia-Closas, M Schmidt, Mario Nicodemi, MD Ritchie, Michele Pinelli, MJ Khoury, NM Laird, Roberto Amato, Sergio Cocozza, SM Leal, WJ Gauderman, Y Murase   +31 more
core   +6 more sources

Replication of Gene-by-psychosocial Stress Interaction Effects on Central Adiposity in a Korean Population [PDF]

Journal of Preventive Medicine and Public Health, 2016
Objectives Central obesity plays a major role in the development of many chronic diseases, including cardiovascular disease and cancer. Chronic stress may be involved in the pathophysiology of central obesity.
Hyun-Jin Kim, Jin-Young Min, Kyoung-Bok Min   +2 more
doaj   +1 more source