Results 71 to 80 of about 1,076,570 (292)

Exploiting Gene-Environment Independence for Analysis of Case-Control Studies: An Empirical Bayes Approach to Trade Off between Bias and Efficiency [PDF]

open access: yes, 2006
Standard prospective logistic regression analysis of case-control data often leads to very imprecise estimates of gene-environment interactions due to small numbers of cases or controls in cells of crossing genotype and exposure.
Chatterjee, Nilanjan, Mukherjee, Bhramar
core   +4 more sources

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

Dopamine transporter and transmission of psychopathological risk. A review of gene-environment interplay [PDF]

open access: yes, 2017
Research underlines that intergenerational transmission of psychopathological risk results from a complex interplay of genetic and environmental risk factors which predispose child to develop emotionalbehavioral problems. Mechanisms of transmission are
Ballarotto, Giulia   +5 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Gene-environment interaction effects on lung function- a genome-wide association study within the Framingham heart study [PDF]

open access: yes, 2013
Background: Previous studies in occupational exposure and lung function have focused only on the main effect of occupational exposure or genetics on lung function.
Christiani, David C   +2 more
core   +2 more sources

Social Integration and Sleep Disturbance: A Gene-Environment Interaction Study

open access: yesCollabra, 2016
Objective: Low levels of perceived social integration, or loneliness, are associated with increased risk for a range of poor health outcomes. Sleep disturbance plays a central role in the evolutionary theory of loneliness, which provides a mechanistic ...
David A. Sbarra
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Expanding the modern synthesis II: Formal perspectives on the inherent role of niche construction in fitness [PDF]

open access: yes, 2010
Expanding the modern synthesis requires elevating the role of interaction within and across various biological scales to the status of an evolutionary principle.
Rodrick Wallace
core   +1 more source

The Role of Genes in Defining a Molecular Biology of PTSD [PDF]

open access: yes, 2014
Because environmental exposure to trauma is the sine qua non for the development of Post Traumatic Stress Disorder (PTSD), the recent focus on genetic studies has been noteworthy. The main catalyst for such studies is the observation from epidemiological
Flory, Janine D.   +3 more
core   +1 more source

The intracellular domain of TLR2 is capable of high‐affinity Zn binding: possible outcomes for the receptor activation

open access: yesFEBS Letters, EarlyView.
Toll‐like receptors (TLRs) are important in the innate immune system. This study explores the zinc‐binding ability of the TLR2 TIR domain (TLR2TIR). We found that TLR2TIR binds zinc with nanomolar affinity through its cysteine residues. Two of them, C673 and C713, are vital for receptor activation, indicating that zinc may play a role in initiating ...
Vladislav A. Lushpa   +8 more
wiley   +1 more source

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