Commentary: Facing the Challenge of Gene-Environment Interaction: The Two-by-Four Table and Beyond [PDF]
, 2001 Lorenzo D. Botto, Muin J. Khoury
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Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Gene-environment interaction and personality/behaviour
Annals of General Psychiatry, 2006 Göktürk Camilla +9 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
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Venous Thrombosis — The Interaction of Genes and Environment
, 1998 R.M. Bertina, Frits R. Rosendaal
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Gene-environment interaction between an aldehyde dehydrogenais-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer [PDF]
, 2001 openalex +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
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Re-analysis and meta-analysis of summary statistics from gene-environment interaction studies. [PDF]
Bioinformatics, 2023 Pham DT +14 more
europepmc +1 more source
Different data from different labs: Lessons from studies of gene–environment interaction [PDF]
, 2002 Douglas Wahłsten +19 more
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EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
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